Jul 17, 2014

TEDTalk: How does your brain respond to pain?

Everyone experiences pain -- but why do some people react to the same painful stimulus in different ways? And what exactly is pain, anyway? Karen D. Davis walks you through your brain on pain, illuminating why the “pain experience” differs from person to person.
Jul 17, 2014

UTCSP Members Make Toronto Life's Top 30 List of Best Doctors in Toronto!

Congratulations to Allan Gordon (Pain Medicine) and John Flannery (Physiatry) for being recognized by Toronto Life Magazine as being the best in your field.
Jul 17, 2014

Bonnie Stevens to receive CPS Distinguished Career Award

The Canadian Pain Society (CPS) has named Dr. Bonnie Stevens as the recipient of its Distinguished Career Award.  The Award will be presented at the annual meeting of CPS in Quebec City May 20-23. Award recipients are honored at a dinner May 22, and Dr. Stevens will present on her work at the meeting.
Jul 17, 2014

Better Care for Patients with Chronic Pain

Ontario giving health care providers more tools to help chronic pain patients. Ontario is improving care for patients suffering from chronic pain with new initiatives to ensure they receive appropriate treatment, diagnostic testing and medication. The province is working with the University Health Network on two intiatives that will help primary care providers care for chronic pain sufferers. 
Apr 14, 2014

Cognitive-behavioural therapy reduces our pain experience

Researchers at Toronto Western Hospital have uncovered empirical evidence that developing coping mechanisms not only helps people manage pain, but actually reduces the unpleasantness of the pain experience.
A two-photon image taken from a lamina I neuron that was filled with lucifer yellow (0.1%, green) during whole-cell recording.
Apr 14, 2014

GluN2B and GluN2D NMDA receptors dominate synaptic responses in the spinal cord

Recent research by the Salter lab at The Hospital for Sick Children has demonstrated that excitatory synaptic transmission of lamina I neurons in the spinal cord of rats differs significantly from the rest of the CNS.  The authors show that synaptic responses in lamina I neurons tend to be more prolonged than synaptic responses elsewhere in the CNS.
Jul 17, 2014

New! Oxford Textbook of Paediatric Pain

The Oxford Textbook of Paediatric Pain brings together an international team of experts to provide an authoritative and comprehensive textbook on all aspects of pain in infants, children and youth.
Dec 3, 2013

Mind Wandering Engages Pain-Relieving Pathways in the Brain

Everyone has experienced instances of their mind wandering away from tasks at hand. Recent evidence from UTCSP trainee Aaron Kucyi, in Dr. Karen Davis’ lab at Toronto Western Hospital, demonstrates that our minds wander even during pain, and that this is associated with increased engagement of pain-relieving pathways.
Dec 3, 2013

Novel Role of Gap Junctions Identified in Trigeminal Neuropathic Pain

This study provides the first evidence indicating a role of gap junctions in trigeminal neuropathic pain. Whether these gap junctions are specific to glia requires further investigation. Given that carbenxolone is already used for the clinical treatment of ulcers, it has the potential to be a safe and effective drug for the clinical treatment of trigeminal neuropathic pain. Therefore, investigation of the efficacy of carbenxolone in treating pain in humans is necessary.
Nov 6, 2013

It Doesn't Have to Hurt: Strategies for Helping Children with Shots and Needles. A Youtube Video for Parents

How many times have your kids been upset about going to the doctor because they’re afraid of the pain that goes along with getting a needle?  Every parent (and health professional) wants to know how getting a needle can be easier for everyone.


Mark Your Calendars!

UTCSP Annual Scientific Meeting 2015
co-sponsored with the Hospital for Sick Children's Pain Centre
Tuesday, February 10, 2015
8:00 a.m. to 1:30 p.m.
Peter Gilgan Centre for Research & Learning
Classroom 2a,b and Gallery, 686 Bay Street
The Hospital for Sick Children
Pain Interprofessional Curriculum Design


Pain Interprofessional Curriculum Design (PICD) Workshop
hosted by the University of Toronto Centre for the Study of Pain
in association with the University of Toronto Centre for Interprofessional Education
November 12-14, 2014

15th World Congress on Pain

Presented by the International Association for the Study of Pain (IASP)
October 6 - 11, 2014
Buenos Aires

For further details, please visit the IASP website by clicking on the following LINK

Global Year Against Orofacial Pain - October 2013 - October 2014

For More Information

How to Navigate Difficult Medical Conditions

11th Annual Pain Day Event
This is a multidisciplinary conference featuring leading experts in chronic pain
June 20, 2014
Delta Waterfront Hotel
Kingston, Ontario

For complete details and to register, click on the following LINK


Keystone Symposia on Molecular and Cellular Biology

The Brain: Adaptation and Maladaptation in Chronic Pain
June 15-20, 2014

Keystone Resort, Keystone, Colorado, USA
For more information regarding registration, important deadlines, and to view the full program, please follow the LINK

Understanding Pain in the Brain - UTCSP Cross-Talks

The first Cross-Talks seminar of the year was held on January 9, 2014 in the Peter Gilgan Centre for Research and Learning. Cross-talks are multidisciplinary seminars co-hosted by the Centre for Brain and Mental Health and the University of Toronto Center for the Study of Pain (UTCSP). This cross-talk focused on pain in the vulnerable brain.

Pain in the News

Jul 18, 2014

Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain

The molecular mechanisms underlying neuropathic pain are constantly being studied to create new opportunities to prevent or alleviate neuropathic pain. The aim of our study was to determine the gene expression changes induced by sciatic nerve chronic constriction injury (CCI) that are modulated by minocycline, which can effectively diminish neuropathic pain in animal studies.
Jul 7, 2014

Higher serum S100B and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia

Fibromyalgia (FM) is conceptualized as a central sensitization (CS) condition, that presents high serum brain-derived neurotrophic factor (BDNF) and neuroglia activation. Although the S100B protein regulates neuroglia functions, it has been traditionally used as a proxy of central nervous system damage.
Jul 3, 2014

Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity

Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve growth factor (NGF) is critical for the survival of developing primary sensory neurons.
Jun 25, 2014

Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors

Prolonged intracellular calcium elevation contributes to sensitization of nociceptors and chronic pain in inflammatory conditions. The underlying molecular mechanisms remain unknown but store-operated calcium entry (SOCE) components participate in calcium homeostasis, potentially playing a significant role in chronic pain pathologies.
Jun 24, 2014

CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy

Painful Diabetic Neuropathy (PDN) is a debilitating syndrome present in a quarter of diabetic patients that has a substantial impact on their quality of life. Despite this significant prevalence and impact, current therapies for PDN are only partially effective.