UTCSP News

Nov 15, 2016

New e-Book!

The Basic Science of Pain
An Illustrated and Clinically Oriented Guide
Philip Peng Educational Series
Nov 9, 2016

Diurnal variations in chronic pain are mediated by glucocorticoid regulation of ATP

Diurnal variations in symptoms of chronic pain patients have been widely reported. However, the underlying mechanisms for this phenonemon have yet to be delineated. UTCSP scientist Michael Salter has collaborated with scientists in Japan to help reveal the molecular mechanisms underlying diurnal variations in pain hypersensitivity.
Nov 9, 2016

Targeting adenylyl cyclase in bone cancer pain

Scientists in China have collaborated with UTCSP scientist Min Zhuo to investigate the potential mechanisms of bone cancer pain, a greatly understudied form of chronic pain. Patients with bone cancer experience severe pain at the site of the cancerous tumour, manifesting as continuous and/or spontaneous pain, and allodynia. This pain often becomes worse as the cancer progresses, greatly decreasing patient quality of life. Previous studies of other types of chronic pain have shown a role of the anterior cingulate cortex (ACC) and a compound called adenylyl cyclase (AC) in the development of the chronic pain condition. AC is activated when a neuron is very active, which triggers the production of cAMP and PKA, two second messengers involved in increased gene transcription and translation. This process works to increase glutamate receptor expression at the post-synaptic membrane, effectively potentiating synapses and increasing the fidelity of pain signals reaching the brain. In this study, the authors sought to determine whether this AC cascade in the ACC is also occurring in bone cancer pain models.
Sep 28, 2016

Variability in fMRI BOLD signal is a novel indicator of pain sensitivity and coping

Dr. Karen Davis and PhD student Anton Rogachov have recently discovered that regional blood oxygen level-dependent (BOLD) signal variability is a novel indicator of pain sensitivity and coping. Published online by PAIN in July, this study is the first to demonstrate a link between neural signal variability and an individual’s acute pain sensitivity and ability to cope with pain.
Sep 28, 2016

Connaught Summer Institute in Pain keynote lecture: Inhibition of tetrahydrobiopterin synthesis alleviates neuropathic and inflammatory pain

The Connaught Summer Institute in Pain brought pain research trainees from across the globe to Toronto to learn about the integration of research and clinical practice. The weeklong pain school culminated in a scientific meeting with keynote speaker Dr. Clifford Woolf, a renowned preclinical pain researcher based out of Boston Children's Hospital and Harvard University. Dr. Woolf discussed his recent research published in Neuron which highlighted the potential viability of targeting the tetrahydrobiopterin (BH4) synthesis pathway to treat inflammatory and neuropathic pain in humans.
May 6, 2016

Poor Pain Outcomes After Musculoskeletal Surgery Can Be Predicted By Post-Injury Anxiety and PTSD

New clinical research from UTCSP members Dr. Colin McCartney and Dr. Joel Katz, and PhD candidate Brittany Rosenbloom helps to shed light on the vulnerabilities in patients that may predispose them to have poor pain outcomes, including development of chronic neuropathic pain.
May 6, 2016

Cognitive Behavioural Training for Pain: Does it Change your Brain?

UTCSP member Dr. Karen Davis and her colleagues, Drs. Aaron Kucyi and Tim Salomons, recently reported in PAIN on differences in the brain function of healthy individuals via fMRI before and after cognitive behavioural training and repeated painful heat stimulus application.

Events

2017 UTCSP Annual Scientific Meeting

Tuesday, February 28, 2017
0830 to 1245
Toronto Rehabilitation Institute
Auditorium
550 University Avenue

2017/18 Purdue Pharma QEII-GSST Award

Applications are now being accepted
Deadline:  March 31, 2017
For complete award details and application forms, please click on the following LINK

STAY TUNED!

CONNAUGHT Summer Institute in Pain
University of Toronto Centre for the Study of Pain
July 17-21, 2017
Massey College, University of Toronto

Please check back for further information as it becomes available.

Institute on Advancing Chronic Pain Assessment and Management

Lawrence S. Bloomberg Faculty of Nursing
Centre for Professional Development
April 27-28, 2017
DEADLINE TO REGISTER: March 31, 2017
 More Information

Canadian Pain Society 38th Annual Scientific Meeting

May 23-26, 2017
Halifax, Nova Scotia
For further information, please visit the CPS Website

IASP's Global Year Against Pain in the Joints

January marks the launch of IASP's 2017 Global Year Against Pain After Surgery.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Nov 15, 2016

A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain

Thomas J Schnitzer, Souraya Torbey, Kristi Herrmann, Gagan Kaushal, Renita Yeasted, A Vania Apkarian
Nov 15, 2016; 12:174480691-174480691
Research Article
Nov 15, 2016

Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain

Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cuie Lu, Hui Rong, Yue Sun, Wei Zhang, Zhengliang Ma, Xiaoping Gu
Nov 15, 2016; 12:174480691-174480691
Research Article
Nov 15, 2016

Spinal astrocytic activation contributes to mechanical allodynia in a rat model of cyclophosphamide-induced cystitis

Bolong Liu, Minzhi Su, ShaoJun Tang, Xiangfu Zhou, Hailun Zhan, Fei Yang, Wenbiao Li, Tengcheng Li, Juncong Xie
Nov 15, 2016; 12:174480691-174480691
Research Article
Nov 11, 2016

Differential contributions of vasopressin V1A and oxytocin receptors in the amygdala to pain-related behaviors in rats

Bryce Cragg, Guangchen Ji, Volker Neugebauer
Nov 11, 2016; 12:174480691-174480691
Short Report
Nov 11, 2016

Preventing painful age-related bone fractures: Anti-sclerostin therapy builds cortical bone and increases the proliferation of osteogenic cells in the periosteum of the geriatric mouse femur

Michelle L Thompson, Stephane R Chartier, Stefanie A Mitchell, Patrick W Mantyh
Nov 11, 2016; 12:174480691-174480691
Research Article
Nov 7, 2016

A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels

Harshvardhan Rolyan, Shujun Liu, Janneke GJ Hoeijmakers, Catharina G Faber, Ingemar SJ Merkies, Giuseppe Lauria, Joel A Black, Stephen G Waxman
Nov 7, 2016; 12:174480691-174480691
Research Article