UTCSP News

Apr 14, 2015

Announcement: Dr. Mike Salter appointed Chief of Research at the Hospital for Sick Children

Dr. Mike Apok, President and CEO at the Hospital for Sick Children announces the appointment of Dr. Michael Salter to the position of Chief of Research:
Nov 21, 2014

Toronto General Hospital program uses new methods to prevent pain killer addictions after surgery

Acupuncture, exercise, psychological techniques and non-opioid pain medications used to prevent patients from developing chronic pain.
Nov 19, 2014

Congratulations Dr. Bonnie Stevens!

Congratulations to Dr. Bonnie Stevens for her most recent achievement. On November 17 she was awarded the 2014 CIHR Knowledge Translation Award. She received her award at the Innovating Child and Family Health Conference sponsored by CIHR and IHDCYH in Ottawa.

Events

Canadian Pain Society 36th Annual Scientific Meeting

May 20-23, 2015
The Delta Prince Edward Hotel
Charlottetown, Prince Edward Island
For more information and to register, please click on the LINK

Pain Management: The Role of Opioids, Addiction Medicine and "End of Life" Decisions

12th Annual Pain Day Event - Queen's University
June 18, 2015

This is a multidisciplinary conference featuring leading experts in chronic pain management
For program details and to register, please click on the LINK
Click HERE for a registration form

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

Apr 9, 2015

Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain

Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies had suggested that aberrant axon sprouting from touch sensory afferents into pain-processing laminae after injury is a possible anatomical substrate underlying mechanical allodynia.
Mar 28, 2015

Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons

Superficial dorsal horn (SDH) neurons process nociceptive information and their excitability is partly determined by the properties of voltage-gated sodium channels. Recently, we showed the excitability and action potential properties of mouse SDH neurons change markedly during early postnatal development.
Mar 26, 2015

Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain

The activation of Translocator protein (18 kDa) (TSPO) has been demonstrated to mediate rapid anxiolytic efficacy in stress response and stress-related disorders. This protein is involved in the synthesis of endogenous neurosteroids that promote γ-aminobutyric acid (GABA)-mediated neurotransmission in the central neural system.
Mar 20, 2015

Sensitization of P2X3 receptors by cystathionine <it>&#946;</it>-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation

Lumbar disc herniation (LDH) is a major cause of discogenic low back pain and sciatica, but the underlying mechanisms remain largely unknown. Hydrogen sulfide (H2S) is becoming recognized for its involvement in a wide variety of processes including inflammation and nociception.
Mar 20, 2015

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of mGlu2/3 receptors by activating the glial glutamate:cystine membrane exchanger.
Mar 17, 2015

Protease-activated receptors in the Achilles tendon&#8211;a potential explanation for the excessive pain signalling in tendinopathy

Background/AimTendinopathies are pathological conditions of tissue remodelling occurring in the major tendons of the body, accompanied by excessive nociceptive signalling. Tendinopathies have been shown to exhibit an increase in the number of mast cells, which are capable of releasing histamine, tryptase and other substances upon activation, which may play a role in the development of tendinopathies.