Apr 2, 2020

Ca2+-activated potassium channels modulate chronic pain-related anxiety behaviour

Anxious behaviour and anxiety disorders are common comorbidities in chronic pain patients. The anterior cingulate cortex (ACC) is an area of the brain that processes anxiety and the affective dimension (unpleasant feeling) of pain. However, within the central nervous system the molecular link of anxiety in chronic pain is unclear.
Apr 2, 2020

Functional brain changes are associated with neuropathic pain relief from ketamine treatment

Neuropathic pain is difficult to treat and significantly affects quality of life. Intravenous infusion of ketamine is a growing treatment option for patients with neuropathic pain and has been shown to provide effective and long-term pain relief. However, almost half of patients that receive this therapy do not achieve analgesic effectiveness. To explore this issue, UTCSP members Dr. Anton Rogachov, Dr. Rachael Bosma, and senior author Dr. Karen Davis, with their colleagues at the Krembil Brain Institute led a study examining brain functional activity in ketamine responders and non-responders.
Jan 31, 2020

Contrasting roles in acute and chronic pain of the growth factor, epiregulin.

Targeting the epidermal growth factor receptor (EGFR) family of proteins has proven to be analgesic in chronic pain animal models and in patients with chronic pain. Thus, in this study led by UTCSP scientist, Loren Martin, and McGill researcher, Luda Diatchenko, they aimed to determine whether there are genetic variants in EGFR-encoding genes or in genes of ligands of EGFR that correlate with chronic pain. 
Jan 31, 2020

A new clinical pain syndrome: Trigeminal neuralgia associated with a solitary pontine lesion

Trigeminal neuralgia (TN) is a facial pain disorder distinguished by extremely severe, electric shock-like attacks of pain to one side of the face. The pain is due to problems with the brain’s trigeminal nerve, which carries sensation from the face to the brain. Conventional magnetic resonance imaging of patients with TN typically does not reveal identifiable brain lesions or atrophy – essentially, their scan is completely normal. In a newly published article by UTCSP members, lead author Sarasa Tohyama with senior author Dr. Mojgan Hodaie and colleagues, identified a unique subgroup of patients with TN who present with a single, distinct lesion in the pontine region of the brainstem.
Jan 15, 2020

International research collaboration to hunt for a biological signature of chronic pain in adolescents

NIH awards $9 million to a two-phase team project with the University of Toronto, the Hospital for Sick Children, Stanford University and the Cincinnati Children’s Hospital 
An international research collaboration has been awarded a $9 million research grant from the U.S. National Institutes of Health to tackle the complex problem of chronic musculoskeletal pain in adolescents. The five-year research project, involving two distinct phases and an international team of researchers from the University of Toronto (assistant professor Massieh Moayedi), the Hospital for Sick Children, Stanford University, and Cincinnati Children’s Hospital, will work towards uncovering a biological signature for chronic pain — and help those for whom traditional therapies aren’t effective.

Click HERE for complete details.
Jan 31, 2020


Congratulations to UTCSP Members Iacopo Cioffi and Massieh Moayedi (Principal Investigators) who have been awarded $100,000 from CIHR’s Institute of Muskuloskeletal Health and Arthritis for their proposal titled Identifying a novel neuromuscular biomarker signature of chronic temporomandibular disorders
Dec 13, 2019

UTCSP Announces New Leadership

We are delighted to announce that Dr. Robert Bonin, Assistant Professor, Leslie Dan Faculty of Pharmacy and Dr. Rachael Bosma, Assistant Professor, Faculty of Dentistry, Research Lead, Toronto Academic Pain Medicine Institute have been appointed Co-Directors of the University of Toronto Centre for the Study of Pain commencing January 1, 2020 for a 5-year term.



Apply before April 30, 2020!
Toronto Summer Institute in Pain:
The Brain Behind the Pain: from Neural Encoding to the Patient Experience

July 13-17, 2020
Massey College
University of Toronto
Click HERE for program and application details


UTCSP Pain Scientist Scholarship

Applications are now being accepted
Application deadline:  Friday, July 3, 2020
Click HERE for complete details and application forms

IASP 2020 World Congress On Pain

August 4-8, 2020

For further information, please click on the LINK

IASP's Global Year for the Prevention of Pain

January marked the launch of IASP's 2020 Global Year for the Prevention of Pain. IASP sponsors and promotes the Global Year For Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Mar 25, 2020

The 8th Asian Pain Symposium (APS 2019): Summary and Abstracts

Molecular Pain, Volume 16, Issue , January-December 2020.
Mar 12, 2020

GluA1 in central amygdala increases pain but inhibits opioid withdrawal-induced aversion

Molecular Pain, Volume 16, Issue , January-December 2020.
Mar 5, 2020

Bone cancer-induced pain is associated with glutamate signalling in peripheral sensory neurons

Molecular Pain, Volume 16, Issue , January-December 2020.