Publications

Ali, S.S., Soo, J., Rao, C., Leung, A.S., Ngai, D.H-M., Ensminger, A.W., and W.W. Navarre. (2014) Silencing by H-NS potentiated the evolution of Salmonella.  PLoS Pathogens 10(11): e1004500. doi:10.1371/journal.ppat.1004500.

Will, W.R., Navarre, W.W., and F.C. Fang (2014) Integrated Circuits: How Transcriptional Silencing and Counter-Silencing Facilitate Bacterial Evolution.  Current Opinion in Microbiology (in press)

Wang, H., Epstein, S., Ali, S.S., Navarre, W.W. and J. Milstein (2014) A biomechanical mechanism for initiating DNA packaging.  Nucleic Acids Research doi: 10.1093/nar/gku896

Hersch, S.J., Elgamal, S., Katz, A., Ibba, M., and W.W. Navarre (2014) Translation Initiation Rate Determines the Impact of Ribosome Stalling on Bacterial Protein Synthesis. Journal of Biological Chemistry 289(41):28160-28171

Elgamal, S., Katz, A., Hersch, S.J., Newsom, D., White, P., Navarre, W.W. and M. Ibba (2014) EF-P dependent pauses integrate proximal and distal signals during translation. PLoS Genetics 10(8):e1004553. doi:10.1371/journal.pgen.1004553

Belcheva, A., Irrazabal, T., Robertson, S.J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E.H., Copeland, J.K., Kumar, S., Green, B., Geddes, K., Pezo, R.C., Navarre, W.W., Milosevic, M., Wilson, B.C., Girardin, S.E., Wolever, T.M., Edelmann, W., Guttman, D.S., Philpott, D.J. and A. Martin. (2014)  Gut microbial metabolism drives transformation of Msh2-deficient colon epithelial cells.  Cell 158(2):288-99

Katz, A., Solden, L., Zou, S.B., Navarre W.W., and M. Ibba (2014) Molecular evolution of protein-RNA mimicry as a mechanism for translational control. Nucleic Acids Research 42(5):3261-3271

Hersch, S.J., Wang, M., Zou, S.B., Moon, K-M., Foster, L.J., Ibba, M., and W.W. Navarre (2013) Divergent protein motifs direct EF-P mediated translational regulation in Salmonella and E. coli.  mBio 4(2) e00180-13.  doi: 10.1128/mBio.00180-13

Ali, S.S., Whitney, J.C., Stevenson, J., Robinson, H., Howell, P.L., and W.W. Navarre (2013) Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex. Journal of Biological Chemistry 288(19):13356-13369

Bullwinkle, T.J., Zou, S.B., Rajkovic, A., Hersch, S.J., Elgamal, S., Robinson, N., Smil, D., Navarre, W.W., and M. Ibba (2013) (R)-beta-lysine modified elongation factor P functions in translation elongation.  Journal of Biological Chemistry. 288(6):4416-4423

Ibba, M. and W.W. Navarre (2012) Elongation Factor P – Putting a eukaryotic twist on bacterial gene expression.  Microbe 7(10) 449-454

Ali, S.S., Xia, B., Liu, J., and W. W. Navarre (2012) Silencing of foreign DNA in bacteria. Current Opinion in Microbiology 15(2):175-181

Zou, S.B., Hersch, S.J., Roy, H., Wiggers, J.B., Leung, A.L., Buranyi, S.G., Xie, J.L., Dare, K., Ibba, M., and W.W. Navarre (2012) Loss of elongation factor P disrupts bacterial outer membrane integrity. Journal of Bacteriology 194(2):413-425    * Note: Authors correction in Journal of Bacteriology (2012), 194(16):4484.

Glireath, M.S., Roy, H., Bullwinkle, T.J., Katz, A., Navarre, W.W. and M. Ibba (2011) Beta-lysine discrimination by lysyl-tRNA synthetase. FEBS Journal 585(20):3284-3288

Roy, H., Zou S.B., Bullwinkle, T.B., Wolfe, B.S., Gilreath, M.S., Forsyth, C.J., Navarre, W.W., and M. Ibba  (2011) The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine. Nature Chemical Biology, 7(10):667-669

Ali, S.S., Beckett, E., Bae, S.J., and W.W. Navarre (2011) The 5.5 protein of phage T7 inhibits H-NS through interactions with the central oligomerization domain. Journal of Bacteriology, 193(18):4881-4892

Gordon, B.R., Li, Y., Cote, A., Weirauch, M., Ding, P., Hughes, T., Navarre, W.W., Xia, B. and J. Liu (2011) Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins.  Proc. Natl. Acad. Sci. USA. 108(26):10690-10695

Zou, S.B., Roy, H., Ibba, M., and W.W. Navarre (2011) Elongation Factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence.  Virulence 2(2): 147-51.

