Sep 16, 2020

Media reporting strategies surrounding opioid usage can shape public opinion

The amount of media coverage surrounding opioid consumption has dramatically increased since the turn of the century. Since popular media has a major impact on public perceptions and health policies surrounding its subjects of interest, analysing the content can shed light on the public discourse regarding opioid use.
Jul 5, 2020

Cannabis use disorder is correlated with increased risk of myocardial infarction after surgery

With the recent legalization of recreational cannabis use, cannabis consumption has become more prevalent. However, many health aspects around chronic cannabis use are still unclear, such as whether the cannabis use impacts surgical outcomes in patients.
Apr 2, 2020

Ca2+-activated potassium channels modulate chronic pain-related anxiety behaviour

Anxious behaviour and anxiety disorders are common comorbidities in chronic pain patients. The anterior cingulate cortex (ACC) is an area of the brain that processes anxiety and the affective dimension (unpleasant feeling) of pain. However, within the central nervous system the molecular link of anxiety in chronic pain is unclear.
Apr 2, 2020

Functional brain changes are associated with neuropathic pain relief from ketamine treatment

Neuropathic pain is difficult to treat and significantly affects quality of life. Intravenous infusion of ketamine is a growing treatment option for patients with neuropathic pain and has been shown to provide effective and long-term pain relief. However, almost half of patients that receive this therapy do not achieve analgesic effectiveness. To explore this issue, UTCSP members Dr. Anton Rogachov, Dr. Rachael Bosma, and senior author Dr. Karen Davis, with their colleagues at the Krembil Brain Institute led a study examining brain functional activity in ketamine responders and non-responders.
Jan 31, 2020

Contrasting roles in acute and chronic pain of the growth factor, epiregulin.

Targeting the epidermal growth factor receptor (EGFR) family of proteins has proven to be analgesic in chronic pain animal models and in patients with chronic pain. Thus, in this study led by UTCSP scientist, Loren Martin, and McGill researcher, Luda Diatchenko, they aimed to determine whether there are genetic variants in EGFR-encoding genes or in genes of ligands of EGFR that correlate with chronic pain. 
Jan 31, 2020

A new clinical pain syndrome: Trigeminal neuralgia associated with a solitary pontine lesion

Trigeminal neuralgia (TN) is a facial pain disorder distinguished by extremely severe, electric shock-like attacks of pain to one side of the face. The pain is due to problems with the brain’s trigeminal nerve, which carries sensation from the face to the brain. Conventional magnetic resonance imaging of patients with TN typically does not reveal identifiable brain lesions or atrophy – essentially, their scan is completely normal. In a newly published article by UTCSP members, lead author Sarasa Tohyama with senior author Dr. Mojgan Hodaie and colleagues, identified a unique subgroup of patients with TN who present with a single, distinct lesion in the pontine region of the brainstem.


IASP World Congress on Pain (Rescheduled to 2021)

June 27 to July 1, 2021
Amersterdam, The Netherlands
Alert:  Early bird registration open until February 10, 2021
Click HERE for further information and to register

IASP's Global Year for the Prevention of Pain

January marked the launch of IASP's 2020 Global Year for the Prevention of Pain. IASP sponsors and promotes the Global Year For Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Sep 10, 2020

Global transcriptome analysis of rat dorsal root ganglia to identify molecular pathways involved in incisional pain

Molecular Pain, Volume 16, Issue , January-December 2020.
To develop non-opioid therapies for postoperative incisional pain, we must understand its underlying molecular mechanisms.
Sep 10, 2020

Exosomes as a new pain biomarker opportunity

Molecular Pain, Volume 16, Issue , January-December 2020.
Exosomes are extracellular microvesicles implicated in intercellular communication with ability to transfer cargo molecules, including protein, lipids, and nucleic acids, at both close and distant target sites.
Sep 3, 2020

Naked mole-rats lack cold sensitivity before and after nerve injury

Molecular Pain, Volume 16, Issue , January-December 2020.
Neuropathic pain is a chronic disease state resulting from injury to the nervous system.
Aug 31, 2020

Pain modulation effect on motor cortex after optogenetic stimulation in shPKCγ knockdown dorsal root ganglion-compressed Sprague-Dawley rat model

Molecular Pain, Volume 16, Issue , January-December 2020.
Neuropathic pain can be generated by chronic compression of dorsal root ganglion (CCD).
Aug 19, 2020

Novel RET agonist for the treatment of experimental neuropathies

Molecular Pain, Volume 16, Issue , January-December 2020.
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) alleviate symptoms of experimental neuropathy, protect and stimulate regeneration of sensory neurons in animal models of neuropathic pain, and restore their functional activity.
Aug 13, 2020

Endoplasmic reticulum–mitochondria interplay in chronic pain: The calcium connection

Molecular Pain, Volume 16, Issue , January-December 2020.
Chronic pain is a debilitating condition that affects roughly a third to a half of the world’s population.