May 6, 2016

Poor Pain Outcomes After Musculoskeletal Surgery Can Be Predicted By Post-Injury Anxiety and PTSD

New clinical research from UTCSP members Dr. Colin McCartney and Dr. Joel Katz, and PhD candidate Brittany Rosenbloom helps to shed light on the vulnerabilities in patients that may predispose them to have poor pain outcomes, including development of chronic neuropathic pain.
May 6, 2016

Cognitive Behavioural Training for Pain: Does it Change your Brain?

UTCSP member Dr. Karen Davis and her colleagues, Drs. Aaron Kucyi and Tim Salomons, recently reported in PAIN on differences in the brain function of healthy individuals via fMRI before and after cognitive behavioural training and repeated painful heat stimulus application.
May 5, 2016


Congratulations to Dr. Ze'ev Seltzer who was recently awarded an Honorary Professorship at the University of Heidelberg, Germany.
Mar 16, 2016

Neural Mechanisms Underlying Anxiety-Chronic Pain Interactions

In a recent article in Trends in Neuroscience, Dr. Min Zhuo discusses the link between anxiety and chronic pain. While chronic pain and anxiety are often comorbid, and treating anxiety can result in a reduction in pain, these conditions are usually studied separately. Dr. Zhuo proposes that these conditions are related via long-term potentiation (LTP) mechanisms in the anterior cingulate cortex (ACC).
Mar 16, 2016

The Periaqueductal Gray Matter: Sub-regions and Functional Connectivity with Descending Pain Modulation Circuitry

The experience of pain is highly variable between individuals for a multitude of physiological and psychological reasons. Evidence now suggests that part of this variability is due to interactions between ascending nociceptive signaling pathways and descending modulatory circuitry. The periaqueductal gray matter (PAG) is a critical brain region involved in top-down modulatory circuits. The laboratory of Dr. Karen Davis, and post-doctoral fellow Dr. Marie-Andree Colulombe recently investigated sub-regions of the PAG and their functional connectivity with other brain regions involved in pain processing.
Jan 20, 2016

Longitudinal Study of Catastrophizing, Pain and Cortical Thickness in Chronic Pain Patients

Neuropathic pain is a common chronic pain condition, which occurs following peripheral nerve injury (PNI). It is currently unknown why only some individuals with PNI develop chronic pain. However, it is predicted that both biological and psychological factors contribute to this process. The laboratory of Dr. Karen Davis recently conducted a longitudinal investigation of pan catastrophizing (i.e., when an individual has exaggerated negative thinking about painful experiences) and insula gray matter changes in patients with nerve injury.
Jan 20, 2016

Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms

Kasey Hemington, Keith Wu, Aaron Kucyi, Robert Inman and Karen Davis recently published a neuroimaging study, characterizing abnormalities between functional brain networks in chronic pain patients. The authors used resting state, functional magnetic resonance imaging to uncover abnormal connections between functional networks that were closely related to clinical symptom severity.


UTCSP Trainee Welcome Event

Tuesday, September 13, 2016
4:30 p.m. to 6:00 p.m.
155 College Street, Room 124, Main Floor

Light food and refreshments will be served



UTCSP Annual Scientific Meeting
Tuesday, February 28, 2017
8:00 a.m. to 1:00 p.m.
Toronto Rehabilitation Institute
550 University Avenue
*Further details will be announced shortly

IASP 16th World Congress on Pain

September 26-30, 2016
Pacifico Convention Centre
Yokohama, Japan

Please click HERE for full details.

IASP's Global Year Against Pain in the Joints

January marks the launch of IASP's 2016 Global Year Against Pain in the Joints.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Jul 12, 2016

Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury

Dustin P Green, Shivani Ruparel, Xiaoli Gao, Nikita Ruparel, Mayur Patil, Armen Akopian, Kenneth M Hargreaves
Jul 12, 2016; 12:174480691-174480691
Research Article
Jul 5, 2016

Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats

Dong-Yuan Cao, Guang Bai, Yaping Ji, Jane Karpowicz, Richard J Traub
Jul 5, 2016; 12:174480691-174480691
Research Article
Jul 5, 2016

F-actin links Epac-PKC signaling to purinergic P2X3 receptor sensitization in dorsal root ganglia following inflammation

Yanping Gu, Congying Wang, GuangWen Li, Li-Yen M Huang
Jul 5, 2016; 12:174480691-174480691
Research Article
Jul 5, 2016

Voltage-dependent sodium (NaV) channels in group IV sensory afferents

Renuka Ramachandra, Keith S Elmslie
Jul 5, 2016; 12:174480691-174480691
Research Article
Jun 20, 2016

Novel CLCN7 mutation identified in a Han Chinese family with autosomal dominant osteopetrosis-2

Hao Deng, Dan He, Pengfei Rong, Hongbo Xu, Lamei Yuan, Liu Li, Qian Lu, Yi Guo
Jun 20, 2016; 12:174480691-174480691
Research Article
Jun 20, 2016

Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer

U Anand, M Sinisi, M Fox, A MacQuillan, T Quick, Y Korchev, C Bountra, T McCarthy, P Anand
Jun 20, 2016; 12:174480691-174480691
Research Article