Jan 10, 2021

Myofascial Pain Syndrome is Associated with Lower Insulin-Like Growth Factor-2 Levels

Myofascial pain syndrome (MPS) is a musculoskeletal chronic pain disorder with pathological contraction of localized muscle fibers, resulting in local and referred pain. MPS is often caused by muscle injury or damage. Insulin-like growth factors, IGF-1 and IGF-2, are hormones that regulate muscle growth, differentiation, as well as muscle maintenance and repair. Pain resulting from MPS is thought to be due to biochemical changes at peripheral nociceptive neurons and IGF-1 has also been implicated in the nociceptive pathway. However, the role of IGF-2 has yet to be implicated in pain and whether IGFs contribute to MPS specifically have not been extensively investigated.
Dec 14, 2020

Inpatient stay duration after joint replacement is associated with pain intensity and opioid use

Knee and hip replacements are high volume, costly procedures and the need for these surgeries are on the rise in Canada. About 10% of elective joint replacement patients are recommended to be sent to inpatient rehabilitation. However, the factors that contribute to longer stays for patients have not been previously investigated. UTCSP scientist Dr. Andrea Furlan and colleagues hypothesized that patients with better pain improvement and less opioid consumption during the initial few post-surgical days will have overall shorter rehabilitation stays.
Nov 16, 2020

Caring for pain patients during the pandemic

Chronic pain affects as much as 11.2% of the adult population according to the United States 2012 National Health Interview survey, making it the most common co-existing condition. With the world pandemic due to COVID-19, healthcare systems across the world have had to postpone or cancel all elective procedures, and care for patients with chronic pain has taken a back seat in some instances. In response to the urgent need for guidelines for the management of chronic pain patients during the current world pandemic, UTCSP scientist Dr. Anuj Bhatia, along with other expert healthcare providers and pain researchers, came together to formulate practice recommendations to help physicians and health providers continue to care for their patients with chronic pain.
Oct 18, 2020

Chronic pain changes in functional network organization of the brain in a sex-specific manner

Although brain structures largely overlap between the sexes, there are specific morphological and functional brain differences between males and females. These differences may contribute to the observed differences in pain perception between men and women. For example, women are more sensitive to noxious stimuli compared to men, but exhibit greater habituation to repeated or sustained noxious stimuli. Recent reports have also found that sex differences in pain sensitivity is related to resting state functional connectivity within the dynamic pain connectome – the neural networks involved in pain processing. Despite understanding individual brain networks related to pain and sex differences in pain sensitivity, the interaction and communication between the different individual brain networks has not been studied.
Sep 16, 2020

Media reporting strategies surrounding opioid usage can shape public opinion

The amount of media coverage surrounding opioid consumption has dramatically increased since the turn of the century. Since popular media has a major impact on public perceptions and health policies surrounding its subjects of interest, analysing the content can shed light on the public discourse regarding opioid use.
Jul 5, 2020

Cannabis use disorder is correlated with increased risk of myocardial infarction after surgery

With the recent legalization of recreational cannabis use, cannabis consumption has become more prevalent. However, many health aspects around chronic cannabis use are still unclear, such as whether the cannabis use impacts surgical outcomes in patients.


IASP World Congress on Pain (Rescheduled to 2021)

June 27 to July 1, 2021
Amersterdam, The Netherlands
Alert:  Early bird registration open until February 10, 2021
Click HERE for further information and to register

IASP's Global Year for the Prevention of Pain

January marked the launch of IASP's 2020 Global Year for the Prevention of Pain. IASP sponsors and promotes the Global Year For Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Dec 28, 2020

Schwann cells and trigeminal neuralgia

Molecular Pain, Volume 16, Issue , January-December 2020.
Schwann cells are components of the peripheral nerve myelin sheath, which supports and nourishes axons.
Dec 28, 2020

Animal models of trigeminal neuralgia: A commentary

Molecular Pain, Volume 16, Issue , January-December 2020.
Dec 28, 2020

Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain

Molecular Pain, Volume 16, Issue , January-December 2020.
BackgroundMyofascial pain syndrome (MPS) is an important clinical condition that is characterized by chronic muscle pain and a myofascial trigger point (MTrP) located in a taut band (TB).
Dec 20, 2020

IPSE, a parasite-derived, host immunomodulatory infiltrin protein, alleviates resiniferatoxin-induced bladder pain

Molecular Pain, Volume 16, Issue , January-December 2020.
The transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor is an important mediator of nociception and its expression is enriched in nociceptive neurons.
Dec 15, 2020

Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes

Molecular Pain, Volume 16, Issue , January-December 2020.
The embryonic rat dorsal root ganglion (DRG) neuron-derived 50B11 cell line is a promising sensory neuron model expressing markers characteristic of NGF and GDNF-dependent C-fibre nociceptors.