Nov 15, 2016

New e-Book!

The Basic Science of Pain
An Illustrated and Clinically Oriented Guide
Philip Peng Educational Series
Nov 9, 2016

Diurnal variations in chronic pain are mediated by glucocorticoid regulation of ATP

Diurnal variations in symptoms of chronic pain patients have been widely reported. However, the underlying mechanisms for this phenonemon have yet to be delineated. UTCSP scientist Michael Salter has collaborated with scientists in Japan to help reveal the molecular mechanisms underlying diurnal variations in pain hypersensitivity.
Nov 9, 2016

Targeting adenylyl cyclase in bone cancer pain

Scientists in China have collaborated with UTCSP scientist Min Zhuo to investigate the potential mechanisms of bone cancer pain, a greatly understudied form of chronic pain. Patients with bone cancer experience severe pain at the site of the cancerous tumour, manifesting as continuous and/or spontaneous pain, and allodynia. This pain often becomes worse as the cancer progresses, greatly decreasing patient quality of life. Previous studies of other types of chronic pain have shown a role of the anterior cingulate cortex (ACC) and a compound called adenylyl cyclase (AC) in the development of the chronic pain condition. AC is activated when a neuron is very active, which triggers the production of cAMP and PKA, two second messengers involved in increased gene transcription and translation. This process works to increase glutamate receptor expression at the post-synaptic membrane, effectively potentiating synapses and increasing the fidelity of pain signals reaching the brain. In this study, the authors sought to determine whether this AC cascade in the ACC is also occurring in bone cancer pain models.
Sep 28, 2016

Variability in fMRI BOLD signal is a novel indicator of pain sensitivity and coping

Dr. Karen Davis and PhD student Anton Rogachov have recently discovered that regional blood oxygen level-dependent (BOLD) signal variability is a novel indicator of pain sensitivity and coping. Published online by PAIN in July, this study is the first to demonstrate a link between neural signal variability and an individual’s acute pain sensitivity and ability to cope with pain.
Sep 28, 2016

Connaught Summer Institute in Pain keynote lecture: Inhibition of tetrahydrobiopterin synthesis alleviates neuropathic and inflammatory pain

The Connaught Summer Institute in Pain brought pain research trainees from across the globe to Toronto to learn about the integration of research and clinical practice. The weeklong pain school culminated in a scientific meeting with keynote speaker Dr. Clifford Woolf, a renowned preclinical pain researcher based out of Boston Children's Hospital and Harvard University. Dr. Woolf discussed his recent research published in Neuron which highlighted the potential viability of targeting the tetrahydrobiopterin (BH4) synthesis pathway to treat inflammatory and neuropathic pain in humans.
May 6, 2016

Poor Pain Outcomes After Musculoskeletal Surgery Can Be Predicted By Post-Injury Anxiety and PTSD

New clinical research from UTCSP members Dr. Colin McCartney and Dr. Joel Katz, and PhD candidate Brittany Rosenbloom helps to shed light on the vulnerabilities in patients that may predispose them to have poor pain outcomes, including development of chronic neuropathic pain.
May 6, 2016

Cognitive Behavioural Training for Pain: Does it Change your Brain?

UTCSP member Dr. Karen Davis and her colleagues, Drs. Aaron Kucyi and Tim Salomons, recently reported in PAIN on differences in the brain function of healthy individuals via fMRI before and after cognitive behavioural training and repeated painful heat stimulus application.



Canadian Pain Society 38th Annual Scientific Meeting
May 23-26, 2017 - Halifax, Nova Scotia
DEADLINE:  Wednesday, November 30, 2016


UTCSP Annual Scientific Meeting
Tuesday, February 28, 2017
8:00 a.m. - 1:00 P.M.
Toronto Rehabilitation Institute
550 University Avenue
*Further details will be announced shortly


CONNAUGHT Summer Institute in Pain
University of Toronto Centre for the Study of Pain
July 17-21, 2017
Massey College, University of Toronto
Application Deadline:  February 2017

Please check back for further information as it becomes available.

Institute on Advancing Chronic Pain Assessment and Management

Lawrence S. Bloomberg Faculty of Nursing
Centre for Professional Development
April 27-28, 2017
 More Information

Canadian Pain Society 38th Annual Scientific Meeting

May 23-26, 2017
Halifax, Nova Scotia
For further information, please visit the CPS Website

IASP's Global Year Against Pain in the Joints

January marks the launch of IASP's 2016 Global Year Against Pain in the Joints.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Oct 19, 2016

MicroRNA-30b regulates expression of the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in the rat

Jinping Shao, Jing Cao, Jiannan Wang, Xiuhua Ren, Songxue Su, Ming Li, Zhihua Li, Qingzan Zhao, Weidong Zang
Oct 19, 2016; 12:174480691-174480691
Research Article
Oct 4, 2016

Transcriptome analysis of trigeminal ganglia following masseter muscle inflammation in rats

Man-Kyo Chung, Jennifer Park, Jamila Asgar, Jin Y.
Sep 9, 2016

Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model

Wen-bo Kang, Qi Yang, Yan-yan Guo, Lu Wang, Dong-sheng Wang, Qiang Cheng, Xiao-ming Li, Jun Tang, Jian-ning Zhao, Gang Liu, Min Zhuo, Ming-gao Zhao
Sep 9, 2016; 12:174480691-174480691
Research Article
Sep 5, 2016

Downregulation of miR-219 enhances brain-derived neurotrophic factor production in mouse dorsal root ganglia to mediate morphine analgesic tolerance by upregulating CaMKII{gamma}

Xue-Ming Hu, Shou-Bin Cao, Hai-Long Zhang, Dong-Mei Lyu, Li-Ping Chen, Heng Xu, Zhi-Qiang Pan, Wen Shen
Sep 5, 2016; 12:174480691-174480691
Research Article
Sep 2, 2016

BDNF signaling contributes to oral cancer pain in a preclinical orthotopic rodent model

Leah Chodroff, Michelle Bendele, Vanessa Valenzuela, Michael Henry, Shivani Ruparel
Sep 2, 2016; 12:174480691-174480691
Research Article
Sep 2, 2016

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-{alpha} up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opioid receptors-mediated antiallodinic effect

Nunzio Vicario, Rosalba Parenti, Giuseppina Arico, Rita Turnaturi, Giovanna Maria Scoto, Santina Chiechio, Carmela Parenti
Sep 2, 2016; 12:174480691-174480691
Short Report