Mar 14, 2017

Reflecting on the 2017 UTCSP Annual Scientific Meeting

On February 28th, the UTCSP held its Annual Scientific Meeting at the Toronto Rehabilitation Institute. After a welcome and introduction by Drs. Hance Clarke, Rob Bonin, and Bonnie Stevens, attendees had the opportunity to hear from several speakers, including UTCSP faculty and trainees with expertise in both basic and clinical pain research.
Mar 14, 2017

Structural neuroimaging reveals the peripheral and central contributions to trigeminal neuralgia pain

Trigeminal neuralgia (TN) is a chronic neuropathic facial pain disorder, considered as one of the most painful conditions known to medicine. The characteristic feature of TN involves severe episodes of electric shock-like unilateral facial pain. Since a viable animal model of TN has not been established, the etiology and pathophysiological mechanisms of TN remains elusive. In a recent review article, UTCSP members Drs. Danielle DeSouza, Mojgan Hodaie, and Karen Davis discuss their body of work on how structural magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), can reveal peripheral and CNS abnormalities of TN.
Mar 14, 2017

A microglial pannexin-1 mechanism is critical for morphine withdrawal

Morphine is the gold standard medication for pain management due to its potent analgesic properties. Unfortunately, morphine is also associated severe withdrawal symptoms including nausea, chills, and severe headaches. These symptoms often negatively impact a patient’s attempts to stop opiate-based therapies. As a result, there is significant interest in trying to alleviate negative side effects without attenuation of morphine’s analgesic effect. However, the current understanding of the mechanisms underlying withdrawal is limited.
Jan 23, 2017

Opioids, musculoskeletal disorders, and work-related outcomes

Musculoskeletal disorders (MSDs) such as strains, sprains, fractures, and arthritis are a common cause of work disability and absenteeism. Current guidelines suggest that opioid medications should be prescribed for MSDs only when pain is severe and unresponsive to non-opioid analgesics. However, in some cases best practice guidelines are not being followed and opioids are overprescribed for MSDs, potentially contributing to work disability. 
Jan 23, 2017

A sweet solution for reducing procedural pain in neonates

Sweet solutions have been repeatedly demonstrated to be analgesic in neonates undergoing medical procedures. Despite the extent of evidence for the efficacy of this intervention, clinical trials continue to be conducted using placebo/no-treatment groups. Thus, Dr. Bonnie Stevens and colleagues conducted a cumulative meta-analyses (CMAs) on the impact of sugar solutions on behavioural pain outcomes.
Nov 15, 2016

New e-Book!

The Basic Science of Pain
An Illustrated and Clinically Oriented Guide
Philip Peng Educational Series
Nov 9, 2016

Diurnal variations in chronic pain are mediated by glucocorticoid regulation of ATP

Diurnal variations in symptoms of chronic pain patients have been widely reported. However, the underlying mechanisms for this phenonemon have yet to be delineated. UTCSP scientist Michael Salter has collaborated with scientists in Japan to help reveal the molecular mechanisms underlying diurnal variations in pain hypersensitivity.


CONNAUGHT Summer Institute in Pain: Innovative Research Methods

University of Toronto Centre for the Study of Pain
July 17-21, 2017
Massey College, University of Toronto

Application Deadline:  April 15, 2017

​Click HERE for program information and application details

Transitioning from Actue to Chronic Pain - Changing Etiology and Treatment

Presented by UTCSP Translational Seminar Series
Wednesday, April 19, 2017
5:00 p.m. to 6:00 p.m.
Peter Gilgan Centre for Research & Learning
3rd Floor Multimedia Room (03.9320)
686 Bay Street

Postdoctoral Fellowship Opportunity

Changing Healthcare Professionals Infant Pain Practice (CHIPP) Research Program
Toronto, ON
July 2017 - June 2018

Application Deadline:  April 15, 2017

2017/18 Purdue Pharma QEII-GSST Award

Applications are now being accepted
Deadline:  March 31, 2017
For complete award details and application forms, please click on the following LINK


Louise & Alan Edwards Post-Doctoral Fellowship
in Pediatric Pain Research 2017
Application Deadline:  April 21, 2017

Click HERE for full details

Institute on Advancing Chronic Pain Assessment and Management

Lawrence S. Bloomberg Faculty of Nursing
Centre for Professional Development
April 27-28, 2017
 More Information

Canadian Pain Society 38th Annual Scientific Meeting

May 23-26, 2017
Halifax, Nova Scotia
For further information, please visit the CPS Website

IASP's Global Year Against Pain After Surgery

January marks the launch of IASP's 2017 Global Year Against Pain After Surgery.  IASP sponsors and promotes the Global Year Against Pain, which is a year-long initiative designed to raise awareness of various aspects of pain. 

For further information, please visit the IASP website

Pain in the News

Nov 15, 2016

A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain

Thomas J Schnitzer, Souraya Torbey, Kristi Herrmann, Gagan Kaushal, Renita Yeasted, A Vania Apkarian
Nov 15, 2016; 12:174480691-174480691
Research Article
Nov 15, 2016

Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain

Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cuie Lu, Hui Rong, Yue Sun, Wei Zhang, Zhengliang Ma, Xiaoping Gu
Nov 15, 2016; 12:174480691-174480691
Research Article
Nov 15, 2016

Spinal astrocytic activation contributes to mechanical allodynia in a rat model of cyclophosphamide-induced cystitis

Bolong Liu, Minzhi Su, ShaoJun Tang, Xiangfu Zhou, Hailun Zhan, Fei Yang, Wenbiao Li, Tengcheng Li, Juncong Xie
Nov 15, 2016; 12:174480691-174480691
Research Article
Nov 11, 2016

Differential contributions of vasopressin V1A and oxytocin receptors in the amygdala to pain-related behaviors in rats

Bryce Cragg, Guangchen Ji, Volker Neugebauer
Nov 11, 2016; 12:174480691-174480691
Short Report
Nov 11, 2016

Preventing painful age-related bone fractures: Anti-sclerostin therapy builds cortical bone and increases the proliferation of osteogenic cells in the periosteum of the geriatric mouse femur

Michelle L Thompson, Stephane R Chartier, Stefanie A Mitchell, Patrick W Mantyh
Nov 11, 2016; 12:174480691-174480691
Research Article
Nov 7, 2016

A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels

Harshvardhan Rolyan, Shujun Liu, Janneke GJ Hoeijmakers, Catharina G Faber, Ingemar SJ Merkies, Giuseppe Lauria, Joel A Black, Stephen G Waxman
Nov 7, 2016; 12:174480691-174480691
Research Article