Sep 18, 2015

Different Mechanisms of Spinal Cord Neuron Disinhibition in Neuropathic Pain Models Require Different Therapeutic Interventions

Exciting new research from Dr. Steven Prescott’s lab is working to bridge the gap between basic research on neuropathic pain etiology to possible clinical interventions to treat neuropathic pain. Dr. Steven Prescott is a UTCSP member and scientist at the Hospital for Sick Children. In this paper, lead author Dr. Kwan Lee uses a unique method to measure intact spinal cord neurons from alive, anaesthetized animals, overcoming disadvantages of ex-vivo methodologies.
Sep 18, 2015

A New Method to Detect Dishonesty in Self-Report Measures of Pain

Self-report is the most valid and frequently used measure of pain in both clinical and research settings. However, some individuals may be inclined to provide deceitful self-reports in certain situations (e.g. insurance fraud). Thus, it is desirable to have a reliable method to detect dishonesty in self-report. Recently, UTCSP alumni Dr. Aaron Kucyi demonstrated that the use of sensory interference during self-report may be a potential tool to identify feigned self-reports.
Aug 14, 2015

Inhibiting the pain trajectory with a fresh approach to perioperative care

Jul 20, 2015

Sex Differences In The Spinal Mechanisms Mediating Neuropathic Pain -- Implications Ror Pre-clinical Research

In a recently published article in Nature Neuroscience, the laboratory of Dr. Michael Salter and UTCSP trainee member Josiane Mapplebeck reported that female and male mice use different mechanisms in the mediation of neuropathic pain. Previous research has shown that microglia, a type of cell involved in neuroinflammatory processes, mediate pain hypersensitivity resulting from nerve injury. However, evidence for the role of microglia in neuropathic pain is based on pre-clinical research conducted predominantly using male rodents.  Consequently, Dr. Salter, in collaboration with Dr. Jeffrey Mogil at McGill University, investigated the spinal mechanisms mediating neuropathic pain in females. 
Jul 20, 2015

Individual Differences In Temporal Summation Of Pain Are Associated With Brain Connectivity

In a recent article in the Journal of Neuroscience, the lab of Dr. Karen Davis and UTCSP trainee member Joshua Cheng reported on their study of the association of temporal summation of pain (TSP) responses with structural differences in projections contributing to pain perception. TSP is characterized by an increased perception of pain resulting from a repeatedly administered painful stimulus. Previous research has reported significant individual differences in TSP. 
Jun 8, 2015

WHO Backs U of T Professor's Recommendations For Reducing Pain Of Vaccines



12th Academic Pain Day

As part of National Pain Awareness Week
"Clinical pearls for pain management"
hosted by The Ontario Pain Foundation
Wednesday, November 4, 2015
7:30 a.m. to 5:30 p.m.
Holiday Inn Hotel & Conference Centre
Burlington, Ontario

For full details, please click on the LINK

UTCSP Translational Seminar Series presents:

Stress, Anxiety, and Pain
Join us for a discussion on the latest advance in research and practice
Tuesday, November 10, 2015
5:30 p.m. to 6:30 p.m.
Health Sciences Building
155 College Street
Room 270, 2nd Floor


Save the Date!

UTCSP Annual Scientific Meeting
Tuesday, February 9, 2016
8:00 a.m. to 1:00 p.m.
Toronto Rehabilitation Institute
550 University Avenue

Pain Interprofessional Curriculum Design (PICD) Workshop

sponsored by the University of Toronto Centre for the Study of Pain
in association with the Centre for Interprofessional Education
October 28-30, 2015
For program details and to register, please click HERE

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

Sep 30, 2015

Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons

s) comprise at least nine pore-forming α subunits. 1.9 are the most frequently studied in primary sensory neurons located in the dorsal root ganglion and are mainly localized to the cytoplasm.
Sep 24, 2015

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Increased electrical activity in peripheral sensory neurons including dorsal root ganglia (DRG) and trigeminal ganglia neurons is an important mechanism underlying pain. Voltage gated sodium channels (VGSC) contribute to the excitability of sensory neurons and are essential for the upstroke of action potentials.
Sep 16, 2015

Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain

Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to model neuropathic pain. Because nociceptive information is first detected in skin, it is important to understand how alterations in peripheral innervation contribute to pain in each model.
Sep 16, 2015

Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy

Mitochondrial dysfunction is observed in various neuropathic pain phenotypes, such as chemotherapy induced neuropathy, diabetic neuropathy, HIV-associated neuropathy, and in Charcot-Marie-Tooth neuropathy. To investigate whether mitochondrial dysfunction is present in trauma-induced painful mononeuropathy, a time-course of mitochondrial function and bioenergetics was characterized in the mouse partial sciatic nerve ligation model.
Sep 16, 2015

Pirt contributes to uterine contraction-induced pain in mice

Uterine contraction-induced pain (UCP) represents a common and severe form of visceral pain. Nerve fibers that innervate uterine tissue express the transient receptor potential vanilloid channel 1 (TRPV1), which has been shown to be involved in the perception of UCP.
Sep 12, 2015

Alleviating neuropathic pain mechanical allodynia by increasing Cdh1 in the anterior cingulate cortex

Plastic changes in the anterior cingulate cortex (ACC) are critical in the pathogenesis of pain hypersensitivity caused by injury to peripheral nerves. Cdh1, a co-activator subunit of anaphase-promoting complex/cyclosome (APC/C) regulates synaptic differentiation and transmission.