Zhaolei Zhang, Ph.D.

 Curriculum Vitae


160 College Street, Room 608
Donnelly Centre for Cellular & Biomolecular Research (CCBR)
University of Toronto
Toronto, ON M5S 3E1, Canada
Tel:   (416) 946-0924
Email: Zhaolei - dot - Zhang -AT- utoronto.ca
Web: http://sites.utoronto.ca/zhanglab/

Professor - July 2014 to present
Associate Professor (with tenure) - July 2009 to June 2014
Assistant Professor (Tenure-stream) - Nov. 2004 to June 2009
Banting & Best Department of Medical Research (BBDMR) and
        Department of Molecular Genetics
University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada
Other affiliations: Donnelly Centre for Cellular and Biomolecular Research (CCBR);
Collaborative Graduate Program in Genome Biology & Bioinformatics
Department of Computer Science (Cross-appointed)

Post-doctoral Associate - Mar. 2001 - Oct. 2004
Yale University, New Haven, Connecticut, USA
Department of Molecular Biophysics and Biochemistry (MB&B)
Supervisor: Professor Mark Gerstein

Graduate Student Research Assistant - Oct. 1995 – Feb. 2001
University of California at Berkeley, Department of Chemistry and
Lawrence Berkeley National Laboratory (LBNL), Physical Bioscience Division, Berkeley, CA, USA
Supervisor: Dr. Ed Berry and Professor Sung-Hou Kim

University of California at Berkeley, Berkeley, CA, USA
Ph.D., Biophysics, December 2000,
Advisor: Professor Sung-Hou Kim
Thesis: Crystal Structural Studies of Avian Mitochondrial Cytochrome bc1 Complex



[113] Kim T, Tyndel MS, Kim HJ, Ahn J, Choi SH, Park HJ, Kim Y, Yang D, Lee J, Jung S, Kim SY, Min YH, Cheong J, Sohn SK, Moon JH, Choi M, Lee M, Zhang Z, Kim DD "The clonal origins of leukemic progression of myelodysplasia" Leukemia (To Appear)

[112] Leach MD, Kim T, DiGregorio S, Collins C, Zhang Z, Duennwald ML, and Cowen LE "Candida albicans is Resistant to Polyglutamine 1 Aggregation and Toxicity" G3:Genes Genomes Genetics 2016 

[111] Kim T, Tyndel Ms, Kim HJ, Ahn J, Choi SH, Park H, Kim Y, Kim SY, Lipton JH, Zhang Z*, Kim DD* "Spectrum of somatic mutation dynamics in chronic myeloid leukemia following tyrosine kinase inhibitor therapy" Blood 2016

[110] Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, Luke B, Muzi-Falconi M, Myers CL, Mitra RD, Shore D, Brown GW, Zhang Z, Boone C, Andrews BJ. "Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci" Cell Systems 2016 Sep 28;3(3):264-277 PMID: 27617677 

[109] Olsen JB, Wong L, Deimling S, Miles A, Guo H, Li Y, Zhang Z, Greenblatt JF, Emili A, Tropepe V. "G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis" Stem Cell Reports 2016 Sep 13;7(3):454-70.

[108] Paul JM, Toosi B, Vizeacoumar FS, Bhanumathy KK, Li Y, Gerger C, El Zawily A, Freywald T, Anderson DH, Mousseau D, Kanthan R, Zhang Z, Vizeacoumar FJ, Freywald A. "Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment." Oncotarget 2016 Jul 13. doi: 10.18632/oncotarget.10569

[107] Dibitetto D, Ferrari M, Rawal CC, Balint A, Kim T, Zhang Z, Smolka MB, Brown GW, Marini F, Pellicioli A. "Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks" Nucleic Acids Research 2016 Jan 29;44(2) PMID: 26490958 

[106] Yimit A, Kim T, Anand RP, Meister S, Ou J, Haber JE, Zhang Z, Brown GW. "MTE1 Functions with MPH1 in Double-Strand Break Repair." Genetics 2016 May 203(1) PMID: 26920759 

[105] Gu Z, Jin K, Crabbe MJ, Zhang Y, Liu X, Huang Y, Hua M, Nan P, Zhang Z, Zhong Y. "Enrichment analysis of Alu elements with different spatial chromatin proximity in the human genome." Protein Cell 2016 April; 7(4) PMID: 26861146 

