The Rottapel Lab

PUBLICATIONS

2017

Matsumoto Y, Larose J, Kent OA, Lim M, Changoor A, Zhang L, Storozhuk Y, Mao X, Grynpas MD, Cong F, Rottapel R. RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146. J Clin Invest. 2017 Apr 3;127(4):1303-1315. doi: 10.1172/JCI90527. PubMed PMID: 28287403.

Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, Novikov I, Huertas P, Rottapel R, Sood AK, Izraeli S. Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer. Oncotarget. 2017 Mar 10:27380-27392. doi: 10.18632/oncotarget.16068. PubMed PMID: 28423708.

Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R. Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer. Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028. PubMed PMID: 28273451.

Kent OA, Sandí MJ, Burston HE, Brown KR, Rottapel R. An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.Oncotarget. 2017 Jan 17;8(3):4484-4500. doi: 10.18632/oncotarget.13152. PubMed PMID: 27835861

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2016

Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. PubMed PMID: 27797343.

Fine N, Dimitriou ID, Rullo J, Sandí MJ, Petri B, Haitsma J, Ibrahim H, La Rose J, Glogauer M, Kubes P, Cybulsky M, Rottapel R. GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.J Cell Biol. 2016 Oct 10;215(1):107-119. doi: 10.1083/jcb.201603109. PubMed PMID: 27738004.

Kent OA, Mendell JT, Rottapel R. Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1. Mol Cancer Res. 2016 Mar;14(3):267-77. doi: 10.1158/1541-7786.MCR-15-0456. Epub 2016 Jan 8. PubMed PMID: 26747707

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2015

Prod'Homme V, Boyer L, Dubois N, Mallavialle A, Munro P, Mouska X, Coste I, Rottapel R, Tartare-Deckert S, Deckert M. Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages. J Clin Invest. 2015 Apr;125(4):1396-400. doi: 10.1172/JCI71081. Epub 2015 Feb 23. PubMed PMID: 25705883; PubMed Central PMCID: PMC4396483.

Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y, Nishida K, Rottapel R, Ueki Y. Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice. Arthritis Rheumatol. 2015 Mar;67(3):656-67. doi: 10.1002/art.38975. PubMed PMID: 25470448; PubMed Central PMCID: PMC4342302.

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2014

Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL, Rottapel R, Brotto M, Reichenberger EJ, Ueki Y. SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss. J Bone Miner Res. 2014 Dec;29(12):2618-35. doi: 10.1002/jbmr.2295. PubMed PMID: 24916406

Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J, Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. Acta Crystallogr D Biol Crystallogr. 2014 Oct 1;70(Pt 10):2740-53. doi: 10.1107/S1399004714017660. Epub 2014 Sep 27. PubMed PMID: 25286857.

Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M, Rottapel R. Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1. Nat Commun. 2014 Sep 11;5:4857. doi: 10.1038/ncomms5857. PubMed PMID: 25209408.

Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J. Measuring error rates in genomic perturbation screens: gold standards for human functional genomics. Mol Syst Biol. 2014 Jul 1;10(7):733. doi: 10.15252/msb.20145216. PubMed PMID: 24987113.

Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL, Rottapel R, Brotto M, Reichenberger EJ, Ueki Y. SH3BP2 Cherubism Mutation Potentiates TNF-α-Induced Osteoclastogenesis Via NFATc1 and TNF-α-Mediated Inflammatory Bone Loss. J Bone Miner Res. 2014 Jun 10. doi: 10.1002/jbmr.2295. [Epub ahead of print] PubMed PMID: 24916406.

Cullis J, Meiri D, Sandi MJ, Radulovich N, Kent OA, Medrano M, Mokady D, Normand J, Larose J, Marcotte R, Marshall CB, Ikura M, Ketela T, Moffat J, Neel BG, Gingras AC, Tsao MS, Rottapel R. The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1. Cancer Cell. 2014 Feb 10;25(2):181-95. doi: 10.1016/j.ccr.2014.01.025. PubMed PMID: 24525234.

Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Res. 2014 Jan 31. PubMed PMID: 24487029.

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2013

Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, Wang Y, Brito GC, Kasimer D, Makhnevych T, Ketela T, Datti A, Babu M, Emili A, Pelletier L, Wrana J, Wainberg Z, Kim PM, Rottapel R, O'Brien CA, Andrews B, Boone C, Moffat J. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Mol Syst Biol. 2013 Oct 8;9:696. doi: 10.1038/msb.2013.54. PubMed PMID: 24104479; PubMed Central PMCID: PMC3817404.

