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[([5)8(,6)8(])]TJ
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[(same comments appl)4.4(y to two r)11.1(e)-3.2(por)-7(t)-1.9(s for o)14.5(v)8.7(arian)]TJ
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[(car)11.5(c)-4.9(inoma )]TJ
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[(100% specificity and)]TJ
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[(sensitivi)5.5(t)-4.8(y )]TJ
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[([2)-9.6(])]TJ
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[(, b)-4.2(u)1.8(t )-6(none of the )-6(pea)-3.8(k)1.9(s a)-3.8(r)14.5(e )-6(the)]TJ
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[(same with thos)5.3(e initially identified in the ori)5.6(g)-4.2(-)]TJ
T*
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(inal )Tj
/F3 1 Tf
1.7651 0 TD
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(Lancet)Tj
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[( pa)-6.1(per )]TJ
6.96 0 0 6.96 445.74 487.4008 Tm
0 Tw
([1])Tj
9.96 0 0 9.96 453.72 487.4008 Tm
0 Tc
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[(. Al)-6(so, )6(k)-6(n)0.9(o)10.1(w)-2.7(n discrimina)-5.6(-)]TJ
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0.0019 Tc
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[(tor)-15.5(y)0.1( molecules, such)4.9( as)5.6( th)4.9(e classical pros)5.6(tate)]TJ
T*
0.0032 Tc
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[(a)3.6(n)-1.9(d)6.2( o)19.3(v)7.5(ar)3.9(ia)3.6(n )6(ca)3.6(nc)5.6(er)3.9( b)3.2(iomar)9.9(k)3.3(e)1.6(rs)6.9( p)4.2(r)3.9(osta)3.6(te-)3.9(s)0.9(pe-)]TJ
T*
0.0002 Tc
0.2498 Tw
[(cif)-5(i)4.2(c an)-4.9(tigen \()-5.1(P)1(S)-4.8(A)2.7(\))-5.1( an)-4.9(d can)-4.9(c)2.6(er)-5.1( ant)-6.1(i)4.2(g)-5.6(e)-1.4(n 12)-5.8(5)]TJ
T*
0.0018 Tc
0.2663 Tw
[(\(CA125\), hav)6.1(e)0.2( not )-6(been identifi)5.8(ed in pub-)]TJ
T*
0.0009 Tc
0.1407 Tw
[(lished r)7.6(e)-0.7(por)-10.5(t)0.7(s, sugg)-4.9(esting that this method is)]TJ
T*
0.2973 Tw
[(not )-6(sensitive at)-5.4( lo)11(w )-6(ana)-4.7(l)0.9(yte concent)-5.4(r)1.6(ation)-4.2(s)4.6(.)]TJ
T*
-0.016 Tw
[(Among the molecules that have )6(b)-5.1(een positively)]TJ
T*
0.0011 Tc
0.0802 Tw
[(identified b)7.1(y)-0.7( this technology a)-4.5(s)4.8( potentia)-4.5(l ne)-6.5(w)]TJ
T*
0.0016 Tc
0.0014 Tw
[(c)4(a)-4(ncer biomarkers, )6(most, if not all,)4.6( w)5(e)0(r)14.3(e)0( found)]TJ
T*
0.0014 Tc
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[([)-7.6(5,6])]TJ
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[(La)6.8(ncet)]TJ
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[(I)9.1(n)-2.7( my original comm)-5.7(entar)-21(y)0.7( on this technology)85(,)5.5( it was pr)9.2(o-)]TJ
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[(pose)-6.5(d )6(to the au)-4.9(thors to posit)-5.1(i)-0.9(vely)]TJ
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[( identify the na)-4.1(tu)-4.5(r)14.3(e)-6.1( )6(of )6(their)]TJ
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[(criminator)-15.5(y pe)-5.8(aks either )]TJ
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[(.)5( M)28.4(y)0.2( pr)8.7(ediction )6.1(is)]TJ
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[(Repr)17.2(o)-0.3(duction of)7.2( the metho)-7.8(d)]TJ
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[(in th)-5.3(e )]TJ
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[(b)5.4(y)3.6( other laboratories)]TJ
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[(on o)14.9(v)3(arian cancer )]TJ
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( )Tj
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[(ed to develop their method is)]TJ
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[(that ar)12.7(e )6(also capabl)6(e of positi)]TJ
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[([2)-9.6(])]TJ
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[(Ciphergen B)8(i)3.3(osystems, )-6(pr)6.1(oteomi)]TJ
13.1928 0 TD
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[(c )6(chips used to dev)9.6(e)-2.3(lop )6(the)]TJ
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[( method have no)14.8(w)-4( )6(been )6(di)]TJ
10.8434 0 TD
0.0099 Tc
0.0714 Tw
[(sc)-5.8(onti)-4.2(nued)-5.2(. Th)-5.2(ei)-4.2(r )6(ne)-9.8(w data)]TJ
-13.3675 -1.2048 TD
0.0108 Tc
0.0223 Tw
[(ar)11.5(e bas)-3.5(e)-2.8(d on differ)11.5(e)-2.8(nt ch)-4.3(ips)-3.5( )]TJ
6.96 0 0 6.96 146.04 236.1808 Tm
0.0076 Tc
0 Tw
[([2)-9.6(])]TJ