[104] Kim T, Yoshida K, Kim YK, Tyndel MS, Park HJ, Choi S, Ahn J, Jung S, Yang D, Lee J, Kim HJ, Kong G, Ogawa S, Zhang Z, Kim HJ and Kim D "Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression" Leukemia 2016 Feb;30(2) PMID: 26424407 

[103] Li, J., Ma, Z., Shi, M., Malty, R.H., Aoki, H.A., Jin, K., Phanse, S., Minic, Z., Wall, D.P., Zhang, Z., Urban, A.E., Hallmayer, J., Babu, M., and Snyder, M. "Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders" Cell Systems 2015 Vol 1 (5)

[102] Wong KC*, Li Y, Peng C, Moses AM, Zhang Z* "Computational Learning on Specificity-Determining Residue-Nucleotide Interactions" Nucleic Acids Research 2015 Nov 2 (Advanced Access) PMID: 26527718

[101] Jablonowski CM, Cussiol JR, Oberly S, Yimit A, Balint A, Kim T, Zhang Z, Brown GW and Smolka MB "Termination of Replication Stress Signaling via Concerted Action of the Slx4-Rtt107 Scaffolds" Genetics 2015 2015 Nov;201(3)

[100] Balint A, Kim T, Gallo D, J.R. C, Bastos de Oliveira FM, Yimit A, Ou J, Nakato R, Gurevich A, Shirahige K, Smolka MB, Zhang Z, Brown WG. "Assembly of Slx4 Signaling Complexes Behind DNA Replication Forks." EMBO Journal, 2015 Aug 13;34(16)

[99] Li Y, Wang Y, Zhang Z, Zamudio AV and JC Zhao "Genome-wide detection of high abundance N6-methyladenosine sites by microarray" RNA 2015 Aug;21(8):1511-8.

[98] Li Y, and Zhang Z "Computational Biology in microRNA" Wiley Interdiscip Rev RNA. 2015 Jul-Aug;6(4):435-52

[97] Liang C, Li Y, Luo J and Zhang Z "A novel motif-discovery algorithm to identify co-regulatory motifs in large transcription factor and microRNA co-regulatory networks in human " Bioinformatics. 2015 Jul 15;31(14):2348-55.

[96] Jin K, Musso G, Vlasblom J, Jessulat M, Deineko V, Negroni J, Mosca R, Malty R, Nguyen-Tran DH, Aoki H, Minic Z, Freywald T, Phanse S, Xiang Q, Freywald A, Aloy P, Zhang Z*, Babu M.* "Yeast mitochondrial protein-protein interactions reveal diverse complexes and disease-relevant functional relationships." Journal of Proteome Research 2015 Feb 6;14(2):1220-37

[95] Malty R, Jessulat M, Jin K, Musso G, Vlasblom J, Phanse S, Zhang Z, and Babu M "Mitochondrial Targets for Pharmacological Intervention in Human Diseases" Journal of Proteome Research 2015 Jan 2;14(1):5-21 , PMID: 25367773

[94] Wong KC, Li Y, Peng C and Zhang Z "SignalSpider: Probabilistic Pattern Discovery on Multiple Normalized ChIP-Seq Signal Profiles" Bioinformatics 2015 Jan 1;31(1):17-24, PMID: 25192742

[93] Yang L, Wang Y, Zhang Z, He S "Comprehensive transcriptome analysis reveals accelerated genic evolution in a Tibet fish, Gymnodiptychus pachycheilus." Genome Biology and Evolution, 2014 Dec 26. [Epub ahead of print], PMID: 25543049

[92] Li Y, and Zhang Z "Potential microRNA-mediated oncogenic intercellular communication revealed by pan-cancer analysis" Scientific Reports 2014 (In Press )

 [91] Cromar, G., Wong, K-C., Loughran, N.B., On, T., Song, H., Xiong, X., Zhang, Z. and Parkinson, J. "New tricks for ‘old’ domains: How novel architectures and promiscuous hubs contributed to the organization and evolution of the ECM" Genome Biology and Evolution 2014 (In Press)

 [90] Li Y, Liang M and Zhang Z "Regression Analysis of Combinatorial Gene Expression Regulation in Acute Myeloid Leukemia" PLOS Computational Biology, 2014 October

