Steven Prescott
MD, PhD
Steven Prescott is trained as a experimentalist, theoretician and clinician. His laboratory combines innovative experiments with computer simulations and mathematical analysis to uncover how the nervous system encodes information. Particular emphasis is placed on deciphering how somatosensory information is encoded and how that encoding is disrupted by nerve injury to produce the aberrant sensations associated with neuropathic pain. He was recently recruited from the University of Pittsburgh to Toronto where he is now a Scientist at the Hospital for Sick Children and Assistant Professor of Physiology at the University of Toronto. He is a former Rita Allen Scholar in Pain, the 53rd Mallinckrodt Scholar, and a CIHR New Investigator.
University:University of Toronto
Principal Faculty:Medicine
Principal Department/Program:Physiology
Principal Hospital Appointment(s):Hospital for Sick Children
Telephone:416-813-7654x28977
Fax Number:416-813-7921
Major Research/Education Interests: neural coding regulation of cellular and network excitability synaptic inhibition and chloride regulation
Key Publications: (1)  Ratté, S., Hong, S., De Schutter, E., & Prescott, S.A. (2013). Impact of neuronal properties on network coding: roles of spike initiation dynamics and robust synchrony transfer. Neuron, 78(5), 758-72.     (2)  Rho, Y.A. & Prescott, S.A. (2012). Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. PLoS Computational Biology, 2012; 8, e1002524.    (3)  Prescott SA & Ratté S. Pain processing by spinal microcircuits: afferent combinatorics. Current Opinion in Neurobiology, 22, 631-639.    (4)  Hong, S., Ratté, S., Prescott, S.A. & De Schutter, E. (2012). Single neuron firing properties impact correlation-based coding. Journal of Neuroscience, 32, 1413-1428.   (5)  Ratté, S. & Prescott, S.A. (2011). ClC-2 channels regulate neuronal excitability, not intracellular chloride levels. Journal of Neuroscience, 31, 15838-15843.