Nov 21, 2014

Toronto General Hospital program uses new methods to prevent pain killer addictions after surgery

Acuptuncture, exercise, psychological techniques and non-opioid pain medications used to prevent patients from developing chronic pain.
Nov 19, 2014

Congratulations Dr. Bonnie Stevens!

Congratulations to Dr. Bonnie Stevens for her most recent achievement. On November 17 she was awarded the 2014 CIHR Knowledge Translation Award. She received her award at the Innovating Child and Family Health Conference sponsored by CIHR and IHDCYH in Ottawa.
Nov 4, 2014

Pain Squad App Now Available!

The Pain Squad App was developed by the iOUCH research team at The Hospital for Sick Children to help kids with cancer track their pain.  It is now available worldwide the in the Apple App Store.
Oct 2, 2014

Pain in Child Health (PICH) Announcement

PICH is pleased to announce TWO exciting releases on the PICH Program.


UTCSP Annual Scientific Meeting 2015

co-sponsored with the Hospital for Sick Children's Pain Centre
Tuesday, February 10, 2015
8:00 a.m. to 1:30 p.m.
Peter Gilgan Centre for Research & Learning
Classroom 2a,b and Gallery, 686 Bay Street
The Hospital for Sick Children

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long intiative designed to raise awareness of various aspects of pain. 

Pain in the News

Nov 18, 2014

Optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization

The rostral ventromedial medulla (RVM) is a key brainstem structure that conveys powerful descending influence of the central pain-modulating system on spinal pain transmission and processing. Serotonergic (5-HT) neurons are a major component in the heterogeneous populations of RVM neurons and in the descending pathways from RVM.
Nov 18, 2014

Enhanced behavioral responses to cold stimuli following CGRPalpha sensory neuron ablation are dependent on TRPM8

Calcitonin gene-related peptide-alpha (CGRPalpha) is a classic marker of peptidergic nociceptive neurons and is expressed in myelinated and unmyelinated dorsal root ganglia (DRG) neurons. Recently, we found that ablation of Cgrpalpha-expressing sensory neurons reduced noxious heat sensitivity and enhanced sensitivity to cold stimuli in mice.
Nov 18, 2014

Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice

Paclitaxel, which is widely used for the treatment of solid tumors, causes neuropathic pain via poorly understood mechanisms. Previously, we have demonstrated that lysophosphatidic acid (LPA) and its receptors (LPA1 and LPA3) are required for the initiation of peripheral nerve injury-induced neuropathic pain.
Nov 17, 2014

HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors

Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are key players in epigenetic regulation of gene expression. Analgesic activity by HDAC inhibitors has been reported in different pain models including inflammatory and neuropathic pain.
Nov 16, 2014

TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

Acute postoperative pain is one of the frequent reasons for pain treatment. However, the exact mechanisms of its development are still not completely clear.
Nov 16, 2014

Cannabinoid receptor 2 agonist attenuates pain related behavior in rats with chronic alcohol/high fat diet induced pancreatitis

Chronic Pancreatitis (CP) is a complex and multifactorial syndrome. Many contributing factors result in development of dysfunctional pain in a significant number of patients.