 [89] Li Y, Liang C, Easterbrook S, Luo J, Zhang Z "Investigating functional implication of reinforcing feedback loop in transcriptional regulatory network" Molecular Biosystems, 2014

[88] Li Y, Liang C, Wong KC, Luo J and Zhang Z "Mirsynergy: detecting synergistic miRNA regulatory modules by overlapping neighbourhood expansion" Bioinformatics 2014

[87] Li Y, Liang C, Wong KC, Jin K, and Zhang Z "Inferring probabilistic miRNA-mRNA interaction signatures in cancers: a role-switch approach" Nucleic Acids Research 2014

[86] Li J, Kim T, Nutiu R, Ray D, Hughes TR and Zhang Z "Identifying mRNA Sequence Elements for Target Recognition by Human Argonaute Proteins" Genome Research 2014

[85] Wong KC and Zhang Z "SNPdryad: Predicting Deleterious Non-synonymous Human SNPs Using Only Orthologous Protein Sequences" Bioinformatics 2014

[84] Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z, and Zhao J. "N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells" Nature Cell Biology 2014 (

[83] Zheng D. and Zhang Z "Pseudogene Evolution in the Human Genome" eLS 2013, John Wiley & Sons Ltd: Chicheste [DOI: 10.1002/9780470015902.a0020836.pub2]

[82] Li Y, Goldenberg A, Wong KC, and Zhang Z. "A probabilistic approach to explore human miRNA targetome by integrating miRNA-overexpression data and sequence information" Bioinformatics. Advanced Online October 2013

[81] Zhao D.Y., Li Y., Greenblatt J.F., ang Zhang Z., "ncRNA–Protein Interactions in Development and Diseases from the Perspective of High-Throughput Studies", book chapter in "Systems Analysis of Chromatin-Related Protein Complexes in Cancer", Springer, (In Press)

[80] Choi H*, Jung C*, Sohn S.*3, Kim S., Kim H., Kim Y., Kim T., Zhang Z., Shin E., Lee J., Moon J., Kim S., Kim K., Mun Y., Kim H., Park J., Kim J. and Kim D., "Genome-wide genotype-based risk model for survival in acute myeloid leukemia patients with normal karyotype" British Journal of Haematology 2013 (in press)

[79] Wong KC, Chan TM, Peng C., Li Y., and Zhang Z. "DNA Motif Elucidation using belief propagation" Nucleic Acids Research 2013

[78]Snider J., Hanif A., Lee M.E., Jin K., Yu A.R., Chuk M., Damajanovic D., Graham C., Wierzbicka M., Tang P., Balderes D., Wong V., San Luis B., Shevelev I., Sturley S.L., Boone C., Greenblatt J.F., Babu M., Zhang Z., Paumi C.M., Park H., Michaelis S., and Stagljar I. "Mapping the functional yeast ABC transporter interactome." Nature Chemical Biology 2013 (in press)

[77] Li Y., Zhao D.Y., Greenblatt J., and Zhang Z. "RIPSeeker: a statistical package for identifying protein-associated transcripts from RIP-seq experiments" Nucleic Acids Research, 2013

[76] Li J. and Zhang Z. "microRNA Regulatory Variation in Human Evolution" Trends in Genetics Volume 29, Issue 2, February 2013, Pages 116–124

[75] Yang Z., Dong D., Zhang Z., Crabbe M J C, Wang L and Yang Zhong "Preferential regulation of stably expressed genes in the human genome suggests a widespread expression buffering role of microRNAs" BMC Genomics 2012, 13(Suppl 7):S14

[74] Li J.(e)., Liu Y.(e), Xin X., Kim T., Cabeza, EA, Ren J., Nielsen R., Wrana JL*, Zhang Z* "Evidence for positive selection on a number of microRNA regulatory interactions during recent human evolution" PLoS Genet. 2012 Mar;8(3):e1002578

[73] Jin K., Li J., Vizeacoumar FS., Li Z., Min R., Zamparo L., Vizeacoumar FJ, Datti A., Andrews B.*, Boone C.*, Zhang Z.* "PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae" Nucleic Acids Research, Database Issue (2012)