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2012

Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P, Rottapel R. The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation. J Immunol. 2012 Jul 18. [Epub ahead of print] PubMed PMID: 22815290.

Borozan I, Wilson S, Blanchette P, Laflamme P, Watt SN, Krzyzanowski PM, Sircoulomb F, Rottapel R, Branton PE, Ferretti V. CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes. BMC Bioinformatics. 2012 Aug 17;13:206. doi: 10.1186/1471-2105-13-206. PubMed PMID: 22901030; PubMed Central PMCID: PMC3464663.

Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M. Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts. Methods. 2012 Jun 28. [Epub ahead of print] PubMed PMID: 22750304.

Meiri D, Marshall CB, Greeve MA, Kim B, Balan M, Suarez F, Bakal C, Wu C, Larose J, Fine N, Ikura M, Rottapel R. Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition. Mol Cell. 2012 Mar 9;45(5):642-55. Erratum in: Mol Cell. 2012 Mar 30;45(6):844. Bakal, Chris [added]. PubMed PMID: 22405273.

Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, Vizeacoumar FS, Datti A, Kasimer D, Buzina A, Mero P, Misquitta C, Normand J, Haider M, Ketela T, Wrana JL, Rottapel R, Neel BG, Moffat J. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discov. 2012 Feb;2(2):172-89. Epub 2011 Dec 29. PubMed PMID: 22585861.

Guerra FM, Gommerman JL, Corfe SA, Paige CJ, Rottapel R. Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. PLoS One. 2012;7(4):e35533. Epub 2012 Apr 24. PubMed PMID: 22545114; PubMed Central PMCID: PMC3335840.

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2011

Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R, Sicheri F. Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell. 2011 Dec 9;147(6):1340-54. Erratum in: Cell. 2012 Jan 20;148(1-2):376. PubMed PMID: 22153077.

Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M, Krzyzanowski PM, Scotter A, Gu S, Janmohamed S, Cong F, Simoncic PD, Ueki Y, La Rose J, Rottapel R. Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell. 2011 Dec 9;147(6):1324-39. PubMed PMID: 22153076.

Corfe SA, Rottapel R, Paige CJ. Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells. J Immunol. 2011 Oct 1;187(7):3499-510. Epub 2011 Aug 26. PubMed PMID: 21873521.

Levaot N, Simoncic PD, Dimitriou ID, Scotter A, La Rose J, Ng AH, Willett TL, Wang CJ, Janmohamed S, Grynpas M, Reichenberger E, Rottapel R. 3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions. J Clin Invest. 2011 Aug;121(8):3244-57. doi: 10.1172/JCI45843. Epub 2011 Jul 18. PubMed PMID: 21765218; PubMed Central PMCID: PMC3148735.

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2010

GuezGuez A, Prod'homme V, Mouska X, Baudot A, Blin-Wakkach C, Rottapel R, Deckert M. 3BP2 Adapter protein is required for receptor activator of NFkappaB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells. J Biol Chem. 2010 Jul 2;285(27):20952-63. Epub 2010 May 3. PubMed PMID: 20439986; PubMed Central PMCID: PMC2898328.

Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S. Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. J Immunol. 2010 Jul 1;185(1):357-66. Epub 2010 Jun 2. PubMed PMID: 20519645.

Jain P, Coisne C, Enzmann G, Rottapel R, Engelhardt B. Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis. J Immunol. 2010 Jun 15;184(12):7196-206. Epub 2010 May 17. PubMed PMID: 20483748.

Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD. The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 2010 Jun 10;115(23):4824-33. Epub 2010 Mar 26. PubMed PMID: 20348394.

Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, Pujana MA. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle. 2010 Mar 15;9(6):1143-55. Epub 2010 Mar 15. PubMed PMID: 20237422.

Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M. Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics. J Biol Chem. 2010 Feb 19;285(8):5132-6. Epub 2009 Dec 14. PubMed PMID: 20018863; PubMed Central PMCID: PMC2820739.

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2009

Meiri D, Greeve MA, Brunet A, Finan D, Wells CD, LaRose J, Rottapel R. Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation. Mol Cell Biol. 2009 Nov;29(21):5963-73. Epub 2009 Aug 10. PubMed PMID: 19667072; PubMed Central PMCID: PMC2772734.

Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nat Neurosci. 2009 Jun;12(6):735-44. Epub 2009 May 17. PubMed PMID: 19448628.

