Participating Labs

Dr. Ayman Al Habeeb - - TGH
Significant overexpression of the Merkel cell polyomavirus (MCPyV) large T antigen in Merkel cell carcinoma.

Dr. Anne Agur - - MSB
Current research involves the development of a 3D system for static and dynamic modelling of human skeletal muscle. My interest is in the functional consequences of structural changes to skeletal muscle (e.g. due to neuromuscular diseases and injuries).

Dr. B. Alman - - HSC
Our laboratory studies the molecular mechanisms responsible for the deregulation of cellular growth control in agressive fibromatosis (desmoid tumour) and cartilage neoplasms (e.g. chondrosarcomas). We identified development signalling pathways that are inappropriately activated in both types of lesions. Our current work focuses on determining somatic mutilations that may be responsible for the activation, identifying novel mediators in the signalling pathways, and determining if a pharmacologic approach can be used to modulate the pathway activation. The long-term goal of this work is to develop novel pharmacologic therapies for these otherwise difficult to treat lesions. Some of the information learned from our work on tumours can be applied to repair processes and bone growth. We are currently working to determine how these signalling pathways regulate normal bone growth and wound healing.

Dr. Susanne Benseler - - HSC
We are exploring how to rapidly recognize and control inflammation in the blood vessels and surrounding tissue in the brains of children. This disease is called central nervous system (CNS) vasculitis. Previously healthy children present to our hospital with a wide range of serious symptoms, such as seizures or strokes. We then realized that the underlying cause of these symptoms is inflammation of the brain vessels.

Dr. Rod Bremner - - TWRI
Our focus is cancer research. First, we study the role of the retinoblastoma protein (Rb) in neurogenesis and the childhood eye cancer retinoblastoma. Rb is a tumor suppressor that is part of a pathway defective in most, if not all, human cancers.

Dr. Patricia Brubaker - - MSB
The lab specializes in certain intestinal hormones and their roles in the treatment of patients with type 2 diabetes and intestinal insufficiency.

Dr. Mac Burnham - - MSB
At present, we do not know why seizures occur, how they affect the brain, or how anticonvulsant drugs suppress them. My laboratory is working on these problems, using a variety of animal models and biochemical assays. Current projects include: 1) a study of how seizures enhance neurogenesis, gliosis and cell death; 2) a molecular biology study of the long-term effects of seizures on gene expression ; 3) a study of the anticonvulsant effects of progesterone-like compounds; 4) a study of the behavioral effects of seizures; and 5) a study of the mechanism of action of the ketogenic diet.

Dr. Peter Carlen - - HSC
Mechanisms of neural synchrony and entrainment (epilepsy), and neurodegenerative processes.

Dr. Miguel Cortez - - HSC
The lab studies EEG and VEEG monitoring of refractory models of epilepsies and atypical absence seizures derived from developmental cholesterol synthesis inhibition.

Dr. Peter Dirks - - HSC
My clinical interests lie with the entire spectrum of paediatric neurosurgical practice, with emphasis on the surgical treatment of childhood brain tumours and brain vascular malformations, brain tumours, cancer stem cells, neural stem cells and neural development.

Dr. Daniel Dumont - - SHSC
Our research has the potential to impact numerous diseases where aberrant vessel growth or vessel stability lead to progression of disease or increased complications, such as diabetes, heart disease and cancer. Furthermore, our group is also using this knowledge to in fact also augment vessel growth for applications in regenerative medicine.

Dr. M. Fehlings - - TWRI
Neurotrauma research using molecular, neuroanatomical and electrophysiological approaches; Spinal cord repair and regeneration using stem cells and tissue engineering techniques.

Dr. Steven Gallinger - - MSH
Gastrointestinal Canger Cenetics.

Dr. Adria Giacca - - MSB
The primary theme of Dr. Giacca's research is the investigation of the effects of excess circulating energy substrates, in particular free fatty acids, on insulin action, secretion and kinetics, and the implication of these effects for the pathogenesis of diabetes. Secondary themes of research are the studies of the effects of nutrient and insulin excess on: i) the proliferation of normal and tumorous colonic epithelial cells; ii) atherosclerosis and restenosis in animal models.