[72] Li Z., Vizeacoumar FJ, Bahr S., Li J., Warringer J., Vizeacoumar FS, Min R., VanderSluis B., Bellay J., Devit M., Fleming JA, Stephens A., Hasse J., Lin Z., Baryshnikova A., Lu H.m Yan Z., Jin K., Barker S., Datti A.m Giaever G., Nislow C., Bulawa C., Myers CL, Costanzo M., Gingas A., Zhang Z., Blomberg A., Bloom K., Andrews B*., Boone C.* “Systematic Exploration of Essential Yeast Gene Function with Temperature sensitive Mutants” Nature Biotechnology 2011

[71] Li J., Yuan Z., and Zhang Z. "The cellular robustness by genetic redundancy in budding yeast" PLOS Genetics (2010, November 04)

[70] Dong D., Shao X., Deng N. and Zhang Z. "Differential effects of chromatin regulators and transcription factors on gene regulation: A nucleosomal perspective" Bioinformatics (2010, November)

[69] Turinsky AL, Turner B., Borja R., James Gleeson J. Heath M., Pu S., Switzer T., Dong D., Gong Y., On T., Xiong X., Emili E., Greenblatt J., Parkinson J., Zhang Z., Shoshana WJ "DAnCER: Disease-Annotated Chromatin Epigenetics Resource" Nucleic Acids Research (2011 Database issue)

[68] Dong D., Yuan Z., and Zhang Z. "Evidences and mechanisms for the increased expression variation of duplicate genes in budding yeast: from cis- to trans- regulation effects" Nucleic Acids Research (2010, October)

[67] Dong D., Shao X., Deng N. and Zhang Z. "Gene expression variations are predictive for stochastic noise" Nucleic Acids Research (2010, September)

[66] Li J., Liu Y., Kim T., Min R., and Zhang Z. "Gene expression variability within and between human populations and implications toward disease susceptibility" PLOS Computational Biology (2010, August)

[65] Li J., Min R., Vizeacoumar FJ, Jin K., Xin X., Zhang Z. "Exploiting the determinants of stochastic gene expression in S. cerevisiae for genome-wide prediction of expression noise" PNAS (2010, May 20)

[64] Min R., van der Maaten L., Yuan Z., Bonner A., Zhang Z. "Deep Supervised T-Distributed Embedding" 27th International Conference on Machine Learning (ICML 2010)

[63] On, T., Xiong, X., Pu, S., Turinsky, A., Gong, Y., Emili, A., Zhang, Z., Greenblatt, J., Wodak, SJ. and Parkinson, J. "The evolutionary landscape of the chromatin modification machinery" Proteins 2010 Jul;78(9):2075-89

[62] Li J., Yuan Z., Zhang Z. "Revisiting the contribution of cis elements to expression divergence between duplicated genes: the role of chromatin structure" Molecular Biology and Evolution (2010, Feb. 5)

[61] Vizeacoumar FJ., van Dyk N., Vizeacoumar FS., Cheung V., Li J., Sydorskyy Y., Case N., Li Z., Datti A., Nislow C., Raught B., Zhang Z., Frey B., Bloom K., Boone C.# and Andrews B.J.# "Integrating High-throughput Genetic Interaction Mapping and High-content Screening to Explore Yeast Spindle Morphogenesis" Journal of Cell Biology, 2010 Jan 11;188(1):69-8

[60] Li R., Fan W., ... Zhang Z., ... Dong D., Cook K., ... Yang H., Wang J., Wang J., (total co-123 authors) "The sequence and de novo assembly of the giant panda genome" Nature 2010 Jan 21;463(7279):311-7. Epub 2009 Dec 1

[59] Li J., Liu Y., Dong D., Zhang Z. "Evolution of an X-linked primate-specific microRNA cluster" Molecular Biology and Evolution 2009 Nov 19. [Epub ahead of print]

[58] Ren J., Jiang C., Gao X., Liu Z., Yuan Z., Jin C., Wen L., Zhang Z.*, Xue Y.*, Yao X.* "PhosSNP:systematic analysis of genetic polymorphisms that influence protein phosphorylation" Molecular & Cell Proteomics, 2009 Dec 8. [Epub ahead of print]