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2008

Dimitriou ID, Clemenza L, Scotter AJ, Chen G, Guerra FM, Rottapel R. Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunol Rev. 2008 Aug;224:265-83. Review. PubMed PMID: 18759933.

Garçon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K. CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood. 2008 Feb 1;111(3):1464-71. Epub 2007 Nov 15. PubMed PMID: 18006698.

Dehlin M, Bokarewa M, Rottapel R, Foster SJ, Magnusson M, Dahlberg LE, Tarkowski A. Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis. PLoS One. 2008;3(11):e3633. Epub 2008 Nov 4. PubMed PMID: 18982072; PubMed Central PMCID: PMC2575855.

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2007

Chen G, Dimitriou ID, La Rose J, Ilangumaran S, Yeh WC, Doody G, Turner M, Gommerman J, Rottapel R. The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Mol Cell Biol. 2007 Apr;27(8):3109-22. Epub 2007 Feb 5. PubMed PMID: 17283041; PubMed Central PMCID: PMC1899947.

Lam QL, Lo CK, Zheng BJ, Ko KH, Osmond DG, Wu GE, Rottapel R, Lu L. Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice. Int Immunol. 2007 Mar;19(3):267-76. Epub 2007 Jan 17. PubMed PMID: 17229817.

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2006

Ramanathan S, Gagnon J, Leblanc C, Rottapel R, Ilangumaran S. Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. J Immunol. 2006 Apr 1;176(7):4029-41. PubMed PMID: 16547238.

Deckert M, Rottapel R. The adapter 3BP2: how it plugs into leukocyte signaling. Adv Exp Med Biol. 2006;584:107-14. Review. PubMed PMID: 16802602.

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2005

Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW. Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Res. 2005 Aug 1;65(15):6685-91. PubMed PMID: 16061649.

Bakal CJ, Finan D, LaRose J, Wells CD, Gish G, Kulkarni S, DeSepulveda P, Wilde A, Rottapel R. The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9529-34. Epub 2005 Jun 23. PubMed PMID: 15976019; PubMed Central PMCID: PMC1157106.

Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, Gray MW, Harrington LA, Hieter PA, Johnston G, Kelvin DJ, McCarry BE, Michnick SW, Ouellette F, Pearlman RE, Penn LJ, Pelletier J, Rachubinski RA, Rennie PS, Rotin D, Rottapel R, Sadowski I, Sicheri F, Siminovitch L, Sonenberg N, Siu KW, Tremblay ML, Winegarden N, Wozniak RW, Wright GD, Woodgett JR. Problems with co-funding in Canada. Science. 2005 Jun 24;308(5730):1867. PubMed PMID: 15976286.

Wu LX, La Rose J, Chen L, Neale C, Mak T, Okkenhaug K, Wange R, Rottapel R. CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway. J Immunol. 2005 Jan 1;174(1):180-94. PubMed PMID: 15611240.

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2004

Ilangumaran S, Ramanathan S, Rottapel R. Regulation of the immune system by SOCS family adaptor proteins. Semin Immunol. 2004 Dec;16(6):351-65. Review. PubMed PMID: 15541651.

Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med. 2004 Nov 1;200(9):1167-77. PubMed PMID: 15520247; PubMed Central PMCID: PMC2211862.

Utting O, Sedgmen BJ, Watts TH, Shi X, Rottapel R, Iulianella A, Lohnes D, Veillette A. Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Mol Cell Biol. 2004 Jul;24(13):6067-75. PubMed PMID: 15199160; PubMed Central PMCID: PMC480883.

Minoo P, Zadeh MM, Rottapel R, Lebrun JJ, Ali S. A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling. Blood. 2004 Feb 15;103(4):1398-407. Epub 2003 Oct 9. PubMed PMID: 14551136.

Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med. 2004 Feb 2;199(3):399-410. PubMed PMID: 14757745; PubMed Central PMCID: PMC2211792.

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2003

Ilangumaran S, Ramanathan S, Ning T, La Rose J, Reinhart B, Poussier P, Rottapel R. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood. 2003 Dec 1;102(12):4115-22. Epub 2003 Aug 7. PubMed PMID: 12907450.

Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003 Dec;12(6):1413-26. PubMed PMID: 14690596.

Ilangumaran S, Finan D, Raine J, Rottapel R. Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease. J Biol Chem. 2003 Oct 24;278(43):41871-80. Epub 2003 Aug 12. PubMed PMID: 12917417.

Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative regulation of Vav. J Biol Chem. 2003 Oct 3;278(40):38495-504. Epub 2003 Jul 24. PubMed PMID: 12881521.

Ilangumaran S, Ramanathan S, La Rose J, Poussier P, Rottapel R. Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes. J Immunol. 2003 Sep 1;171(5):2435-45. PubMed PMID: 12928391.

Casteran N, De Sepulveda P, Beslu N, Aoubala M, Letard S, Lecocq E, Rottapel R, Dubreuil P. Signal transduction by several KIT juxtamembrane domain mutations. Oncogene. 2003 Jul 24;22(30):4710-22. PubMed PMID: 12879016.

Ilangumaran S, Finan D, Rottapel R. Flow cytometric analysis of cytokine receptor signal transduction. J Immunol Methods. 2003 Jul;278(1-2):221-34. PubMed PMID: 12957410.

Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, Penninger JM. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 2003 Jun;18(6):763-75. PubMed PMID: 12818158.

Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol Cell Biol. 2003 May;23(9):3067-78. PubMed PMID: 12697809; PubMed Central PMCID: PMC153186.

Ilangumaran S, Rottapel R. Regulation of cytokine receptor signaling by SOCS1. Immunol Rev. 2003 Apr;192:196-211. Review. PubMed PMID: 12670405.

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2002

Ilangumaran S, Finan D, La Rose J, Raine J, Silverstein A, De Sepulveda P, Rottapel R. A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts. J Immunol. 2002 Nov 1;169(9):5010-20. PubMed PMID: 12391216.

Haq R, Brenton JD, Takahashi M, Finan D, Finkielsztein A, Damaraju S, Rottapel R, Zanke B. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res. 2002 Sep 1;62(17):5076-82. Erratum in: Cancer Res 2002 Dec 15;62(24):7380. PubMed PMID: 12208764.

Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel R, Woodgett JR, Ohashi PS. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J Exp Med. 2002 Aug 5;196(3):335-48. PubMed PMID: 12163562; PubMed Central PMCID: PMC2193932.

Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D, Dubreuil P, de Sepulveda P. The tumor suppressor activity of SOCS-1. Oncogene. 2002 Jun 27;21(28):4351-62. PubMed PMID: 12080466.

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2001

Rottapel R. Putting the brakes on arthritis: can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis? J Clin Invest. 2001 Dec;108(12):1745-7. PubMed PMID: 11748257; PubMed Central PMCID: PMC209478.

Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G. Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal. J Biol Chem. 2001 Jun 22;276(25):22133-9. Epub 2001 Apr 10. PubMed PMID: 11297560.

Trop S, De Sepulveda P, Zúñiga-Pflücker JC, Rottapel R. Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes. Blood. 2001 Apr 15;97(8):2269-77. PubMed PMID: 11290587.

Okkenhaug K, Wu L, Garza KM, La Rose J, Khoo W, Odermatt B, Mak TW, Ohashi PS, Rottapel R. A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat Immunol. 2001 Apr;2(4):325-32. PubMed PMID: 11276203.

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2000

De Sepulveda P, Ilangumaran S, Rottapel R. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. J Biol Chem. 2000 May 12;275(19):14005-8. PubMed PMID: 10747851.

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1999

Tyers M, Rottapel R. VHL: a very hip ligase. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12230-2. PubMed PMID: 10535903; PubMed Central PMCID: PMC34256.

Leung BL, Haughn L, Veillette A, Hawley RG, Rottapel R, Julius M. TCR alpha beta-independent CD28 signaling and costimulation require non-CD4-associated Lck. J Immunol. 1999 Aug 1;163(3):1334-41. PubMed PMID: 10415032.

De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 1999 Feb 15;18(4):904-15. PubMed PMID: 10022833; PubMed Central PMCID: PMC1171183.

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1998

Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity. 1998 Nov;9(5):595-605. PubMed PMID: 9846481.

Okkenhaug K, Rottapel R. Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction. J Biol Chem. 1998 Aug 14;273(33):21194-202. PubMed PMID: 9694876.

Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol. 1998 Apr;18(4):2089-99. PubMed PMID: 9528781; PubMed Central PMCID: PMC121439.

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1997

Gommerman JL, Rottapel R, Berger SA. Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor. J Biol Chem. 1997 Nov 28;272(48):30519-25. PubMed PMID: 9374546.