9.96 0 0 9.96 154.2 236.1808 Tm
0.0125 Tc
0.0206 Tw
[(.)3.5( This)4.2( info)4.5(rmati)4.4(o)-1.5(n im)4.3(plie)4.9(s that)]TJ
-12.0663 -1.2048 TD
0.0094 Tc
0.0237 Tw
[(it is)-4.9( no)13.5(w)-5.3( no)-4.6(t )6(p)-7.7(o)1.4(s)-4.9(s)1.1(i)-4.7(b)-2.6(le)-4.2( to repro)-4.6(d)0.3(uc)-6.3(e the)-4.2( o)-4.6(r)-2(igin)-7.8(al )]TJ
/F3 1 Tf
18.9759 0 TD
0.0126 Tc
0 Tw
[(La)4.8(ncet)]TJ
/F4 1 Tf
2.5301 0 TD
-0.0007 Tc
0.0338 Tw
[( re)-14.3(p)-11.8(o)-8.7(r)-24.1(t)-13(.)]TJ
-21.506 -1.2048 TD
0.0115 Tc
0.4252 Tw
[(P)54.5(e)3.9(tricoin III an)-5.7(d co)9.5(wor)6.1(k)-0.5(ers n)-5.7(o)15.6(w claim that)5.2( )-6.1(t)5.2(h)-3.6(ey hav)9.8(e)]TJ
T*
0.0123 Tc
-0.0274 Tw
[(s)4(e)-1.3(q)3.3(u)0.2(enced)3.2( )-6.1(t)6(h)-2.8(o)4.3(u)0.2(sand)3.2(s of cir)6.9(c)2.7(ulat)]TJ
12.5181 0 TD
0.0116 Tc
-0.0267 Tw
[(ing lo)9.6(w )-6.1(molecular w)8.9(e)-2(ig)5.8(ht pep-)]TJ
-12.5181 -1.2048 TD
0.0118 Tc
0.0213 Tw
[(tides )6(which, t)5.5(h)-3.3(ey postulat)5.5(e, may )6(r)6.5(e)4.2(pr)6.5(esent a tr)12.5(easur)12.5(e)-1.8( t)5.5(r)6.5(o)15.9(v)4(e )6(for)]TJ
T*
0.0124 Tc
0.0087 Tw
[(fut)6.1(u)0.3(r)7.1(e)4.8( d)3.3(i)-1.7(agno)4.4(sti)4.3(c)2.8(s )]TJ
6.96 0 0 6.96 106.8 176.1808 Tm
0.0167 Tc
0 Tw
[([1)8.1(1])]TJ
9.96 0 0 9.96 118.5 176.1808 Tm
0.0114 Tc
0.0097 Tw
[(. H)16.2(o)15.5(wev)9.7(e)-2.2(r)60.3(,)2.4( t)5.1(h)-3.7(ey)3.6( did no)3.4(t r)12.1(e)-2.2(po)3.4(r)-12(t)5.1( the )6(iden-)]TJ
-8.4819 -1.2048 TD
0.0999 Tw
[(tity of t)5.2(h)-3.6(e fiv)9.8(e)-2.1( discriminator)-17.9(y)3.7( peaks r)12.2(e)-2.1(por)-11.9(t)-0.8(ed )6(in the )6(orig)5.7(inal)]TJ
/F3 1 Tf
T*
0.0096 Tc
0 Tw
[(La)-4.2(ncet)]TJ
/F4 1 Tf
2.5241 0 TD
0.0116 Tc
0.1059 Tw
[( publication or in )6.1(their l)5.6(a)-0.1(test contribution )]TJ
6.96 0 0 6.96 235.32 152.1808 Tm
0.0076 Tc
0 Tw
[([2)-9.6(])]TJ
9.96 0 0 9.96 243.48 152.1808 Tm
0.0136 Tc
0.0978 Tw
[(. Cons)5.3(e-)]TJ
-21.0301 -1.2048 TD
0.0119 Tc
0.0875 Tw
[(quentl)5.9(y)82.4(,)2.9( the )]TJ
/F3 1 Tf
5.1265 0 TD
0.0136 Tc
0 Tw
[(La)5.8(ncet)]TJ
/F4 1 Tf
2.5301 0 TD
0.0994 Tc
[( )6(r)94.1(e)91.8(p)82.3(o)91.4(r)82(t)87.1( s)85.1(h)90.3(o)85.4(u)87.3(l)93.4(d)84.3( b)87.3(e)91.8( o)85.4(f)88.2( q)90.4(u)87.3(e)85.8(s)91.1(t)87.1(i)85.3(o)91.4(n)88.3(a)87.7(b)87.4(l)87.4(e)85.8( v)97.7(a)87.7(l)87.4(i)91.3(d)84.3(i)91.3(t)87.1(y)]TJ
