Nov 19, 2015

Efficacy of celecoxib in the treatment of chronic nonspecific low back pain

Dr. Robert D. Inman’s research group has demonstrated that celecoxib, a non-steroidal anti-inflammatory drug, which selectively inhibits COX-2, has superior efficacy as compared to acetaminophen in treating chronic nonspecific low back pain. Dr. Inman conducted a randomized controlled trial to compare the effects of a 4-week treatment of either celecoxib (200mg, 2x daily) or acetaminophen (500mg, 2x daily) on both pain scores and MRI scores in 50 patients with nonspecific low back pain. Patients receiving celecoxib had more relief of total back pain and nocturnal back pain as well as more significant improvements on disability measures and global assessment measures than patients receiving acetaminophen. Neither celecoxib nor acetaminophen treatment produced any changes on MRI scores of inflammatory lesions nor morning stiffness, suggesting that both treatments are only effective at reducing pain scores.
Nov 23, 2015

Preventing chronic post-surgical pain through the Toronto General Hospital Transitional Pain Service

Chronic postsurgical pain can develop in 5-10% of patients within a year of surgery. Chronic post-surgical pain is difficult to treat, and results in poor patient outcomes, including loss of work, increased medical leave, and loss of quality of life. The global annual cost of chronic post-surgical pain has been estimated in the billions of dollars, underscoring the need for better treatment for post-surgical pain.
Sep 18, 2015

Different Mechanisms of Spinal Cord Neuron Disinhibition in Neuropathic Pain Models Require Different Therapeutic Interventions

Exciting new research from Dr. Steven Prescott’s lab is working to bridge the gap between basic research on neuropathic pain etiology to possible clinical interventions to treat neuropathic pain. Dr. Steven Prescott is a UTCSP member and scientist at the Hospital for Sick Children. In this paper, lead author Dr. Kwan Lee uses a unique method to measure intact spinal cord neurons from alive, anaesthetized animals, overcoming disadvantages of ex-vivo methodologies.
Sep 18, 2015

A New Method to Detect Dishonesty in Self-Report Measures of Pain

Self-report is the most valid and frequently used measure of pain in both clinical and research settings. However, some individuals may be inclined to provide deceitful self-reports in certain situations (e.g. insurance fraud). Thus, it is desirable to have a reliable method to detect dishonesty in self-report. Recently, UTCSP alumni Dr. Aaron Kucyi demonstrated that the use of sensory interference during self-report may be a potential tool to identify feigned self-reports.
Aug 14, 2015

Inhibiting the pain trajectory with a fresh approach to perioperative care

Jul 20, 2015

Sex Differences In The Spinal Mechanisms Mediating Neuropathic Pain -- Implications Ror Pre-clinical Research

In a recently published article in Nature Neuroscience, the laboratory of Dr. Michael Salter and UTCSP trainee member Josiane Mapplebeck reported that female and male mice use different mechanisms in the mediation of neuropathic pain. Previous research has shown that microglia, a type of cell involved in neuroinflammatory processes, mediate pain hypersensitivity resulting from nerve injury. However, evidence for the role of microglia in neuropathic pain is based on pre-clinical research conducted predominantly using male rodents.  Consequently, Dr. Salter, in collaboration with Dr. Jeffrey Mogil at McGill University, investigated the spinal mechanisms mediating neuropathic pain in females. 


Call for Absracts!

Canadian Pain Society Annual Scientific Meeting
May 24-27, 2016, Vancouver, BC

Save the Date!

UTCSP Annual Scientific Meeting
Tuesday, February 9, 2016
8:00 a.m. to 1:00 p.m.
Toronto Rehabilitation Institute
550 University Avenue

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

Nov 14, 2015

Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization

ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological block of natriuretic peptide receptor-A (NPR-A), outlining a potential inhibitory role of endogenous natriuretic peptides in nociception mediated by P2X3 receptors.
Nov 14, 2015

The effect of kinin B1 receptor on chronic itching sensitization

Altered kallikrein-related peptidase activity and bradykinin are associated with skin disorders in humans and mice under chronic inflammation conditions. The bradykinin B1 receptor (B1R), also known as one of the G-protein-coupled receptor family and usually absent in intact tissues and upregulated during tissue injury, is responsible for vasodilation, capillary permeability, nociceptor sensitization, and pain; it is indispensable for physiopathological progress in chronic inflammation conditions, but its roles and effectors in the itching sensation of the allergic contact dermatitis model are poorly defined.
Nov 13, 2015

Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration

Peripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown.
Nov 5, 2015

p38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons

We have previously shown that endogenously active purinergic P2X7 receptors (P2X7Rs) in satellite glial cells of dorsal root ganglia (DRGs) stimulate ATP release. The ATP activates P2Y1Rs located in the enwrapped neuronal somata, resulting in down-regulation of P2X3Rs.
Oct 28, 2015

The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients

Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA).
Oct 23, 2015

MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences

Molecular mediators influencing the transition from acute to persistent musculoskeletal pain following common stress exposures such as motor vehicle collision (MVC) remain poorly understood. In this exploratory, proof of concept study, we compared circulating microRNA (miRNA) expression profiles in the early aftermath of MVC among individuals who did and did not subsequently develop persistent pain.