[57] Feng, Z.-P., Zhang, Z., van Kesteren, R.E., Straub, V.A., van Nierop, P., Jin, K., Nejatbakhsh, N., Goldberg, J.I., Spencer, G.E., Yeoman, M.S., Wildering, W., Coorssen, J.R., Croll, R.P., Buck, L., Syed, N.I., Smit, A.B., "Transcriptome analysis of the central nervous system of the mollusc Lymnaea stagnalis" BMC Genomics ( 2009)

[56] Min R., Stanley D.A., Yuan Z., Bonner A., and Zhang Z., "A Deep Non-Linear Feature Mapping for Large-Margin kNN Classification" IEEE International Conference on Data Mining (ICDM 2009)

[55] Li J.*, Min R.*, Bonner A., and Zhang Z., "A Probabilistic Framework to Improve microRNA Target Prediction by Incorporating Proteomics Data" Jounral of Bioinformatics and Computational Biology (2009)

[54] Guo X., Zhang Z., Gerstein M., and Zheng D. "Small RNAs Originated From Pseudogenes, cis- or trans-Acting? " PLOS Computational Biology (2009)

[53] Dong D., He G., Zhang S, and Zhang Z. "Evolution of olfactory receptor genes in primates dominated by birth-and-death process"" Genome Biology and Evolution (2009)

[52] Gong Y., Kakihara Y., Krogan N., Greenblatt J., Emili A., Zhang Z., Houry W. "An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: Implications to protein folding pathways in the cell " Molecular Systems Biology (2009)

[51] Kittanakom S, Chuk M, Wong V, Snyder J, Edmonds D, Lydakis A, Zhang Z, Auerbach D, Stagljar I. "Analysis of membrane protein complexes using the split-ubiquitin membrane yeast two-hybrid system." Methods in Molecular Biology (2009) 548:247-71

[50] Min R., Kuang R., Bonner A., and Zhang Z. "Learning Random-Walk Kernels for Protein Remote Homology Identification and Motif Discovery" SIAM International Conference on Data Mining (SDM09) (2009)

[49] Min R., Bonner A., Li J., and Zhang Z. "Learned Random-Walk Kernels and Empirical-Map Kernels for Protein Sequence Classification" Journal of Computational Biology (2009)

[48] Li J., Musso G., and Zhang Z. "Preferential regulation of duplicated genes by microRNAs in mammals" Genome Biology (2008)

[47] Borozan I., Chen L., Heathcote E.J., Edwards A., Katze M., Zhang Z. and I. McGilvray "MAID : An effect size based model for microarray data integration across laboratories and platforms" BMC Bioinformatcs (2008)

[46] Musso G., Costanzo M., Huangfu M., Smith A.M., Paw J., San Luis B., Boone C., Giaever G., Nislow C., Emili A.*, Zhang Z.* "The extensive and condition-dependent nature of epistasis among whole-genome-duplicates in yeast" Genome Research (2008)

[45] Gong Y., Zhang Z. "Global robustness and identifiability of random, scale-free and small-world networks. " Annals of the New York Academy of Sciences (2008)

[44] Davids W., Zhang Z., "The impact of horizontal gene transfer in shaping operons and protein interaction networks in E. coli - direct evidence of preferential attachment" BMC Evolutionary Biology (2008 )

[43] Gunewardena S., Zhang Z., "A Hybrid Model for Robust Detection of Transcription Factor Binding Sites" Bioinformatics (2008)

[42] Zheng D., Zhang Z., "Pseudogene Evolution In the Human Genome" Chapter in Handbook of Human Molecular Evolution, (John Wiley & Sons)

[41]Min R., Bonner A., and Zhang Z., "Modifying Kernels Using Label Information Improves SVM Classification Performance" International Conference on Machine Learning and Applications (ICMLA 2007)

[40] Gong Y., Zhang Z. "Alternative pathway approach for automating analysis and validation of cell perturbation networks and design of perturbation experiments" Annals of the New York Academy of Sciences (2007)

[39] Gong Y., Zhang Z. "CellFrame: a data structure for abstraction of cell biology experiments and construction of perturbation network" Annals of the New York Academy of Sciences (2007)

[38] Musso G., Zhang Z., and Emili A., "Experimental and Computational Procedures for the Assessment of Protein Complexes on a Genome-wide Scale " Chemical Reviews (2007)

