Prediction of response to ketamine treatment using quantitative sensory testing and brain imaging in patients with neuropathic pain
To address this gap in knowledge, UTCSP members Rachael Bosma and senior author Dr. Karen Davis, with their colleagues at the Krembil Brain Institute led a study to investigate whether quantitative sensory testing and brain imaging measures can predict neuropathic pain patient response to ketamine infusion. Specifically, the authors assessed temporal summation of pain and brain dynamic functional connectivity before treatment, two measures that show individual differences in patients with neuropathic pain. After classifying patients as ketamine responders or non-responders, they found that the responders showed significantly higher temporal summation of pain and increased dynamic connectivity in the descending antinociceptive pathway compared to non-responders before ketamine treatment. These findings provide insight into the mechanisms underlying pain relief from ketamine infusion in patients with neuropathic pain. Furthermore, the identification of pre-treatment measures that predict response to ketamine infusion may lead to opportunities for a personalized approach to pain treatment.
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Reference: Bosma RL, Cheng JC, Rogachov A, Kim JA, Hemington KS, Osborne NR, Venkat Reghavan L, Bhatia A, Davis KD. (2018). Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion. Anesthesiology.