May 6, 2016

Poor Pain Outcomes after Musculoskeletal Surgery can be Predicted by Post-Injury Anxiety and PTSD

New clinical research from UTCSP members Dr. Colin McCartney and Dr. Joel Katz, and PhD candidate Brittany Rosenbloom helps to shed light on the vulnerabilities in patients that may predispose them to have poor pain outcomes, including development of chronic neuropathic pain.
May 6, 2016

Cognitive Behavioural Training for Pain: Does it Change your Brain?

UTCSP member Dr. Karen Davis and her colleagues, Drs. Aaron Kucyi and Tim Salomons, recently reported in PAIN on differences in the brain function of healthy individuals via fMRI before and after cognitive behavioural training and repeated painful heat stimulus application.
May 5, 2016


Congratulations to Dr. Ze'ev Seltzer who was recently awarded an Honorary Professorship at the University of Heidelberg, Germany.
Mar 16, 2016

Neural Mechanisms Underlying Anxiety-Chronic Pain Interactions

In a recent article in Trends in Neuroscience, Dr. Min Zhuo discusses the link between anxiety and chronic pain. While chronic pain and anxiety are often comorbid, and treating anxiety can result in a reduction in pain, these conditions are usually studied separately. Dr. Zhuo proposes that these conditions are related via long-term potentiation (LTP) mechanisms in the anterior cingulate cortex (ACC).
Mar 16, 2016

The Periaqueductal Gray Matter: Sub-regions and Functional Connectivity with Descending Pain Modulation Circuitry

The experience of pain is highly variable between individuals for a multitude of physiological and psychological reasons. Evidence now suggests that part of this variability is due to interactions between ascending nociceptive signaling pathways and descending modulatory circuitry. The periaqueductal gray matter (PAG) is a critical brain region involved in top-down modulatory circuits. The laboratory of Dr. Karen Davis, and post-doctoral fellow Dr. Marie-Andree Colulombe recently investigated sub-regions of the PAG and their functional connectivity with other brain regions involved in pain processing.
Jan 20, 2016

Longitudinal Study of Catastrophizing, Pain and Cortical Thickness in Chronic Pain Patients

Neuropathic pain is a common chronic pain condition, which occurs following peripheral nerve injury (PNI). It is currently unknown why only some individuals with PNI develop chronic pain. However, it is predicted that both biological and psychological factors contribute to this process. The laboratory of Dr. Karen Davis recently conducted a longitudinal investigation of pan catastrophizing (i.e., when an individual has exaggerated negative thinking about painful experiences) and insula gray matter changes in patients with nerve injury.
Jan 20, 2016

Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms

Kasey Hemington, Keith Wu, Aaron Kucyi, Robert Inman and Karen Davis recently published a neuroimaging study, characterizing abnormalities between functional brain networks in chronic pain patients. The authors used resting state, functional magnetic resonance imaging to uncover abnormal connections between functional networks that were closely related to clinical symptom severity.


2016/17 UTCSP Pain Scientist Scholarship

Application DeadlineJuly 15, 2016
For complete Award details and application forms, please click on the following link

Connaught Summer Institute In Pain Annual Scientific Meeting: Integrating Research and Clinical Practice

July 22, 2016
8:00 a.m. to 1:30 p.m.

Peter Gilgan Centre for Research and Learning
686 Bay Street, Toronto

Postdoctoral Position in Pediatric Pain

McGill University, Montreal, Quebec, Canada

IASP 16th World Congress on Pain

September 26-30, 2016
Pacifico Convention Centre
Yokohama, Japan

Please click HERE for full details.

IASP's Global Year Against Pain in the Joints

January marks the launch of IASP's 2016 Global Year Against Pain in the Joints.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Dec 9, 2015

Impairments of the primary afferent nerves in a rat model of diabetic visceral hyposensitivity

Diabetic neuropathy in visceral organs such as the gastrointestinal (GI) tract is still poorly understood, despite that GI symptoms are among the most common diabetic complications. The present study was designed to explore the changes in visceral sensitivity and the underlying functional and morphological deficits of the sensory nerves in short-term diabetic rats.
Dec 1, 2015

Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception

Chronic stress has been reported to increase basal pain sensitivity and/or exacerbate existing persistent pain. However, most surgical patients have normal physiological and psychological health status such as normal pain perception before surgery although they do experience short-term stress during pre- and post-operative periods.
Nov 24, 2015

The role of Na <sub>v</sub> 1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia

and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG). 1.9 in the development of trigeminal neuralgia.
Nov 14, 2015

Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization

ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological block of natriuretic peptide receptor-A (NPR-A), outlining a potential inhibitory role of endogenous natriuretic peptides in nociception mediated by P2X3 receptors.
Nov 14, 2015

The effect of kinin B1 receptor on chronic itching sensitization

Altered kallikrein-related peptidase activity and bradykinin are associated with skin disorders in humans and mice under chronic inflammation conditions. The bradykinin B1 receptor (B1R), also known as one of the G-protein-coupled receptor family and usually absent in intact tissues and upregulated during tissue injury, is responsible for vasodilation, capillary permeability, nociceptor sensitization, and pain; it is indispensable for physiopathological progress in chronic inflammation conditions, but its roles and effectors in the itching sensation of the allergic contact dermatitis model are poorly defined.
Nov 13, 2015

Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration

Peripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown.