Publications for 2007
Refereed
(Peer reviewed):
Original Research:
Rashid
A.J., So C.H., Kong M.M.C., Furtak T., Cheng R., O’Dowd B.F. and George
S.R.
The D1-D2
dopamine receptor heterooligomer is coupled to rapid activation of Gq/11
in the striatum: Discovery of a novel agonist selectively targeting the
complex.
Proceedings of the National Academy of Science USA
2007; 104:
654-659
So C.,
Verma V., O’Dowd B.F. and George S.R.
Desensitization of the dopamine D1 and D2 dopamine receptor
heterooligomer mediated calcium signal by agonist occupancy of either
receptor.
Molecular Pharmacology
2007; 72: 450-462
Skrabanek
L., Murcia M., Bouvier M., Devi L., George S.R., Lohse M.J., Milligan
G., Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA,
Campagne F, Filizola M.
Requirements and ontology for a G protein-coupled receptor
oligomerization knowledge base.
BMC
Bioinformatics 2007; 8:177
O’Dowd
B.F., Alijaniaram M., Ji X., Nguyen T., Eglen R. and George S.R.
Utilizing
ligand induced conformational change to screen for compounds targeting G
protein coupled receptors.
J.
Biomolecular Screening
2007; 12:
175-185
Hasbi A.,
Nguyen T., Fan T., Cheng R., Rashid A.J., Alijaniaram M., Rasenick MM.,
O’Dowd B.F. and George S.R.
Trafficking of preassembled opioid
m-d
receptor heterooligomer-Gz signalling complexes to the plasma membrane:
co-regulation by agonists.
Biochemistry
2007; 46:
12997-13009
Kong M.M.,
Hasbi A., Mattocks M., Fan T., O’Dowd B.F. and George S.R.
Regulation of D1 dopamine receptor trafficking and signaling by
caveolin-1.
Molecular Pharmacology
2007; 72:
1157-1170
George SR
and O’Dowd BF.
A novel
dopamine receptor signaling unit in brain: Heterooligomers of D1 and D2
receptors.
The
Scientific World Journal
2007; 7:
58-63
Review
Articles:
El-Ghundi
M., O’Dowd B.F. and George, S.R.
Insights
into the role of dopamine in learning and memory.
Reviews in Neuroscience
2007; 18: 37-66
Rashid AJ,
O’Dowd BF, Verma V and George SR.
Neuronal
Gq-coupled dopamine receptors: An uncharted role for dopamine.
Trends
in Pharmacological Science
2007; 28:
551-555
Publications
for 2006
Refereed
(Peer reviewed):
Original
Research:
Kong,
M.M.C., Fan, T., Varghese, G., Lee S.P., O’Dowd, B.F. and George, S.R.
Selective
agonist rescue of an intracellularly retained oligomer of the D1
dopamine receptor.
Molecular Pharmacology
2006; 70: 78-89
Rashid
A.J., So C.H., O’Dowd B.F. and George S.R.
Heterooligomerization of D1 and D2 dopamine receptors in brain:
Implications for psychosis?
J
European Coll Neuropsychopharmacology
2006; 16: Supplement 4, S193
O’Dowd
B.F., Alijaniaram M., Ji X., Nguyen T., Eglen R. and George S.R.
Utilizing
ligand induced conformational change to screen for compounds targeting G
protein coupled receptors.
J.
Biomolecular Screening,
epub 2006; Dec
Rashid
A.J., So C.H., Kong M.M.C., Furtak T., Cheng R., O’Dowd B.F. and George
S.R.
The D1-D2
dopamine receptor heterooligomer is coupled to rapid activation of Gq/11
in the striatum: Discovery of a novel agonist selectively targeting the
complex.
Proceedings of the National Academy of Science USA,
epub 2006; Dec
Review
Articles:
Lee D.K., George S.R., O'Dowd B.F.
Unravelling the roles of the apelin system: prospective therapeutic
applications in heart failure and obesity.
Trends
in Pharmacological Science
2006; 27:190-194
Kong
M.M.C., O’Dowd B.F. and George S.R.
The
oligomerization of G protein coupled receptors. In: Cell Biology
of Addiction.
Cold
Spring Harbor Laboratory Press Reviews
2006; 271-290
El-Ghundi
M., O’Dowd B.F. and George, S.R.
Insights
into the role of dopamine in learning and memory.
Reviews in Neuroscience,
epub 2006 Oct.
Other:
Book Chapters, Monographs, Pharmacology Textbook
O’Dowd
B.F., Ji X., Alijaniaram M., Nguyen T. and George S.R.