-7.6566 -1.2048 TD
0.0108 Tc
0.0765 Tw
[(until t)4.5(h)-4.3(e identity of )6(the five )]TJ
11.7169 0 TD
0.0114 Tc
0.0699 Tw
[(discriminator)-18(y)-2.4( p)-5.7(e)3.8(aks is )-6.1(r)12.1(e)-2.2(v)9.7(e)-2.2(aled)]TJ
-11.7169 -1.2048 TD
0.0117 Tc
0.0214 Tw
[(and the method and )6(r)6.3(e)4.1(sul)5.7(t)-0.6(s )6(ar)6.3(e r)12.4(e)-1.9(pr)6.3(oduced b)5.7(y)-2.1( )6(others. )6(I)12.3(n)0.6( gen-)]TJ
T*
0.0123 Tc
0.0148 Tw
[(e)4.7(r)0.9(al, )-6(t)6(h)-2.8(e ex)4.5(peri)4.2(ence of other i)4.2(n)-4.9(v)10.6(e)-1.3(s)4(t)0(igat)6(ors)4( )-6(r)13(e)-1.3(gar)19(d)-2.8(i)4.2(n)1.2(g )-6(r)13(e)4.7(pr)6.9(o)4.3(d)-2.8(uc-)]TJ
T*
0.0131 Tc
0.273 Tw
[(i)5(b)1.1(il)7.1(ity)5.3( )-6.1(and )-6.1(lo)5.1(ng)7.3(-term r)7.8(o)-0.9(bus)4.8(t)0.8(nes)4.8(s)-1.2( of the)5.5( )-6.1(me)5.5(thod ha)7.5(s )-6.1(b)7.1(een)]TJ
T*
0.0124 Tc
0.0268 Tw
[(uns)4.1(a)0.7(ti)4.3(sfactor)-17(y)89(,)3.4( )-6(as)4.1( di)4.3(scus)4.1(se)4.8(d in d)3.3(e)-1.2(tai)4.3(l)0.4( b)6.4(y)-1.4( R)12.8(o)-1.6(ge)4.8(rs and)3.3( )-6(co)10.4(w)3.7(o)-1.6(r)7.1(k)0.4(e)4.8(r)1(s)]TJ
T*
0.0112 Tc
0.0039 Tw
[(for r)11.9(e)-2.4(nal)5.2( car)5.9(c)1.6(inoma )]TJ
6.96 0 0 6.96 113.4 68.1808 Tm
0.0081 Tc
0 Tw
[([12)-9.1(])]TJ
9.96 0 0 9.96 125.1 68.1808 Tm
0 Tc
(.)Tj
/F7 1 Tf
7.9999 0 0 8.46 289.14 717.2008 Tm
0.0071 Tc
-0.0096 Tw
[(Cl)7.1(i)7.1(n)-0.4(i)7.1(c)2.1(al v)27.1(a)7.1(li)7.1(dati)7.1(on)]TJ
/F4 1 Tf
9.96 0 0 9.96 289.14 704.1808 Tm
-0.0012 Tc
0.0705 Tw
[(P)53.8(e)3.2(tricoin III)]TJ
/F3 1 Tf
4.7651 0 TD
0 Tc
0 Tw
( )Tj
/F4 1 Tf
0.3193 0 TD
-0.0014 Tc
0.0707 Tw
[(and co)14.7(wor)5.3(k)4.7(ers ar)11.3(e no)8.7(w pursuing a clinical v)8.9(a)-1(lida-)]TJ
-5.0843 -1.2048 TD
-0.0019 Tc
0.035 Tw
[(tion of the o)14.2(v)2.4(a)4.5(r)-1.2(ian cancer dia)4.5(g)-1.7(no)]TJ
12.8373 0 TD
-0.0009 Tc
0.028 Tw
[(stic )-6(method b)5.1(y)-2.7( coll)5.1(ecting dat)4.9(a)]TJ
-12.8373 -1.2048 TD
-0.0002 Tc
0.1116 Tw
[(suitab)5.8(le )6(for)6.5( a US )6(F)31.8(o)3.9(od a)6.2(n)0.7(d D)14.7(r)-5.5(ug )6(A)8.3(d)2.8(minist)5.6(rat)5.6(i)-2.2(on \(FDA\))6.5( su)5.8(b-)]TJ
T*
-0.0033 Tc
0.2292 Tw
[(mi)-5.3(ssi)-5.3(on. H)13.5(o)12.8(wever)57.6(,)-0.3( th)-6.4(ey)-5.1( )6(ar)9.4(e)-4.9( )6(no)]TJ
12.5 0 TD
-0.0015 Tc
0.2274 Tw
