Apr 12, 2021

Cage-lid hanging duration as a novel measurement of pain in mice

Even though chronic pain is a prevalent problem that many Canadians and people around the world suffer with, there has been little progress in effective treatment development for this condition. One of the potential reasons for this is that the functional outcome measurements of pain behaviour in pre-clinical rodent models may not be representative of the pain experience of human patients
Mar 8, 2021

Nerve transfers or tendon transfers for radial nerve injuries: which is better?

Radial nerve injuries are very common and can become a painful and disabling condition. Current treatment methods for radial nerve injury include reconstructive options such as tendon or nerve transfers. Most studies to date have focused on patient outcomes from tendon transfers, but not nerve transfers. This study by UTCSP scientist Dr. Christine Novak and colleagues aims to augment current literature and compare tendon transfer and nerve transfer outcomes in their ability to restore radial nerve function. It was hypothesized that both techniques would improve function and patient satisfaction but would vary in their advantages.
Apr 12, 2021

2021/22 UTCSP Pain Scientist Scholarship

Applications are now being accepted!
Application Deadline:  June 4, 2021
Please click HERE for full details and application forms

Mar 8, 2021

Digital app can help chronic pain sufferers manage their pain

Toronto (March 4, 2021) - For the first time, an app has been shown to reduce key symptoms of chronic pain. A UHN-led study evaluated the impact of Manage My Pain (MMP), a digital health solution developed by ManagingLife, on patients seen at the Iroquois Falls Family Health Team, and the Toronto Western and Toronto General Hospitals.
Feb 9, 2021

Mice display social transmission of pain through physical contact

Empathy, defined as the ability to understand, share, and respond to the emotional states of others, is considered a critical process for promoting attachment and long-term stability of social bonds. Empathetic behaviours are evolutionarily conserved among species and can range from simple, such as emotional contagion, to complex, such as perspective taking. Although empathy has been shown to be important in social structures, how empathy is established between individuals and the role of physical touch in empathy development remains unknown.
Jan 10, 2021

Myofascial Pain Syndrome is Associated with Lower Insulin-Like Growth Factor-2 Levels

Myofascial pain syndrome (MPS) is a musculoskeletal chronic pain disorder with pathological contraction of localized muscle fibers, resulting in local and referred pain. MPS is often caused by muscle injury or damage. Insulin-like growth factors, IGF-1 and IGF-2, are hormones that regulate muscle growth, differentiation, as well as muscle maintenance and repair. Pain resulting from MPS is thought to be due to biochemical changes at peripheral nociceptive neurons and IGF-1 has also been implicated in the nociceptive pathway. However, the role of IGF-2 has yet to be implicated in pain and whether IGFs contribute to MPS specifically have not been extensively investigated.
Dec 14, 2020

Inpatient stay duration after joint replacement is associated with pain intensity and opioid use

Knee and hip replacements are high volume, costly procedures and the need for these surgeries are on the rise in Canada. About 10% of elective joint replacement patients are recommended to be sent to inpatient rehabilitation. However, the factors that contribute to longer stays for patients have not been previously investigated. UTCSP scientist Dr. Andrea Furlan and colleagues hypothesized that patients with better pain improvement and less opioid consumption during the initial few post-surgical days will have overall shorter rehabilitation stays.


Trainee Opportunity!

The University of Toronto Centre for the Study of Pain has partnered with the Canadian Pain Society (CPS) to provide free registration for 10 Trainee Members to the 2021 CPS Annual Scientific Meeting, being held virtually April 28-30. Meeting details can be found here: https://www.canadianpainsociety.ca/2021-ASM
Priority will be given to given to CPS Trainee members who have never attended an CPS Annual Scientific Meeting or those who would become new Trainee Members of CPS.
To qualify, please fill out the form found here: https://forms.gle/n1A662wMerYfMmru9 (1-2 minutes to complete). This form will close on Friday April 16th, so act quickly! Selected applicants will be notified by email with instructions on how to receive their meeting registration. 

2021/22 UTCSP Pain Scientist Scholarship

Applications are now being accepted!
Application Deadline:  June 4, 2021
Click HERE for complete details and application forms

IASP World Congress on Pain (Rescheduled to 2021)

June 27 to July 1, 2021
Amersterdam, The Netherlands
Alert:  Early bird registration open until February 10, 2021
Click HERE for further information and to register

IASP's Global Year for the Prevention of Pain

January marked the launch of IASP's 2020 Global Year for the Prevention of Pain. IASP sponsors and promotes the Global Year For Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Apr 8, 2021

Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity

Molecular Pain, Volume 17, Issue , January-December 2021.
Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states.
Mar 31, 2021

Cellular and synaptic mechanisms for Parkinson’s disease-related chronic pain

Molecular Pain, Volume 17, Issue , January-December 2021.
Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease.
Mar 31, 2021

Review of complex regional pain syndrome and the role of the neuroimmune axis

Molecular Pain, Volume 17, Issue , January-December 2021.
BackgroundComplex regional pain syndrome (CRPS) is a progressive and painful disease of the extremities that is characterized by continuous pain inconsistent with the initial trauma.
Mar 31, 2021

SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury

Molecular Pain, Volume 17, Issue , January-December 2021.
BackgroundNeuropathic pain following peripheral nerve injury (PNI) is linked to neuroinflammation in the spinal cord marked by astrocyte activation and upregulation of interleukin 6 (IL-6), chemokine (C-C motif) ligand 2 (CCL2) and chemokine (C-X-C motif) ligand 1 (CXCL1), with inhibition of each individually being beneficial in pain models.MethodsWild type (WT) mice and mice with global or pGfap-cre- or pGFAP-cre/ERT2-driven Abcc8/SUR1 deletion or global Trpm4 deletion underwent unilateral sciatic nerve cuffing.
Mar 26, 2021

Cold pain sensitivity is associated with single-nucleotide polymorphisms of PAR2/F2RL1 and TRPM8

Molecular Pain, Volume 17, Issue , January-December 2021.
Pain sensitivity differs individually, but the mechanisms and genetic factors that underlie these differences are not fully understood.
Mar 20, 2021

Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain

Molecular Pain, Volume 17, Issue , January-December 2021.
Research presented here sought to determine if opioid induced tolerance is linked to activity changes within the PI3Kγ-AKT-cGMP-JNK intracellular signaling pathway in spinal cord or peripheral nervous systems.