Navarre, W.W*., Zou, S., Roy, H., Xie, J.L., Savchenko, A., Singer, A., Edvokimova, E., Prost, L.R., Kumar, R., Ibba, M. Fang, F.C. (2010) PoxA, YjeK and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella enterica. Molecular Cell, 39(2):209-221 (*sole corresponding author)

Gordon, B.R., Li, Y., Wang, L., Sintsova, A., van Bakel, H., Tian, S., Navarre, W.W., Xia, B., and J. Liu  (2010) Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA. 107(11):5154-5159

Navarre, W.W. (2010) H-NS as a Defence System. in Bacterial Chromatin (editors: Dame R.T. and Dorman C.J.), Springer press. p.p. 251-322

Gordon, B.R., Imperial, R., Wang, L., Navarre, W.W. and J. Liu (2008) Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins. Journal of Bacteriology 190(21):7052-7059

Noom, M.C., Navarre, W.W., Oshima, T., Wuite, G.J.L, and R.T. Dame (2007) H-NS promotes looped domain formation in the bacterial chromosome.  Current Biology  17(21):R913-R914.


NAVARRE POST-DOCTORAL WORK FROM FANG LAB

Richardson, A.R., Payne, E.C., Younger, N., Karlinsey, J.E., Thomas, V.C., Becker, L.A., Navarre, W.W., Castor, M.E., Libby S.J., and F.C. Fang (2011)  Multiple Targets of Nitric Oxide in the Tricarboxylic Acid (TCA) Cycle of Salmonella enterica Serovar Typhimurium. Cell Host & Microbe, 10(1):33-43

Walthers, D., Carroll, R.K., Navarre, W.W., Libby, S.J., Fang, F.C., and L. Kenney. (2007)  The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS. Mol. Microbiol. 65(2):477-493

Navarre, W.W., McClelland, M., Libby, S.J., and F.C. Fang. (2007)  Silencing of xenogeneic DNA by H-NS - facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA (Review).  Genes Dev. 21(12):1456-1471.

Navarre, W.W., Porwollik, S., Wang, Y., McClelland, M., Rosen, H., Libby, S.J., and F.C. Fang. (2006) The H-NS protein selectively silences foreign DNA with low GC content in Salmonella.  Science 313(5784):236-238

Navarre, W.W., Halsey T.A., Walthers, D., Frye, J., McClelland, M., Potter, J., Kenney, L., Gunn, J.S., Fang, F.C., and S.J. Libby (2005) Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ. Mol. Microbiol.  56(2):492-508

Monsieurs, P., De Keersmaecker, S., Navarre, W.W., Bader, M., De Smet, F., McClelland, M., Fang, F.C., De Moor, B., Vanderleyden, J., and K. Marchal (2005) Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium.  J. Mol. Evol. 60(4):462-474

Bader, M.W., Navarre, W.W., Siau, W., Nikaido, H., Frye, J., McClelland, M., Fang, F.C. and S.I. Miller (2003) Regulation of Salmonella typhimurium Virulence Gene Expression by Cationic Antimicrobial Peptides.  Mol. Microbiol.  50(1): 219-230


NAVARRE POST-DOCTORAL WORK FROM ZYCHLINSKY LAB

Monack D.M., Navarre W.W. and S. Falkow (2001) Salmonella-induced macrophage death: the role of caspase-1 in death and inflammation (Review). Microbes Infect. 3(14-15):1201-1212

Navarre W.W. and A. Zychlinsky (2000) Pathogen-induced apoptosis of macrophages: a common end for different pathogenic strategies (Review).  Cell Microbiol. 2(4):265-273


Dr. Navarre’s Graduate Work in the lab of Olaf Schneewind:

Navarre, W.W., Ton-That, H., Faull, K. and O. Schneewind (1999) Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi-11. Identification of a D-alanyl-glycine endopeptidase activity.  J. Biol. Chem. 274(22): 15847-15856

Navarre, W.W. and O. Schneewind (1999) Protein targeting mechanisms to the cell wall of Gram-positive bacteria (Review).  Microbiol. Mol. Biol. Rev., 63(1): 174-229

Navarre, W.W., Ton-That, H., Faull, K. and O. Schneewind (1998) Anchor structure of surface proteins in Staphylococcus aureus.  Analysis of muramidase released anchor peptides.  J. Biol. Chem., 273(44): 29135-29142

Navarre, W.W., Daefler, S. and O. Schneewind (1996) Cell wall sorting of lipoproteins in Staphylococcus aureus. J. Bacteriol., 178(2): 441-446

Emami, K.H., Navarre, W.W. and S.T. Smale (1995) Core promoter specificities of the Sp1 and VP16 transcriptional activation domains.  Mol. Cell. Biol., 15(11): 5906-5916

Navarre, W.W. and O. Schneewind (1994) Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in Gram-positive bacteria.  Mol. Microbiol., 14(1): 115-121


Navarre lab - university of Toronto