[37] Mockli N., Deplazes A., Hassa P.O., Zhang Z., Peter M., Hottiger M.O., Stagljar I., Auerbach "A yeast split-ubiquitin based cytosolic screening system (cytoY2H) to detect interactions between transcriptionally active proteins. " Biotechniques (2007)

[36] Musso G., Zhang Z.*, and Emili A.*, "Retention of protein-protein interactions by ancient duplicated gene products in budding yeast" Trends in Genetics (2007)

[35] Karro J., Yan Y., Zheng D., Zhang Z., Cariero N., Harrison P., and Gerstein M. “Pseudogene.org: A comprehensive database and comparison platform for pseudogene annotation” Nucleic Acids Research (2007, database issue)

[34] Zhang Z.*, Pang A., Gerstein M. "Comparative analysis of genome tiling array data reveals many novel primatespecificfunctional RNAs in human. " BMC Evolutionary Biology (2007)

[33] Zhang Z., Carriero N., Zheng D., Karro J., Harrison P.M., Gerstein M., “PseudoPipe: an automated pseudogene identification pipeline” Bioinformatics (2006) 15;22(12):1437-9

[32] Gunewardena S.S.A, Jeavons, P. and Zhang, Z., "Finding transcription factor binding sites in DNA sequences: a template based approach" Journal of Computational Biology (2006) Vol. 13, No. 4: 929-945

[31] Gunewardena S.S.A and Zhang, Z., “Accounting For Physical properties And Nucleotide Polymorphisms in the Quantitative Prediction of DNA-protein Interactions” Pacific Symposium of Biocomputing 2006

[30] Gong Y. and Zhang Z., “Alternative signaling pathways: when, where and why?” FEBS Letters (2005) 579(24) 5265:5274

[29] Gunewardena S.S.A and Zhang, Z., “Finding Transcription Factor Binding Sites in DNA Sequences: A Template Based Approach.” Proceedings of the 13th IEEE Workshop on Statistical Signal Processing (SSP'05), Bordeaux, France, July 2005.

-- At Yale --
[28] Harrison, P., Zheng, D., Zhang, Z., Gerstein, M., "Transcribed processed pseudogenes in the human genome: An intermediate form of expressed retrosequence lacking protein-coding ability." Nucleic Acids Research (2005) 33(8):2374-83

[27] Zheng, D., Zhang, Z., Harrison, P.M., Karro, J., Carriero, N., and Gerstein M., "Integrated Pseudogene Annotation for Human Chromosome 22: Evidence for Transcription." Journal of Molecular Biology (2005) 349(1):27-45

[26] Zhang, Z. and Gerstein, M., “Large-scale Analysis of Pseudogenes in the Human Genome.” Current Opinion in Genetics & Development  (2004) 14(4):328-35

[25] Lehnert, U., Xia, Y., Royce T., Goh, C., Liu, Y., Senes, A., Yu, H., Zhang, Z., Engelman, D.M., and Gerstein, M., “Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions.” Quarterly Reviews of Biophysics(2004)

[24] Zhang, Z. and Gerstein, M., “Comparative analysis of processed pseudogenes in the mouse and human genomes.” Trends in Genetics(2004) 20:2 62-65

[23] Zhang, Z., Harrison, P., and Gerstein, M., “Millions of years of evolution preserved: a comprehensive catalogue of over 8000 pseudogenes in the human genome.” Genome Research (2003) 13:2541-2558

[22] Zhang, Z. and Gerstein, M. “Reconstructing Genetic Networks in Yeast.” Nature Biotechnology(2003) 21(11): 1295-97

[21] Zhang, Z. and Gerstein, M., “Patterns of nucleotide substitutions, insertions and deletions in the human genome as inferred from human pseudogenes.” Nucleic Acids Research (2003) 31 (18): 5338-48.

[20] Zhang, Z. and Gerstein, M., “Of mice and men: Phylogenetic footprinting Aids Regulatory Elements Discovery.” Journal of Biology(2003) 2:11

[19] Zhang, Z. and Gerstein, M., “The human genome has 49 cytochrome cpseudogenes, including a relic of a primordial gene that still functions in mouse.” Gene(2003) 312:61-72

[18] Harrison, P., Zhang Z., Milburn, D. and Gerstein, M., “Identification of pseudogenes in the Drosophila melanogastergenome.” Nucleic Acids Research(2003) 31:1033-37

[17] Zhang, Z. and Gerstein, M., “Mapping and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.” Genomics(2003) 81:468-80

[16] Zhang, Z., Harrison, P. and Gerstein, M., “Identification and analysis of over 2000 ribosomal protein pseudogenes in the human genome and implications for retrotransposition.” Genome Research(2002) 12: 1466-82

[15] Zhang, Z., Harrison, P., and Gerstein, M., “Digging Deep for Ancient Relics: A Survey of Protein Motifs in the Intergenic Sequences of Four Eukaryotic Genomes.” Journal of Molecular Biology(2002) 323: 811-22.

