Aug 14, 2015

Inhibiting the pain trajectory with a fresh approach to perioperative care

Jun 8, 2015

WHO Backs U of T Professor's Recommendations For Reducing Pain Of Vaccines

Apr 27, 2015

An end to cancer pain?

A new study led by University of Toronto researcher Dr. David Lam has discovered the trigger behind the most severe forms of cancer pain.


UTCSP Trainee Welcome Event

Monday, September 21, 2015
4:30 p.m. to 6:00 p.m.
155 College Street, Room 208, 2nd Floor

Rehab Rounds

Hosted by the Department of Physical Therapy
"Exercise-induced hypoalgesia:  Facts and theories"
Dr. Irit Weissman-Fogel, BSc)PT, PhD
Assistant Professor, Dept. of Physical Therapy
Faculty of Social Welfare & Health Sciences, University of Haifa
Thursday, September 24, 2015
12:10 to 1:00 p.m.
Rehabilitation Sciences Building
500 University Avenue, Room 140

Click HERE for further details

Pain Interprofessional Curriculum Design (PICD) Workshop

sponsored by the University of Toronto Centre for the Study of Pain
in association with the Centre for Interprofessional Education
October 28-30, 2015
For program details and to register, please click HERE

IASP Global Year Against Neuropathic Pain

October 20, 2014 marks the launch of IASP's 2014/15 Global Year Against Neuropathic Pain.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

Pain in the News

Aug 18, 2015

Recruitment of dorsal midbrain catecholaminergic pathways in the recovery from nerve injury evoked disabilities

The periaqueductal gray region (PAG) is one of several brain areas identified to be vulnerable to structural and functional change following peripheral nerve injury. Sciatic nerve constriction injury (CCI) triggers neuropathic pain and three distinct profiles of changes in complex behaviours, which include altered social and sleep–wake behaviours as well as changes in endocrine function.
Aug 14, 2015

Short-term anesthesia inhibits formalin-induced extracellular signal-regulated kinase (ERK) activation in the rostral anterior cingulate cortex but not in the spinal cord

The rostral anterior cingulate cortex (rACC) has been implicated in the negative affective response to injury, and importantly, it has been shown that activation of extracellular signal-regulated kinase (ERK) signaling in the rACC contributes to the full expression of the affective component of pain in rodents. In this study, we investigated whether administration of anesthesia at the time of injury could reduce phosphorylated-ERK (PERK) expression in the rACC, which might eliminate the negative affective component of noxious stimulation.
Aug 11, 2015

p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats

Orofacial inflammatory pain is likely to accompany referred pain in uninflamed orofacial structures. The ectopic pain precludes precise diagnosis and makes treatment problematic, because the underlying mechanism is not well understood.
Aug 11, 2015

Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors

Although alterations in not only the pain sensitivity but also the analgesic effects of opioids have been reported under conditions of stress, the influence of unpredictable chronic mild stress (UCMS) on the antinociceptive effects of opioid analgesics remains to be fully investigated. The present study examined the influence of UCMS on the thermal pain sensitivity and antinociceptive effects of two opioid analgesics, morphine (an agonist of opioid receptors) and tramadol (an agonist of μ-opioid receptor and an inhibitor of both noradrenaline and serotonin transporters).
Aug 9, 2015

Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain

Koumine is an alkaloid monomer found abundantly in Gelsemium plants. It has been shown to reverse thermal hyperalgesia and mechanical allodynia induced by sciatic nerve chronic constriction injury (CCI) in rats in a dose-dependent manner.
Jul 31, 2015

KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia

Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. channels mediating M-currents, play a key role in neuronal excitability.