Apr 27, 2015

An end to cancer pain?

A new study led by University of Toronto researcher Dr. David Lam has discovered the trigger behind the most severe forms of cancer pain.
Apr 14, 2015

Announcement: Dr. Mike Salter appointed Chief of Research at the Hospital for Sick Children

Dr. Mike Apok, President and CEO at the Hospital for Sick Children announces the appointment of Dr. Michael Salter to the position of Chief of Research:


Call for Applications

2015/16 UTCSP Pain Scientist Scholarship
Application Deadline:  July 15, 2015
For complete Award details and application forms, please click on the following LINK

Molecular Structure and Function Program Seminar Series

Prof. Yifan Cheng, Department of Biochemistry and Biophysics, University of California San Francisco will present "Structure of TRP channels by single particle cryo-EM: from blobology to atomic structures"  

Monday, May 25, 2015
1:00 p.m. - 2:00 p.m.
Room 02.9320, Event Room 1, PGCRL,  686 Bay Street  

Host:  Dr. John Rubinstein 
Pizza Lunch will be provided  

Pain Management: The Role of Opioids, Addiction Medicine and "End of Life" Decisions

12th Annual Pain Day Event - Queen's University
June 18, 2015

This is a multidisciplinary conference featuring leading experts in chronic pain management
For program details and to register, please click on the LINK
Click HERE for a registration form

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

May 12, 2015

Current gene therapy using viral vectors for chronic pain

The complexity of chronic pain and the challenges of pharmacotherapy highlight the importance of development of new approaches to pain management. Gene therapy approaches may be complementary to pharmacotherapy for several advantages.
May 9, 2015

Sodium channel Na<sub>V</sub>1.7 in vascular myocytes, endothelium, and innervating axons in human skin

The skin is a morphologically complex organ that serves multiple complementary functions, including an important role in thermoregulation, which is mediated by a rich vasculature that is innervated by sympathetic and sensory endings. Two autosomal dominant disorders characterized by episodes of severe pain, inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD) have been directly linked to mutations that enhance the function of sodium channel NaV1.7.
May 2, 2015

Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice

It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain.
May 2, 2015

Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons

Hydrogen sulfide (H2S) is oxidized to polysulfide. Recent reports show that this sulfur compound modulates various biological functions.
Apr 24, 2015

<it>In situ</it> patch-clamp recordings from Merkel cells in rat whisker hair follicles, an experimental protocol for studying tactile transduction in tactile-end organs

Mammals use tactile end-organs to perform sensory tasks such as environmental exploration, social interaction, and tactile discrimination. However, cellular and molecular mechanisms underlying tactile transduction in tactile end-organs remain poorly understood.
Apr 21, 2015

Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin

The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches.