Jul 24, 2014

A Tipping Point for Neuropathic Pain Research

Finding new treatments for neuropathic pain has thus far proved to be incredibly difficult. Many newly developed treatments in animal models have proved ineffective when translated to humans, or failed due to undesirable side effects. Dr. Stephanie Ratte from Steven Prescott’s Lab at the Hospital for Sick Children proposes in novel research why this may be the case.
Jul 29, 2014

Mark Your Calendars!

UTCSP Trainee Meet & Greet Event
Tuesday, September 23, 2014
4:30 p.m . to 6:30 p.m.
Room 208, 155 College Street
Health Sciencies Building, U of T

Graduate students interested in and/or conducting research in the area of pain are invited to learn about the UTCSP and meet some of its members at this informal event.  Further details will be announced shortly.
Jul 29, 2014


Congratulations to Dr. Jennifer Stinson, nurse clinician scientist in the Child Health Evaluative Sciences program in the SickKids Research Institute and Nurse Practitioner with the Chronic Pain Service in the Department of Anaesthesia and Pain Medicine, as inaugural holder of the
Mary Jo Haddad Chair in Child Health on July 1, 2014.   In partnership with the Lawrence S. Bloomberg Faculty of Nursing, this Chair will create opportunities to advance pediatric nursing and generate knowledge through research that will ultimately improve current day practices and outcomes for children and adolescents
Jul 17, 2014

TEDTalk: How does your brain respond to pain?

Everyone experiences pain -- but why do some people react to the same painful stimulus in different ways? And what exactly is pain, anyway? Karen D. Davis walks you through your brain on pain, illuminating why the “pain experience” differs from person to person.
May 1, 2014

UTCSP Members Make Toronto Life's Top 30 List of Best Doctors in Toronto!

Congratulations to Allan Gordon (Pain Medicine) and John Flannery (Physiatry) for being recognized by Toronto Life Magazine as being the best in your field.
May 1, 2014

Better Care for Patients with Chronic Pain

Ontario giving health care providers more tools to help chronic pain patients. Ontario is improving care for patients suffering from chronic pain with new initiatives to ensure they receive appropriate treatment, diagnostic testing and medication. The province is working with the University Health Network on two intiatives that will help primary care providers care for chronic pain sufferers. 


Mark Your Calendars!

UTCSP Annual Scientific Meeting 2015
co-sponsored with the Hospital for Sick Children's Pain Centre
Tuesday, February 10, 2015
8:00 a.m. to 1:30 p.m.
Peter Gilgan Centre for Research & Learning
Classroom 2a,b and Gallery, 686 Bay Street
The Hospital for Sick Children
Pain Interprofessional Curriculum Design


Pain Interprofessional Curriculum Design (PICD) Workshop
hosted by the University of Toronto Centre for the Study of Pain
in association with the University of Toronto Centre for Interprofessional Education
November 12-14, 2014

National Jeans Day for Pain

Thursday, November 6, 2014
Sponsored by the Canadian Pain Coalition

For further details please click on the LINK

15th World Congress on Pain

Presented by the International Association for the Study of Pain (IASP)
October 6 - 11, 2014
Buenos Aires

For further details, please visit the IASP website by clicking on the following LINK

Pain in the News

Jul 29, 2014

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

HIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active antiretroviral therapy (HAART). Evidence shows that painful HIV sensory neuropathy is influenced by neuroinflammatory events that include the proinflammatory molecules, MAP Kinase, tumor necrosis factor-alpha (TNFalpha), stromal cell-derived factor 1-alpha (SDF1alpha), and C-X-C chemokine receptor type 4 (CXCR4).
Jul 23, 2014

Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the ¿ opioid receptor

Opioid analgesics are the most effective drugs for the treatment of moderate to severe pain. However, they also produce several adverse effects that can complicate pain management.
Jul 18, 2014

Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain

The molecular mechanisms underlying neuropathic pain are constantly being studied to create new opportunities to prevent or alleviate neuropathic pain. The aim of our study was to determine the gene expression changes induced by sciatic nerve chronic constriction injury (CCI) that are modulated by minocycline, which can effectively diminish neuropathic pain in animal studies.
Jul 7, 2014

Higher serum S100B and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia

Fibromyalgia (FM) is conceptualized as a central sensitization (CS) condition, that presents high serum brain-derived neurotrophic factor (BDNF) and neuroglia activation. Although the S100B protein regulates neuroglia functions, it has been traditionally used as a proxy of central nervous system damage.
Jul 3, 2014

Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity

Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve growth factor (NGF) is critical for the survival of developing primary sensory neurons.
Jun 25, 2014

Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors

Prolonged intracellular calcium elevation contributes to sensitization of nociceptors and chronic pain in inflammatory conditions. The underlying molecular mechanisms remain unknown but store-operated calcium entry (SOCE) components participate in calcium homeostasis, potentially playing a significant role in chronic pain pathologies.