[(w concentra)4.9(t)-1.7(ing not on early)]TJ
-12.5 -1.2048 TD
-0.0011 Tc
0.0403 Tw
[(o)15(v)9.2(arian cancer)5.6( )-6(diagnosis but ra)5.3(th)]TJ
12.7952 0 TD
0.0001 Tc
0.0391 Tw
[(er o)4.2(n)1( )-6(de)4.5(te)4.5(ct)5.9(in)7(g o)16.2(v)4.4(ar)6.8(ia)6.5(n )-6(cance)4.5(r)]TJ
-12.7952 -1.2048 TD
0.0029 Tw
[(r)12.8(e)4.5(laps)3.8(e. Cle)4.5(a)0.5(rly)88.7(,)3.1( the cl)6.1(ini)4.1(c)2.5(al v)10.4(a)0.5(l)6.1(u)0.1(e o)4.2(f)0.9( det)5.9(e)-1.5(cti)4.1(n)1(g e)4.5(a)0.5(rly)4.4( r)12.8(e)-1.5(l)6.1(a)0.5(ps)3.8(e i)4.1(s)-2.2( f)7(a)0.5(r)]TJ
T*
-0.0031 Tc
-0.0059 Tw
[(inferi)-5.1(or )6.1(in com)-5.3(p)-2.1(ari)-5.1(s)0.6(on with earl)]TJ
12.1807 0 TD
-0.0013 Tc
-0.0138 Tw
[(y o)14.8(v)9(arian cancer diagnosis )-6.1(since,)]TJ
-12.1807 -1.2048 TD
-0.0031 Tc
0.0121 Tw
[(as it is)-5.4( wi)-5.1(dely )-6.1(kno)7(w)0.3(n, the)-4.7(r)9.6(e )-6.1(are no)-5( effective s)-5.4(a)3.3(lvage)-4.7( th)-6.2(erapies)-5.4( for)]TJ
T*
-0.0051 Tc
0.3214 Tw
[(r)7.6(e)-0.7(l)-5.1(a)-4.7(p)-4.1(s)-1.4(in)-4.2(g)-4.9( o)11(v)-0.8(ar)-4.4(i)-7.1(a)1.3(n)-4.2( c)-8.7(a)1.3(rci)-7.1(n)-4.2(om)-7.3(a.)-8.1( De)-6.7(sp)-4.1(it)-5.3(e c)-8.7(u)0.9(r)-4.4(r)7.6(e)-6.7(n)-4.2(t )-6(ava)-4.7(i)-1.1(l)-5.1(a)1.3(b)-5.1(i)-7.1(lit)-5.3(y)-6.9( of)]TJ
T*
-0.0014 Tc
-0.0197 Tw
[(al)4.6(ternativ)8.9(e and r)11.3(e)-3(l)4.6(a)-1(tively )-6(effici)]TJ
11.4157 0 TD
-0.0018 Tc
-0.0193 Tw
[(ent m)-4(e)-3.4(tho)-3.8(d)1.2(s)-4.1( for )-6(early )-6(o)20.3(v)2.5(arian can-)]TJ
-11.4157 -1.2048 TD
-0.0021 Tc
0.2461 Tw
[(cer relapse d)-5.1(e)2.3(tection \(imaging )]TJ
12.6807 0 TD
[(tec)-5.6(h)0.9(niques and s)-4.3(e)2.4(rial CA)-5.5(125)]TJ
-12.6807 -1.2048 TD
-0.0004 Tc
-0.0026 Tw
[(ana)6(l)-0.4(ys)3.3(i)3.6(s)3.3(\), thes)3.3(e m)3.5(o)-2.4(dal)5.6(i)-2.4(t)5.4(i)-2.4(e)4(s)-2.7( a)6(r)6.3(e)4( )]TJ
11.4639 0 TD
-0.0015 Tc
-0.0015 Tw
(not contributing mu)Tj
7.9398 0 TD
-0.0039 Tc
0.0009 Tw
[(ch)-7( to)-5.9( ex)-5.6(te)-5.5(nd-)]TJ
-19.4036 -1.2048 TD
-0.0019 Tc
0.0712 Tw
[(ing o)14.2(v)8.4(arian canc)-5.5(er sur)-19.3(v)2.4(ival o)-3.9(r)4.8( qual)]TJ
13.4759 0 TD
-0.0026 Tc
0.0719 Tw
[(ity of life. I)22.1(t)-2.8( is of interest to)]TJ
-13.4759 -1.2048 TD
-0.0027 Tc
0.1985 Tw
[(ex)-4.4(amine)-4.3( why)-4.5( th)-5.8(e focus of the m)-4.9(e)1.7(tho)-4.6(d)0.3( no)13.4(w)-5.4( )6(appears to have)]TJ