Dr. Michael Glogauer - - FG
My lab studies neutrophil function and oral innate immunity. Projects in the lab include osteoclast biology with a focus on bisphosphonate mediated jaw osteonecrosis, development of non-invasive diagnostic tests for periodontal diseases and development of non-invasive diagnostic tests for innate immune function.

Dr. Teodor Grantcharovt - - SMH
My research focuses on development, validation and implementation in practice of novel methods for training and assessment of surgical skills. The surgical skills lab at St. Michael's Hospital includes state-of-the-art virtual reality computer simulators and box-trainer modules for basic and advanced laparoscopic procedures. Our current activities aim at investigating the impact of evidence-based training curriculum on the quality and speed of skills acquisition in minimally invasive surgery.

Dr. Rita Kandel - - MSH
The regeneration of musculoskeletal (bone and soft) tissue is Dr. Kandel’s second research focus. Specifically, Dr. Kandel’s Lab is attempting to build new tissues to replace human joints that are damaged by injury or disease. This means that a joint will no longer be replaced with a plastic or metal replica, but with one built from a patient’s own tissue and cells.

Dr. Peter Kim - - HSC
My lab is interested in investigating the basic governing principles and molecular and genetic mechanisms of body patterning and differentiation, using both chick and mouse embryo models. The current active areas of interest include development of foregut, hindgut and diaphragm.

Dr. Paulo Koeberle - - MSB
The focus of our research is the development of new ways to promote neuronal survival and regeneration in the injured central nervous system (CNS). We use the visual system to model traumatic and ischemic injury in the CNS as the retina is particularly well suited to study these processes. Our lab is also interested in the use of stem cells to replace injured retinal neurons.

Dr. Marius Locke - - KPE
The cellular response to muscle damage, including the regulation, expression and protection of stress/heat shock proteins/damage associated molecular patterns in striated muscle.

Dr. Cindi Morshead - - The Donnelly Centre
My lab works on adult neural stem cells from the mammalian central nervous system. Our research focuses on the fundamental characterization using a variety of techniques including live-cell imaging. We are using in vivo models of stroke and spinal cord injury to examine their role in regeneration. As well, we are interested in the extrinsic and intrinsic factors that regulate stem cells and their progeny in vivo and vitro.

Dr. Hee-Won Park - - MARS
My laboratory studies the structural aspects of intracellular protein and membrane trafficking pathways. Functional vesicular trafficking is central to normal cellular physiology. Ras-like proteins from rat brains (RABs) and ADP ribosylation factors (ARFs) are regulators of trafficking of proteins and membranes by acting as docking sites for an assembly of effecter molecules. Page

Dr. Philip Sherman - - HSC
My laboratory is characterizing host epithelial-cell signalling responses after infection with enterohaemorrhagic Escherichia coli O157:H7 and exposure to probiotics.

Dr. Earl Silverman - - HSC
Our lab studies paediatric systemic lupus erythematosus, neonatal lupus erythematosus and therapies in paediatric rheumatic diseases.

Dr. Hong-Shuo Sun - - MSB
Research in my lab is mainly focused on studying the role of ion channels in neuroprotection against cerebral ischemia and stroke, and identifying potential therapeutic targets for stroke.

Dr. Chen Wang - - MSH
The research in my lab concerns molecular & cellular aspects in normal hematopoesis and hematological disease. In addition, we examine human materials from patients to characterize the gene expression profile for clinical diagnosis and predictors or prognosis.

Dr. D. van der Kooy - - The Donnelly Centre
Pattern formation in the developing mammalian brain. Localization of brain sites mediating the euphoria induced by psychoactive drugs. Learning and memory in simple organisms.

Dr. E. Zacksenhaus - - TGH
The lab is using mouse models, cell and molecular biology to study breast cancer progression and tumor initiating cells, the role of the retinoblastoma tumor suppressor, pRb, in mammary gland development, breast cancer and skeletal myogenesis and the effect of pRb phosphorylation in vivo.


NOTE: This is not an exaustive list of labs willing to work with students on a research project. Please feel free to contact other labs you might be interested in working with.