Jun 8, 2015

WHO backs U of T professor's recommendations for reducing pain of vaccines

Apr 27, 2015

An end to cancer pain?

A new study led by University of Toronto researcher Dr. David Lam has discovered the trigger behind the most severe forms of cancer pain.
Apr 14, 2015

Announcement: Dr. Mike Salter appointed Chief of Research at the Hospital for Sick Children

Dr. Mike Apok, President and CEO at the Hospital for Sick Children announces the appointment of Dr. Michael Salter to the position of Chief of Research:


Call for Applications

2015/16 UTCSP Pain Scientist Scholarship
Application Deadline:  July 15, 2015
For complete Award details and application forms, please click on the following LINK

Pain Management: The Role of Opioids, Addiction Medicine and "End of Life" Decisions

12th Annual Pain Day Event - Queen's University
June 18, 2015

This is a multidisciplinary conference featuring leading experts in chronic pain management
For program details and to register, please click on the LINK
Click HERE for a registration form

Pain Interprofessional Curriculum Design (PICD) Workshop

sponsored by the University of Toronto Centre for the Study of Pain
in association with the Centre for Interprofessional Education
October 28-30, 2015
For program details and to register, please click HERE

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

Jun 2, 2015

The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (&#945;<sub>M</sub>&#946;<sub>2</sub>, CD11b/CD18)

Opioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation and cytokine production. The mechanisms whereby opioid peptides induce leukocyte responses are poorly understood.
May 30, 2015

MTOR, a New potential target for chronic pain and Opioid-induced tolerance and hyperalgesia

Chronic pain is a major public health problem with limited treatment options. Opioids remain a routine treatment for chronic pain, but extended exposure to opioid therapy can produce opioid tolerance and hyperalgesia.
May 26, 2015

Novel expression pattern of neuropeptide Y immunoreactivity in the peripheral nervous system in a rat model of neuropathic pain

Neuropeptide Y (NPY) has been implicated in the modulation of pain. Under normal conditions, NPY is found in interneurons in the dorsal horn of the spinal cord and in sympathetic postganglionic neurons but is absent from the cell bodies of sensory neurons.
May 25, 2015

Released lipids regulate Transient Receptor Potential Channel (TRP)-dependent oral cancer pain

Pain in the head neck area is an early symptom in oral cancer, supporting the hypothesis that cancer cells control the activities of surrounding nociceptors at the site of the tumor. Several reports implicate TRPV1 and TRPA1 in cancer pain, although there is a large gap in knowledge since the mechanisms for tumor-induced activation of these TRP receptors are unknown.
May 20, 2015

Upregulation of T-type Ca<sup>2+</sup> channels in long-term diabetes determines increased excitability of a specific type of capsaicin-insensitive DRG neurons

Previous studies have shown that increased excitability of capsaicin-sensitive DRG neurons and thermal hyperalgesia in rats with short-term (2–4 weeks) streptozotocin-induced diabetes is mediated by upregulation of T-type Ca2+ current. In longer–term diabetes (after the 8th week) thermal hyperalgesia is changed to hypoalgesia that is accompanied by downregulation of T-type current in capsaicin-sensitive small-sized nociceptors.
May 17, 2015

Pain perception in acute model mice of Parkinson&#8217;s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Pain is the most prominent non-motor symptom observed in patients with Parkinson’s disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied.