UTCSP News

May 27, 2019

Gabapentin upregulates GABAA receptor δ subunit – a novel mechanism of action

Gabapentin (also known as Neurontin) is clinically prescribed for the treatment of seizures, pain, and anxiety. While gabapentin is known to modulate voltage-gated calcium channels, some studies have suggested the effects of gabapentin are also dependent on GABAergic inhibition. However, gabapentin neither binds GABA receptors nor increases GABA release, thus its precise mechanisms of action remain unclear and is what UTCSP scientists, Dr. Beverly Orser, Dr. Robert Bonin, and collaborators, aimed to uncover.
May 27, 2019

Highlights from the 2019 UTCSP Scientific Meeting

On February 28th, the UTCSP held its Annual Scientific Meeting at the Chestnut Conference Centre. This year’s theme was “Global Year in Pain: Pain in the Most Vulnerable”. After a welcome and introduction by Drs. Rob Bonin and Massieh Moayedi, attendees had the opportunity to hear from several speakers, including UTCSP faculty and trainees with expertise in both basic and clinical pain research.
 
Feb 28, 2019

Large-scale data analysis of pain volatility from users of the “Manage My Pain” app

The advent of technology and mobile health apps has transformed the way people monitor, manage, and communicate health-related information. For pain, “Manage My Pain” is a mobile health app used by thousands of individuals to measure and manage their pain. It also has the capacity for large-scale, real-world data collection to advance pain research, treatment, and policy. In particular, data mining and machine learning methods can be used to analyze multimodal and dynamic features as well as build models for prediction. This may ultimately help us understand how pain changes across time within users and to allow for the development of effective coping strategies. 
Feb 28, 2019

Conditioned pain modulation is not unidirectional: both hyper- and hypoalgesia can arise depending on the stimulus

The advent of technology and mobile health apps has transformed the way people monitor, manage, and communicate health-related information. For pain, “Manage My Pain” is a mobile health app used by thousands of individuals to measure and manage their pain. It also has the capacity for large-scale, real-world data collection to advance pain research, treatment, and policy. In particular, data mining and machine learning methods can be used to analyze multimodal and dynamic features as well as build models for prediction. This may ultimately help us understand how pain changes across time within users and to allow for the development of effective coping strategies. 
Dec 19, 2018

Diffusion tensor imaging as a clinically translatable prognostication tool for neurosurgery

Outcomes of neurosurgical treatments for chronic pain are typically evaluated using clinical diagnostic measures. These measures, while important, are limited because they do not provide objective information about treatment effects nor offer any prognostic value. Advanced modalities of imaging may be used as a tool to monitor the effects of treatment and predict whether patients will achieve long-term pain relief.
Dec 19, 2018

Sexual dimorphism in pain hypersensitivity mechanisms is conserved across rodent species

Sex differences in the role of spinal microglia, immune cells of the central nervous system, in pain signalling have only recently been discovered using mouse models. Now, in this study conducted by UTCSP scientists in Dr. Michael Salter’s group and collaborators, they showed that this sex difference is conserved across species by examining rats. Rats are an excellent species to test if sex differences in microglia involvement of chronic pain are conserved because certain immune responses and immune-related genes differ between mice and rats.
Oct 25, 2018

Microglial pannexin-1 as a target for joint pain

Arthritis is a debilitating condition that causes chronic joint pain. While the pathology of arthritis is characterized by peripheral joint inflammation, the associated pain arises from activation of nociceptive circuits from the periphery that converge in the spinal cord. Since such activity can lead to central sensitization through activation of microglia, a central nervous system-resident immune cell, it is possible that microglia drive joint pain.

Events

UTCSP Pain Scientist Scholarship

Applications are now being accepted
Application deadline:  Friday, July 5, 2019
For complete Award details and application forms, please click on the LINK

Canadian Pain Society 41st Annual Scientific Meeting

May 19-22, 2020
Hyatt Regency Calgary
Calgary, Alberta

For further information, please click on the LINK

IASP 2020 World Congress On Pain

Amsterdam
August 4-8, 2020

For further information, please click on the LINK

IASP's Global Year For Excellence In Pain Education

January marks the launch of IASP's 2018 Global Year For Excellence In Pain Education.  IASP sponsors and promotes the Global Year For Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website