A novel
drug screening assay for G protein coupled receptors.
In:
Ligand Design for G Protein-coupled Receptors, Vol. 30. Ed. D. Rognan,
Wiley-VCH, New York, pp 51- 60, 2006.
George
S.R. and Schimmer B.P.
Vasopressin, oxytocin and uterotonic drugs.
In: Principles of Medical Pharmacology, 7th Edition. H. Kalant, D. Grant
and J. Mitchell (eds.),
Elsevier,
Canada, pp. 603-612, 2006.
Schimmer
B.P. and George S.R.
Thyroid
hormones and antithyroid drugs.
In: Principles of Medical Pharmacology, 7th Edition. H. Kalant, D. Grant
and J. Mitchell (eds.),
Elsevier,
Canada, pp. 613-619, 2006.
George
S.R. and Schimmer B.P.
Gonadotropic and gonadal hormones.
In: Principles of Medical Pharmacology, 7th Edition. H. Kalant, D. Grant
and J. Mitchell (eds.),
Elsevier,
Canada, pp. 620-634, 2006.
Schimmer
B.P. and George S.R.
Insulin
and oral hypoglycemic drugs.
In: Principles of Medical Pharmacology, 7th Edition. H. Kalant, D. Grant
and J. Mitchell (eds.),
Elsevier,
Canada, pp. 635-646, 2006.
Schimmer
B.P. and George S.R.
Adrenocorticotropic hormone and adrenal steroids.
In: Principles of Medical Pharmacology, 7th Edition. H. Kalant, D. Grant
and J. Mitchell (eds.),
Elsevier,
Canada, pp. 647-657, 2006.
ABSTRACTS:
So, C.H.,
Rashid, A.J., Varghese, G., Cheng, R., O’Dowd, B.F. and George, S.R.
D1 and D2
dopamine receptors heterooligomerized co-activation generates a
phospholipase C-mediated calcium signal.
Visions
in Pharmacology, 2006.
Kong,
M.M.C., Yassa, M., Hasbi, A., O’Dowd, B.F. and George, S.R.
Functional regulation of the D1 dopamine receptor by Caveolin-1.
Visions
in Pharmacology, 2006.
Ng, J.,
Rashid, A.J., So, C.H., O’Dowd, B.F. and George, S.R.
Functional consequences of calcium signaling by dopamine D1 and D2
receptor hetero-oligomers.
Visions
in Pharmacology, 2006.
S. R.
George, A. Hasbi, T. Nguyen, M. Alijaniaram, B. F. O’Dowd
Heterooligomerization of mu and delta opioid receptors occurs during
biosynthesis to create novel agonist co-regulated units with a signaling
preference
Society
for Neuroscience, 2006.
B. F.
O'Dowd, M. Alijaniaram, X. Ji, T. Nguyen, R. M. Eglen, S. R. George
Utilizing
ligand occupied induced conformational change to screen for compounds
targeting orphan G-Protein coupled receptors
Society
for Neuroscience, 2006
Asim J.
Rashid, Christopher S. So, Brian F.O’Dowd and Susan R. George
A Gq/11-coupled
signaling unit in the brain composed of heterooligomeric D1 and D2
dopamine receptors: implications for schizophrenia?
European
College of Neuropsychopharmacology, 2006
Katerina
Venderova, Ahmed Hasbi, Jonathan M. Brotchie, Brian O’Dowd, Susan R.
George
Striatal
cannabinoid CB1 and dopamine D2 receptors form functional hetero-oligomers
that preferentially couple to stimulatory Gs-proteins
Parkinson’s Disease and other Disorders, 2006
Susan R.
George and Brian F. O’Dowd
Novel G
protein coupled receptor targets for drug discovery: Orphan receptors
and receptor heterooligomers
Royal
Chemical Society, 2006
D. K.
Lee, P. Seeman, S. S. Ferguson, S. R. George, B. F. O'Dowd
Differential intracellular trafficking of internalized apelin receptor
following treatment with apelin-13 and apelin-36
Society
for Neuroscience, 2006
Lee, D.K.,
George, S.R., Ferguson, S.S.G. and O’Dowd, B.F.
The fate
of the internalized apelin receptor is determined by different isoforms
of the apelin peptide.
Visions
in Pharmacology, 2006.
O’Dowd
BF, Ji X, Alijariaram M, George SR
Utilizing
structure-based conformational changes to screen for compounds
interacting with GPCRs
Great
Lakes GPCR Retreat, 2006
