Jun 8, 2015

WHO Backs U of T Professor's Recommendations For Reducing Pain Of Vaccines

Apr 27, 2015

An end to cancer pain?

A new study led by University of Toronto researcher Dr. David Lam has discovered the trigger behind the most severe forms of cancer pain.
Apr 14, 2015

Announcement: Dr. Mike Salter appointed Chief of Research at the Hospital for Sick Children

Dr. Mike Apok, President and CEO at the Hospital for Sick Children announces the appointment of Dr. Michael Salter to the position of Chief of Research:


Mark Your Calendars!

UTCSP Trainee Welcome Event
Tuesday, September 22, 2015
4:30 p.m. to 6:00 p.m.
155 College Street, Room 208, 2nd Floor

Pain Interprofessional Curriculum Design (PICD) Workshop

sponsored by the University of Toronto Centre for the Study of Pain
in association with the Centre for Interprofessional Education
October 28-30, 2015
For program details and to register, please click HERE

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

Jul 17, 2015

Identification of lncRNA expression profile in the spinal cord of mice following spinal nerve ligation-induced neuropathic pain

Neuropathic pain that caused by lesion or dysfunction of the nervous system is associated with gene expression changes in the sensory pathway. Long noncoding RNAs (lncRNAs) have been reported to be able to regulate gene expression.
Jul 15, 2015

Distribution of raphespinal fibers in the mouse spinal cord

Serotonergic raphespinal neurons and their fibers have been mapped in large mammals, but the non-serotonergic ones have not been studied, especially in the mouse. The present study aimed to investigate the termination pattern of fibers arising from the hindbrain raphe and reticular nuclei which also have serotonergic neurons by injecting the anterograde tracer BDA into them.
Jul 1, 2015

Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats

Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies suggest that CaCCs family members bestrophin-1 and anoctamin-1 are involved in inflammatory pain.
Jun 29, 2015

Temporal dynamics of anxiety phenotypes in a dental pulp injury model

Accumulating clinical and preclinical evidence indicates that chronic pain is often comorbid with persistent low mood and anxiety. However, the mechanisms underlying pain-induced anxiety, such as its causality, temporal progression, and relevant neural networks are poorly understood, impeding the development of efficacious therapeutic approaches.
Jun 26, 2015

Expression changes of microRNA-1 and its targets Connexin 43 and brain-derived neurotrophic factor in the peripheral nervous system of chronic neuropathic rats

MicroRNAs (miRNAs) are involved in the neuroplastic changes which induce and maintain neuropathic pain. However, it is unknown whether nerve injury leads to altered miRNA expression and modulation of pain relevant target gene expression within peripheral nerves.
Jun 26, 2015

Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT <sub>2</sub> R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies

R antagonist EMA401, a novel peripherally-restricted analgesic, was reported recently in post-herpetic neuralgia. R is expressed by nociceptors in human DRG (hDRG), and that EMA401 inhibits capsaicin responses in cultured hDRG neurons, the expression and levels of its endogenous ligands AngII and AngIII in clinical neuropathic pain tissues, and their signalling pathways, require investigation.