T*
-0.0001 Tc
-0.0029 Tw
[(change)4.3(d fr)12.6(om)3.8( )-6(e)4.3(a)0.3(rl)5.9(y di)3.9(agnos)3.6(i)3.9(s)3.6( )-6(t)5.7(o)-2.1( det)5.7(e)-1.7(ct)5.7(io)4(n of r)12.6(e)4.3(cu)5.9(rr)12.6(ence)4.3(.)]TJ
0.8554 -1.2048 TD
0.0012 Tc
0.2488 Tw
[(I)13.9(n)2.1( the mea)-4.4(n)2.1(time, the Ear)-4.2(l)1.2(y Detection R)13.7(e)-0.4(search N)31.2(e)-0.4(twork)]TJ
-0.8554 -1.2048 TD
0.002 Tc
0.1516 Tw
[(\(EDRN\) )6(of the N)32(a)2.4(ti)6(onal Cancer)]TJ
13.2048 0 TD
0.0017 Tc
0.1519 Tw
[( I)14.4(n)-3.4(stitute has )6(embraced )6(this)]TJ
-13.2048 -1.2048 TD
0.0019 Tc
0.1095 Tw
[(ne)-5.7(w technology as)5.6( one of the most pr)8.6(omising appr)8.6(oaches)5.6( for)]TJ
T*
0.0004 Tc
0.1351 Tw
[(earl)-5.6(y o)16.5(v)4.7(ar)-4.9(ia)-5.2(n a)-5.2(n)1.3(d other can)-4.7(c)2.8(er)-5( )]TJ
12.5361 0 TD
0.0021 Tc
0.1334 Tw
[(di)6.1(agnosis and has initiated an)]TJ
-12.5361 -1.2048 TD
0.0006 Tc
0.2313 Tw
[(effor)-10.8(t)0.4( to standa)-5(r)13.3(d)3.6(ize the )6(m)-7.6(e)-1(th)]TJ
12.4036 0 TD
0.0019 Tc
0.224 Tw
[(odology in v)6.2(a)-3.7(rious )-6(biomar)8.6(ker)]TJ
-12.4036 -1.2048 TD
0.0005 Tc
0.2495 Tw
[(validation)-4.6( la)-5.1(bora)-5.1(tories. )-6(These )]TJ
12.3855 0 TD
0.0016 Tc
0.2544 Tw
[(centers)5.3( ar)8.3(e using )6(the original)]TJ
-12.3855 -1.2048 TD
0.0017 Tc
0.3507 Tw
[(instr)-9.7(u)1.7(mentation )-6(proposed by P)50.7(e)0.1(trico)5.8(i)-0.3(n III )-6(and co)11.8(wor)8.4(k)1.8(ers)5.4(,)]TJ
T*
-0.0028 Tc
-0.0062 Tw
[(w)-5.5(h)-5.9(ic)-6.4(h)-5.9( is)-5.1( n)-7.9(o)13.3(w)-5.5( c)-6.4(o)-4.8(ns)-5.1(i)-4.8(d)-5.9(e)-4.4(r)9.9(e)-4.4(d)-5.9( s)-5.1(ubo)-4.8(p)-7.8(t)-3(i)-4.8(m)-5(al )]TJ
6.96 0 0 6.96 431.4 440.1808 Tm
-0.0005 Tc
0 Tw
([2])Tj
9.96 0 0 9.96 439.38 440.1808 Tm
0.0008 Tc
-0.0098 Tw
[(. I)19.5(t)0.6( )6.1(is thus likely that the)]TJ
-6.8554 -1.2048 TD
0.0018 Tc
0.2422 Tw
[(efforts)5.5( of EDRN may become obsolete)]TJ
T*
0.0011 Tc
0.0019 Tw
[(bef)-4.1(o)-0.9(r)13.8(e)-0.5( this )6(eval)-4.9(uation is )6(completed.)]TJ
0.8554 -1.2048 TD
0.0026 Tc
0.0486 Tw
[(I)15.3(n)-2.5( )6(a )6(r)9.3(e)1(port in The )6(N)26.6(e)-5(w Y)94.7(o)0.6(r)9.3(k)2.7( T)42.1(i)0.6(mes on)]TJ
-0.8554 -1.2048 TD
0.0002 Tc
0.2859 Tw