Marengère LE, Okkenhaug K, Clavreul A, Couez D, Gibson S, Mills GB, Mak TW, Rottapel R. The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28. J Immunol. 1997 Oct 1;159(7):3220-9. Erratum in: J Immunol 1999 Jul 15;163(2):1092. PubMed PMID: 9317120.

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1996

Beslu N, LaRose J, Casteran N, Birnbaum D, Lecocq E, Dubreuil P, Rottapel R. Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase. J Biol Chem. 1996 Aug 16;271(33):20075-81. PubMed PMID: 8702727.

Ray RJ, Paige CJ, Furlonger C, Lyman SD, Rottapel R. Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7. Eur J Immunol. 1996 Jul;26(7):1504-10. PubMed PMID: 8766553.

Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP. Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase. J Biol Chem. 1996 May 31;271(22):12956-63. PubMed PMID: 8662748.

Rosnet O, Bühring HJ, deLapeyrière O, Beslu N, Lavagna C, Marchetto S, Rappold I, Drexler HG, Birg F, Rottapel R, Hannum C, Dubreuil P, Birnbaum D. Expression and signal transduction of the FLT3 tyrosine kinase receptor. Acta Haematol. 1996;95(3-4):218-23. PubMed PMID: 8677746.

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1995

deLapeyrière O, Naquet P, Planche J, Marchetto S, Rottapel R, Gambarelli D, Rosnet O, Birnbaum D. Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues. Differentiation. 1995 Jun;58(5):351-9. PubMed PMID: 7622010.

Borg JP, deLapeyrière O, Noguchi T, Rottapel R, Dubreuil P, Birnbaum D. Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase. Oncogene. 1995 Mar 2;10(5):973-84. PubMed PMID: 7898938.

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1994

Rottapel R, Turck CW, Casteran N, Liu X, Birnbaum D, Pawson T, Dubreuil P. Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase. Oncogene. 1994 Jun;9(6):1755-65. PubMed PMID: 8183574.

Pagès F, Ragueneau M, Rottapel R, Truneh A, Nunes J, Imbert J, Olive D. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling. Nature. 1994 May 26;369(6478):327-9. Erratum in: Nature 1994 Jul 14;370(6485):157. PubMed PMID: 8183372.

Casteran N, Rottapel R, Beslu N, Lecocq E, Birnbaum D, Dubreuil P. Analysis of the mitogenic pathway of the FLT3 receptor and characterization in its C terminal region of a specific binding site for the PI3' kinase. Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):443-56. PubMed PMID: 7920189.

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1993

Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D. The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor. Oncogene. 1993 May;8(5):1233-40. PubMed PMID: 8386825.

Maroc N, Rottapel R, Rosnet O, Marchetto S, Lavezzi C, Mannoni P, Birnbaum D, Dubreuil P. Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase. Oncogene. 1993 Apr;8(4):909-18. PubMed PMID: 8384358.

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1992

Rottapel R. The fascinating story of a longstanding puzzle revealed or what we can learn from a mouse. J Rheumatol. 1992 Oct;19(10):1498-501. PubMed PMID: 1464858.

Meininger CJ, Yano H, Rottapel R, Bernstein A, Zsebo KM, Zetter BR. The c-kit receptor ligand functions as a mast cell chemoattractant. Blood. 1992 Feb 15;79(4):958-63. PubMed PMID: 1371080.

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1991

Rottapel R, Reedijk M, Williams DE, Lyman SD, Anderson DM, Pawson T, Bernstein A. The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol. 1991 Jun;11(6):3043-51. PubMed PMID: 1710023; PubMed Central PMCID: PMC360141.

Bernstein A, Forrester L, Reith AD, Dubreuil P, Rottapel R. The murine W/c-kit and Steel loci and the control of hematopoiesis. Semin Hematol. 1991 Apr;28(2):138-42. Review. PubMed PMID: 1715096.

Dubreuil P, Forrester L, Rottapel R, Reedijk M, Fujita J, Bernstein A. The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2341-5. PubMed PMID: 1826051; PubMed Central PMCID: PMC51227.

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1990

Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev. 1990 Mar;4(3):390-400. PubMed PMID: 1692559.

Dubreuil P, Rottapel R, Reith AD, Forrester L, Bernstein A. The mouse W/c-kit locus. A mammalian gene that controls the development of three distinct cell lineages. Ann N Y Acad Sci. 1990;599:58-65. PubMed PMID: 1699461.

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