Jul 24, 2014

A Tipping Point for Neuropathic Pain Research

Finding new treatments for neuropathic pain has thus far proved to be incredibly difficult. Many newly developed treatments in animal models have proved ineffective when translated to humans, or failed due to undesirable side effects. Dr. Stephanie Ratte from Steven Prescott’s Lab at the Hospital for Sick Children proposes in novel research why this may be the case.
Jul 29, 2014

Mark Your Calendars!

UTCSP Trainee Meet & Greet Event
Tuesday, September 23, 2014
4:30 p.m . to 6:30 p.m.
Room 208, 155 College Street
Health Sciencies Building, U of T

Graduate students interested in and/or conducting research in the area of pain are invited to learn about the UTCSP and meet some of its members at this informal event.  Further details will be announced shortly.
Jul 29, 2014


Congratulations to Dr. Jennifer Stinson, nurse clinician scientist in the Child Health Evaluative Sciences program in the SickKids Research Institute and Nurse Practitioner with the Chronic Pain Service in the Department of Anaesthesia and Pain Medicine, as inaugural holder of the
Mary Jo Haddad Chair in Child Health on July 1, 2014.   In partnership with the Lawrence S. Bloomberg Faculty of Nursing, this Chair will create opportunities to advance pediatric nursing and generate knowledge through research that will ultimately improve current day practices and outcomes for children and adolescents
Jul 17, 2014

TEDTalk: How does your brain respond to pain?

Everyone experiences pain -- but why do some people react to the same painful stimulus in different ways? And what exactly is pain, anyway? Karen D. Davis walks you through your brain on pain, illuminating why the “pain experience” differs from person to person.
May 1, 2014

UTCSP Members Make Toronto Life's Top 30 List of Best Doctors in Toronto!

Congratulations to Allan Gordon (Pain Medicine) and John Flannery (Physiatry) for being recognized by Toronto Life Magazine as being the best in your field.
May 1, 2014

Better Care for Patients with Chronic Pain

Ontario giving health care providers more tools to help chronic pain patients. Ontario is improving care for patients suffering from chronic pain with new initiatives to ensure they receive appropriate treatment, diagnostic testing and medication. The province is working with the University Health Network on two intiatives that will help primary care providers care for chronic pain sufferers. 


UTCSP Trainee Welcome Event

Tuesday, September 23, 2014
4:30 p.m. to 6:00 p.m.
155 College Street, Room 208, 2nd Floor
U of T Health Sciences Building

*Light food and refreshments will be served

UTCSP Strategic Planning Session

Monday, November 3, 2014
12:00 noon to 5:00 p.m.
89 Chestnut Street Conference Centre

*Lunch will be served from 12:00 - 1:00
Pain Interprofessional Curriculum Design


Pain Interprofessional Curriculum Design (PICD) Workshop
hosted by the University of Toronto Centre for the Study of Pain
in association with the University of Toronto Centre for Interprofessional Education
November 12-14, 2014

National Jeans Day for Pain

Thursday, November 6, 2014
Sponsored by the Canadian Pain Coalition

For further details please click on the LINK

15th World Congress on Pain

Presented by the International Association for the Study of Pain (IASP)
October 6 - 11, 2014
Buenos Aires

For further details, please visit the IASP website by clicking on the following LINK

Global Year Against Orofacial Pain - October 2013 - October 2014

For More Information

UTCSP Annual Scientific Meeting 2015

co-sponsored with the Hospital for Sick Children's Pain Centre
Tuesday, February 10, 2015
8:00 a.m. to 1:30 p.m.
Peter Gilgan Centre for Research & Learning
Classroom 2a,b and Gallery, 686 Bay Street
The Hospital for Sick Children

How to Navigate Difficult Medical Conditions

11th Annual Pain Day Event
This is a multidisciplinary conference featuring leading experts in chronic pain
June 20, 2014
Delta Waterfront Hotel
Kingston, Ontario

For complete details and to register, click on the following LINK


Keystone Symposia on Molecular and Cellular Biology

The Brain: Adaptation and Maladaptation in Chronic Pain
June 15-20, 2014

Keystone Resort, Keystone, Colorado, USA
For more information regarding registration, important deadlines, and to view the full program, please follow the LINK

Pain in the News

Aug 14, 2014

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy.
Aug 14, 2014

Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord.

Three neuropeptides, gastrin releasing peptide (GRP), natriuritic precursor peptide B (NPPB), and neuromedin B (NMB) have been proposed to play roles in itch sensation. However, the tissues in which these peptides are expressed and their positions in the itch circuit has recently become the subject of debate.
Aug 13, 2014

Cyclic phosphatidic acid relieves osteoarthritis symptoms

Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. Natural cPA and its chemically stabilized cPA derivative, 2-carba-cPA (2ccPA), inhibit chronic and acute inflammation, and 2ccPA attenuates neuropathic pain.
Aug 12, 2014

Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain

The analgesic potency of opioids is reduced in neuropathic pain. However, the molecular mechanism is not well understood.
Jul 31, 2014

ß-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons

Despite advances in understanding the signaling mechanisms involved in the development and maintenance of chronic pain, the pharmacologic treatment of chronic pain has seen little advancement. Agonists at the mu opioid receptor (MOPr) continue to be vital in the treatment of many forms of chronic pain, but side-effects limit their clinical utility and range from relatively mild, such as constipation, to major, such as addiction and dependence.
Jul 29, 2014

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

HIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active antiretroviral therapy (HAART). Evidence shows that painful HIV sensory neuropathy is influenced by neuroinflammatory events that include the proinflammatory molecules, MAP Kinase, tumor necrosis factor-α (TNFα), stromal cell-derived factor 1-α (SDF1α), and C-X-C chemokine receptor type 4 (CXCR4).