[14] Liu, Y., Luscombe, N., Alexandrov, V., Bertone, P., Harrison, P., Zhang, Z., and Gerstein, M., “Structure genomics: a new era for pharmaceutical research.” Genome Biology(2002) 3(2)

[13] Luscombe, N.M., Qian, J., Zhang, Z., Johnson, T., and Gerstein, M., “Power-law behavior applies to a wide variety of genomic properties.” Genome Biology(2002) 25; 3 (8).

[12] Echols, N., Harrison, P., Balasubramanian, S., Bertone, P., Johnson, T., Luscombe, N., Zhang, Z., and Gerstein, M., “Comprehensive analysis of amino acid and nucleotide composition in eukaryotic genomes, comparing genes and pseudogenes.” Nucleic Acids Research (2002) 30:10

[11] Balasubramanian, S., Harrison, P., Hegyi, H., Bertone, P., Luscombe, N., Echols, N., McGarvey, P., Zhang, Z., and Gerstein, M., “SNPs on human chromosome 21 and 22 – analysis in terms of protein features and pseudogenes.”  Pharmacogenomics(2002) 3(3).

-- At Berkeley --
[10] Zhang, Z. “Crystal structural studies of avian mitochondrial cytochrome bc1 complex.” Ph.D. Dissertation, UC Berkeley, 2000

[9] Berry, E., Zhang, Z., Bellamy, H., and Huang, L., “Crystallographic location of two Zn (2+)-binding sites in the avian cytochrome bc (1) complex.” Biochim Biophys Acta(2000) 1459 (2-3): 440-48.

[8] Zhang, Z., Berry, E., Huang, L., and Kim, S. -H., “Mitochondrial cytochrome bc1 complex.” Book chapter in Subcellular Biochemistry, volume 36. Plenum (2000) U.K.

[7] Chi, Y, Huang, L., Zhang, Z., Fernandez-Velasco, J., and Berry, E., “High resolution structure of a truncated form of cytochrome from Chlamydomonas reinhardtii.” Biochemistry (2000) 4; 39(26): 7689-701.

[6] Berry, E., Huang, L., Zhang, Z., and Kim S. -H., “Structure of the avian mitochondrial cytochrome bc1 complex.” J. Bioenerg. Biomembr. (1999) 3:177-90

[5] Crofts, A.R., Guergova-Kuras, M., Huang, L., Kuras, R., Zhang, Z., and Berry, E., “The mechanism of ubiquinol oxidation by the bc1 complex: the role of the iron sulfur protein, and its mobility.” Biochemistry(1999) 38(48): 15791-15806.

[4] Crofts, A., Hong, S., Zhang, Z., and Berry, E., “Physicochemical aspects of the movement of the Rieske iron sulfur protein during quinol oxidation by the bc1 complex.” Biochemistry(1999) 38(48): 15827-39.

[3] Berry, E., Zhang, Z., Huang, L., and Kim, S. -H., “Structures of quinone-binding sites in be complexes: functional implications.” Biochemical Society Transactions(1999) 27(4): 565-72.

[2] Saribas, A.S., Valkova-Valchanova, M., Tokito, M.K., Zhang, Z., Berry, E., and Daldal, F., “Interactions between the cytochrome b, cytochrome c1, and Fe-S protein subunits at the ubihydroquinone oxidation site of the bc1 complex of Rhodobacter capsulatus.” Biochemistry(1998) 37(22): 8105-14.

[1] Zhang, Z., Huang, L., Shulmeister, V.M., Chi, Y., Kim, KK. Hung, L.-W., Crofts, A.R., Berry, E., and Kim, S. -H., “Electron transfer by domain movement in cytochrome bc1” Nature(1998) 392 (6677): 677-84