Apr 27, 2015

An end to cancer pain?

A new study led by University of Toronto researcher Dr. David Lam has discovered the trigger behind the most severe forms of cancer pain.
Apr 14, 2015

Announcement: Dr. Mike Salter appointed Chief of Research at the Hospital for Sick Children

Dr. Mike Apok, President and CEO at the Hospital for Sick Children announces the appointment of Dr. Michael Salter to the position of Chief of Research:
Nov 21, 2014

Toronto General Hospital program uses new methods to prevent pain killer addictions after surgery

Acupuncture, exercise, psychological techniques and non-opioid pain medications used to prevent patients from developing chronic pain.


Canadian Pain Society 36th Annual Scientific Meeting

May 20-23, 2015
The Delta Prince Edward Hotel
Charlottetown, Prince Edward Island
For more information and to register, please click on the LINK

Pain Management: The Role of Opioids, Addiction Medicine and "End of Life" Decisions

12th Annual Pain Day Event - Queen's University
June 18, 2015

This is a multidisciplinary conference featuring leading experts in chronic pain management
For program details and to register, please click on the LINK
Click HERE for a registration form

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

Apr 24, 2015

<it>In situ</it> patch-clamp recordings from Merkel cells in rat whisker hair follicles, an experimental protocol for studying tactile transduction in tactile-end organs

Mammals use tactile end-organs to perform sensory tasks such as environmental exploration, social interaction, and tactile discrimination. However, cellular and molecular mechanisms underlying tactile transduction in tactile end-organs remain poorly understood.
Apr 21, 2015

Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin

The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches.
Apr 21, 2015

Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders

Laser in-situ keratomileusis (LASIK) is a commonly performed surgical procedure used to correct refractive error. LASIK surgery involves cutting a corneal flap and ablating the stroma underneath, with known damage to corneal nerves.
Apr 21, 2015

<it>In vivo</it> patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn

Transient receptor potential (TRP) channels are nonselective cation channels expressed in a variety of sensory structures, and are important molecular mediators of thermal, mechanical, cellular and chemical signals. We investigated the function of one key member of the TRP superfamily, TRPA1, in the spinal dorsal horn using in vivo patch-clamp recordings.
Apr 11, 2015

MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway

The Methyl CpG binding protein 2 gene (MeCP2 gene) encodes a critical transcriptional repressor and is widely expressed in mammalian neurons. MeCP2 plays a critical role in neuronal differentiation, neural development, and synaptic plasticity.
Apr 9, 2015

Lack of evidence for ectopic sprouting of genetically labeled A&#946; touch afferents in inflammatory and neuropathic trigeminal pain

Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies had suggested that aberrant axon sprouting from touch sensory afferents into pain-processing laminae after injury is a possible anatomical substrate underlying mechanical allodynia.