[(F)32.2(e)-1.4(br)-11.2(uar)-23.2(y)-1.6( 3r)12.9(d, 2)-5.8(004, )-6.1(it)-6.1( was )-6.1(ann)-4.9(o)-1.8(un)-4.9(ced)]TJ
T*
0.0016 Tc
0.4592 Tw
[(that Corr)8.3(elogic S)8.7(y)-0.2(stems \(MD, )-6.1(USA\),)]TJ
T*
0.0018 Tc
0.1398 Tw
[(which dev)6.1(e)0.2(loped the bioinformati)5.8(c)-1.8( algo-)]TJ
T*
0.0015 Tc
-0.0166 Tw
[(r)-3.9(i)5.5(thm of )6(the )]TJ
/F3 1 Tf
4.9036 0 TD
0.0008 Tc
0 Tw
(Lancet )Tj
/F4 1 Tf
2.6988 0 TD
0.0017 Tc
-0.0228 Tw
[(paper)62.6(,)-1.3( has licenced the)]TJ
-15.8313 -1.2048 TD
0.001 Tc
-0.01 Tw
[(o)17.1(v)5.3(ar)-4.3(ian cancer )6.1(test \(kno)11.1(wn )6.1(a)-4.6(s)4.7( OvaCheck\) to )6.1(Quest )6.1(D)9.9(i)-1(agnos-)]TJ
T*
0.1175 Tc
0 Tw
[(t)117.3(i)115.5(c)119.9(s)115.2( \()112.2(N)117.4(J)113.1(,)120.5( U)116.5(S)112.5(A)114(\))118.2( a)117.9(n)112.4(d)114.4( L)116.3(a)117.9(b)117.5(C)114.7(o)115.6(r)112.2(p)136.5(.)114.5( )]TJ
12.1867 0 TD
0.0013 Tc
0.1162 Tw
[(\(NC, )-6(USA\), the largest priv)5.6(ate)]TJ
-12.1867 -1.2048 TD
0.0011 Tc
0.1043 Tw
[(lab)-4.9(o)-0.8(rator)-4.2(i)5.1(es in the )6(USA, for)-4.2( )6(commer)7.8(c)-2.5(ial use. The )6(t)-5.2(e)5.5(st will be)]TJ
T*
0.0013 Tc
0.068 Tw
[(offer)8(e)-0.3(d to )-6(women )-6(at )-6(high )-6(risk, despite n)-3.8(o)-0.7( FDA ap)-3.7(pr)8(o)11.4(v)5.6(al. The)]TJ
T*
0.0019 Tc
0.0373 Tw
[(test has been adv)6.2(e)0.3(rtised to gynecolo)6(gic oncologis)5.6(t)1.7(s at the 2004)]TJ
T*
0.002 Tc
0.007 Tw
[(annual meeting on)]TJ
/F3 1 Tf
7.2831 0 TD
-0.0768 Tc
0.0858 Tw
[( Wo)-80.4(m)-76.7(e)-80.2(n)32.6()-43.5(s)-79.9( C)-75.4(a)-78.6(n)-75.8(c)-76.1(e)-80.2(r)]TJ
/F4 1 Tf
6.1988 0 TD
0.0001 Tc
0.0089 Tw
[(, or)-5.2(gan)-5(i)-1.9(z)9.6(e)-1.5(d)-2.9( by th)-3(e S)13.2(o)-1.9(c)-3.5(i)-1.9(et)-6.2(y of)]TJ
-13.4819 -1.2048 TD
0.0012 Tc
0.1705 Tw
[(G)13.3(y)-0.6(n)-3.9(e)-0.4(colog)-4.6(i)5.2(c )-6(O)7(n)-3.9(colog)-4.6(i)5.2(st )-6(\(U)-5.8(SA\). I)19.9(t)1( is )-6(unclea)-4.4(r wha)-4.4(t)1( a)-4.4( woma)-4.4(n)]TJ
T*
0.0006 Tc
0.0446 Tw
[(would do if the test is positive)]TJ
11.8434 0 TD
0.0014 Tc
0.0438 Tw
[(. )6(The risk is that without kno)11.5(w)-1.2(-)]TJ
-11.8434 -1.2048 TD
0.0007 Tc
0.0505 Tw
[(ing )-6(the )-6(positive pr)7.4(edictive valu)-5.4(e of the test, many women )-6(may)]TJ
T*
0.0008 Tc
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