Sep 28, 2016

Variability in fMRI BOLD signal is a novel indicator of pain sensitivity and coping

Dr. Karen Davis and PhD student Anton Rogachov have recently discovered that regional blood oxygen level-dependent (BOLD) signal variability is a novel indicator of pain sensitivity and coping. Published online by PAIN in July, this study is the first to demonstrate a link between neural signal variability and an individual’s acute pain sensitivity and ability to cope with pain.
Sep 28, 2016

Connaught Summer Institute in Pain keynote lecture: Inhibition of tetrahydrobiopterin synthesis alleviates neuropathic and inflammatory pain

The Connaught Summer Institute in Pain brought pain research trainees from across the globe to Toronto to learn about the integration of research and clinical practice. The weeklong pain school culminated in a scientific meeting with keynote speaker Dr. Clifford Woolf, a renowned preclinical pain researcher based out of Boston Children's Hospital and Harvard University. Dr. Woolf discussed his recent research published in Neuron which highlighted the potential viability of targeting the tetrahydrobiopterin (BH4) synthesis pathway to treat inflammatory and neuropathic pain in humans.
May 6, 2016

Poor Pain Outcomes After Musculoskeletal Surgery Can Be Predicted By Post-Injury Anxiety and PTSD

New clinical research from UTCSP members Dr. Colin McCartney and Dr. Joel Katz, and PhD candidate Brittany Rosenbloom helps to shed light on the vulnerabilities in patients that may predispose them to have poor pain outcomes, including development of chronic neuropathic pain.
May 6, 2016

Cognitive Behavioural Training for Pain: Does it Change your Brain?

UTCSP member Dr. Karen Davis and her colleagues, Drs. Aaron Kucyi and Tim Salomons, recently reported in PAIN on differences in the brain function of healthy individuals via fMRI before and after cognitive behavioural training and repeated painful heat stimulus application.
May 5, 2016


Congratulations to Dr. Ze'ev Seltzer who was recently awarded an Honorary Professorship at the University of Heidelberg, Germany.
Mar 16, 2016

Neural Mechanisms Underlying Anxiety-Chronic Pain Interactions

In a recent article in Trends in Neuroscience, Dr. Min Zhuo discusses the link between anxiety and chronic pain. While chronic pain and anxiety are often comorbid, and treating anxiety can result in a reduction in pain, these conditions are usually studied separately. Dr. Zhuo proposes that these conditions are related via long-term potentiation (LTP) mechanisms in the anterior cingulate cortex (ACC).
Mar 16, 2016

The Periaqueductal Gray Matter: Sub-regions and Functional Connectivity with Descending Pain Modulation Circuitry

The experience of pain is highly variable between individuals for a multitude of physiological and psychological reasons. Evidence now suggests that part of this variability is due to interactions between ascending nociceptive signaling pathways and descending modulatory circuitry. The periaqueductal gray matter (PAG) is a critical brain region involved in top-down modulatory circuits. The laboratory of Dr. Karen Davis, and post-doctoral fellow Dr. Marie-Andree Colulombe recently investigated sub-regions of the PAG and their functional connectivity with other brain regions involved in pain processing.


Conquering the Hurt- Pain Connections - Body, Mind and Spirit

Registration now open!
November 10, 2016
Peter Gilgan Centre for Research and Learning
Hospital for Sick Children
686 Bay Street, Toronto
Webinar sign-up also available


UTCSP Annual Scientific Meeting
Tuesday, February 28, 2017
8:00 a.m. - 1:00 P.M.
Toronto Rehabilitation Institute
550 University Avenue
*Further details will be announced shortly

IASP's Global Year Against Pain in the Joints

January marks the launch of IASP's 2016 Global Year Against Pain in the Joints.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Sep 9, 2016

Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model

Wen-bo Kang, Qi Yang, Yan-yan Guo, Lu Wang, Dong-sheng Wang, Qiang Cheng, Xiao-ming Li, Jun Tang, Jian-ning Zhao, Gang Liu, Min Zhuo, Ming-gao Zhao
Sep 9, 2016; 12:174480691-174480691
Research Article
Sep 5, 2016

Downregulation of miR-219 enhances brain-derived neurotrophic factor production in mouse dorsal root ganglia to mediate morphine analgesic tolerance by upregulating CaMKII{gamma}

Xue-Ming Hu, Shou-Bin Cao, Hai-Long Zhang, Dong-Mei Lyu, Li-Ping Chen, Heng Xu, Zhi-Qiang Pan, Wen Shen
Sep 5, 2016; 12:174480691-174480691
Research Article
Sep 2, 2016

BDNF signaling contributes to oral cancer pain in a preclinical orthotopic rodent model

Leah Chodroff, Michelle Bendele, Vanessa Valenzuela, Michael Henry, Shivani Ruparel
Sep 2, 2016; 12:174480691-174480691
Research Article
Sep 2, 2016

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-{alpha} up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opioid receptors-mediated antiallodinic effect

Nunzio Vicario, Rosalba Parenti, Giuseppina Arico, Rita Turnaturi, Giovanna Maria Scoto, Santina Chiechio, Carmela Parenti
Sep 2, 2016; 12:174480691-174480691
Short Report
Sep 2, 2016

Ganglioside GM3 synthase depletion reverses neuropathic pain and small fiber neuropathy in diet-induced diabetic mice

Daniela M Menichella, Nirupa D Jayaraj, Heather M Wilson, Dongjun Ren, Kelsey Flood, Xiao-Qi Wang, Andrew Shum, Richard J Miller, Amy S Paller
Sep 2, 2016; 12:174480691-174480691
Research Article
Sep 2, 2016

A SCN10A SNP biases human pain sensitivity

Guangyou Duan, Chongyang Han, Qingli Wang, Shanna Guo, Yuhao Zhang, Ying Ying, Penghao Huang, Li Zhang, Lawrence Macala, Palak Shah, Mi Zhang, Ningbo Li, Sulayman D Dib-Hajj, Stephen G Waxman, Xianwei Zhang
Sep 2, 2016; 12:174480691-174480691
Research Article