PUBLICATIONS
2018
Gebregiworgis T, Marshall CB, Nishikawa T, Radulovich N, Sandí MJ, Fang Z, Rottapel R, Tsao MS, Ikura M. Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids. J Am Chem Soc. 2018 Apr 4;140(13):4473-4476. doi: 10.1021/jacs.7b13703. PubMed PMID: 29543440.
2017
Fine N, Dimitriou ID, Rottapel R. Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils. Small GTPases. 2017 Nov 30:1-9. doi: 10.1080/21541248.2017.1332505. PubMed PMID: 29188751.
Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R. MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity. Sci Signal. 2017 Oct 31;10(503). pii: eaan3286. doi:10.1126/scisignal.aan3286. PubMed PMID: 29089450.
Kent OA, Sandi MJ, Rottapel R. Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition. J Clin Invest. Small GTPases. 2017 Jun 28:1-8. doi: 10.1080/21541248.2017.1337545. PubMed PMID: 28656876.
Matsumoto Y, La Rose J, Lim M, Adissu HA, Law N, Mao X, Cong F, Mera P, Karsenty G, Goltzman D, Changoor A, Zhang L, Stajkowski M, Grynpas MD, Bergmann C, Rottapel R. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. J Clin Invest. 2017 Jun 30;127(7):2612-2625. doi: 10.1172/JCI92233. PubMed PMID: 28581440.
Matsumoto Y, Larose J, Kent OA, Lim M, Changoor A, Zhang L, Storozhuk Y, Mao X, Grynpas MD, Cong F, Rottapel R. RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146. J Clin Invest. 2017 Apr 3;127(4):1303-1315. doi: 10.1172/JCI90527. PubMed PMID: 28287403.
Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, Novikov I, Huertas P, Rottapel R, Sood AK, Izraeli S. Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer. Oncotarget. 2017 Mar 10:27380-27392. doi: 10.18632/oncotarget.16068. PubMed PMID: 28423708.
Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R. Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer. Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028. PubMed PMID: 28273451.
Kent OA, Sandí MJ, Burston HE, Brown KR, Rottapel R. An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.Oncotarget. 2017 Jan 17;8(3):4484-4500. doi: 10.18632/oncotarget.13152. PubMed PMID: 27835861
2016
Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. PubMed PMID: 27797343.
Fine N, Dimitriou ID, Rullo J, Sandí MJ, Petri B, Haitsma J, Ibrahim H, La Rose J, Glogauer M, Kubes P, Cybulsky M, Rottapel
R. GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.J Cell Biol. 2016 Oct 10;215(1):107-119. doi: 10.1083/jcb.201603109. PubMed PMID: 27738004.
Kent OA, Mendell JT, Rottapel R. Transcriptional Regulation of miR-31 by
Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1. Mol Cancer
Res. 2016 Mar;14(3):267-77. doi: 10.1158/1541-7786.MCR-15-0456. Epub 2016 Jan 8.
PubMed PMID: 26747707
2015
Prod'Homme V, Boyer L, Dubois N, Mallavialle A, Munro P, Mouska X, Coste I,
Rottapel R, Tartare-Deckert S, Deckert M. Cherubism allele heterozygosity
amplifies microbe-induced inflammatory responses in murine macrophages. J Clin
Invest. 2015 Apr;125(4):1396-400. doi: 10.1172/JCI71081. Epub 2015 Feb 23. PubMed
PMID: 25705883; PubMed Central PMCID: PMC4396483.
Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y,
Nishida K, Rottapel R, Ueki Y. Loss of SH3 domain-binding protein 2 function
suppresses bone destruction in tumor necrosis factor-driven and collagen-induced
arthritis in mice. Arthritis Rheumatol. 2015 Mar;67(3):656-67. doi:
10.1002/art.38975. PubMed PMID: 25470448; PubMed Central PMCID: PMC4342302.
2014
Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL,
Rottapel R, Brotto M, Reichenberger EJ, Ueki Y. SH3BP2 cherubism mutation
potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated
inflammatory bone loss. J Bone Miner Res. 2014 Dec;29(12):2618-35. doi:
10.1002/jbmr.2295. PubMed PMID: 24916406
Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J,
Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY. Insights
into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr D Biol Crystallogr. 2014 Oct 1;70(Pt 10):2740-53. doi:
10.1107/S1399004714017660. Epub 2014 Sep 27. PubMed PMID: 25286857.
Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M,
Rottapel R. Mechanistic insight into GPCR-mediated activation of the
microtubule-associated RhoA exchange factor GEF-H1. Nat Commun. 2014 Sep
11;5:4857. doi: 10.1038/ncomms5857. PubMed PMID: 25209408.
Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J. Measuring error rates in
genomic perturbation screens: gold standards for human functional genomics. Mol
Syst Biol. 2014 Jul 1;10(7):733. doi: 10.15252/msb.20145216. PubMed PMID:
24987113.
Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL,
Rottapel R, Brotto M, Reichenberger EJ, Ueki Y. SH3BP2 Cherubism Mutation
Potentiates TNF-α-Induced Osteoclastogenesis Via NFATc1 and TNF-α-Mediated
Inflammatory Bone Loss. J Bone Miner Res. 2014 Jun 10. doi: 10.1002/jbmr.2295.
[Epub ahead of print] PubMed PMID: 24916406.
Cullis J, Meiri D, Sandi MJ, Radulovich N, Kent OA, Medrano M, Mokady D,
Normand J, Larose J, Marcotte R, Marshall CB, Ikura M, Ketela T, Moffat J, Neel
BG, Gingras AC, Tsao MS, Rottapel R. The RhoGEF GEF-H1 Is Required for Oncogenic
RAS Signaling via KSR-1. Cancer Cell. 2014 Feb 10;25(2):181-95. doi:
10.1016/j.ccr.2014.01.025. PubMed PMID: 24525234.
Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z,
Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. shRNA
kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.
Cancer Res. 2014 Jan 31. PubMed PMID: 24487029.
2013
Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young
JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB,
Fedyshyn Y, Wang Y, Brito GC, Kasimer D, Makhnevych T, Ketela T, Datti A, Babu M,
Emili A, Pelletier L, Wrana J, Wainberg Z, Kim PM, Rottapel R, O'Brien CA,
Andrews B, Boone C, Moffat J. A negative genetic interaction map in isogenic
cancer cell lines reveals cancer cell vulnerabilities. Mol Syst Biol. 2013 Oct
8;9:696. doi: 10.1038/msb.2013.54. PubMed PMID: 24104479; PubMed Central PMCID:
PMC3817404.
2012
Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P,
Rottapel R. The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated
Neutrophil Activation. J Immunol. 2012 Jul 18. [Epub ahead of print] PubMed PMID:
22815290.
Borozan I, Wilson S, Blanchette P, Laflamme P, Watt SN, Krzyzanowski PM,
Sircoulomb F, Rottapel R, Branton PE, Ferretti V. CaPSID: a bioinformatics
platform for computational pathogen sequence identification in human genomes and
transcriptomes. BMC Bioinformatics. 2012 Aug 17;13:206. doi:
10.1186/1471-2105-13-206. PubMed PMID: 22901030; PubMed Central PMCID:
PMC3464663.
Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel
R, Stambolic V, Ikura M. Probing the GTPase cycle with real-time NMR: GAP and GEF
activities in cell extracts. Methods. 2012 Jun 28. [Epub ahead of print] PubMed
PMID: 22750304.
Meiri D, Marshall CB, Greeve MA, Kim B, Balan M, Suarez F, Bakal C, Wu C,
Larose J, Fine N, Ikura M, Rottapel R. Mechanistic insight into the microtubule
and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition. Mol
Cell. 2012 Mar 9;45(5):642-55. Erratum in: Mol Cell. 2012 Mar 30;45(6):844.
Bakal, Chris [added]. PubMed PMID: 22405273.
Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM,
Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M,
Brito GC, Vizeacoumar FJ, Vizeacoumar FS, Datti A, Kasimer D, Buzina A, Mero P,
Misquitta C, Normand J, Haider M, Ketela T, Wrana JL, Rottapel R, Neel BG, Moffat
J. Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2012 Feb;2(2):172-89. Epub 2011 Dec 29. PubMed PMID: 22585861.
Guerra FM, Gommerman JL, Corfe SA, Paige CJ, Rottapel R.
Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell
homeostasis and optimal T-independent type 2 humoral response. PLoS One.
2012;7(4):e35533. Epub 2012 Apr 24. PubMed PMID: 22545114; PubMed Central PMCID:
PMC3335840.
2011
Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R,
Sicheri F. Structural basis and sequence rules for substrate recognition by
Tankyrase explain the basis for cherubism disease. Cell. 2011 Dec
9;147(6):1340-54. Erratum in: Cell. 2012 Jan 20;148(1-2):376. PubMed PMID:
22153077.
Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M,
Krzyzanowski PM, Scotter A, Gu S, Janmohamed S, Cong F, Simoncic PD, Ueki Y, La
Rose J, Rottapel R. Loss of Tankyrase-mediated destruction of 3BP2 is the
underlying pathogenic mechanism of cherubism. Cell. 2011 Dec 9;147(6):1324-39.
PubMed PMID: 22153076.
Corfe SA, Rottapel R, Paige CJ. Modulation of IL-7 thresholds by SOCS proteins
in developing B lineage cells. J Immunol. 2011 Oct 1;187(7):3499-510. Epub 2011
Aug 26. PubMed PMID: 21873521.
Levaot N, Simoncic PD, Dimitriou ID, Scotter A, La Rose J, Ng AH, Willett TL,
Wang CJ, Janmohamed S, Grynpas M, Reichenberger E, Rottapel R. 3BP2-deficient
mice are osteoporotic with impaired osteoblast and osteoclast functions. J Clin
Invest. 2011 Aug;121(8):3244-57. doi: 10.1172/JCI45843. Epub 2011 Jul 18. PubMed
PMID: 21765218; PubMed Central PMCID: PMC3148735.
2010
GuezGuez A, Prod'homme V, Mouska X, Baudot A, Blin-Wakkach C, Rottapel R,
Deckert M. 3BP2 Adapter protein is required for receptor activator of NFkappaB
ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells. J Biol Chem.
2010 Jul 2;285(27):20952-63. Epub 2010 May 3. PubMed PMID: 20439986; PubMed
Central PMCID: PMC2898328.
Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G,
Rottapel R, Ohashi PS, Ilangumaran S. Regulation of cytokine-driven functional
differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls
autoimmunity and preserves their proliferative capacity toward foreign antigens.
J Immunol. 2010 Jul 1;185(1):357-66. Epub 2010 Jun 2. PubMed PMID: 20519645.
Jain P, Coisne C, Enzmann G, Rottapel R, Engelhardt B. Alpha4beta1 integrin
mediates the recruitment of immature dendritic cells across the blood-brain
barrier during experimental autoimmune encephalomyelitis. J Immunol. 2010 Jun
15;184(12):7196-206. Epub 2010 May 17. PubMed PMID: 20483748.
Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J,
Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R,
Schimmer AD. The antihelmintic flubendazole inhibits microtubule function through
a mechanism distinct from Vinca alkaloids and displays preclinical activity in
leukemia and myeloma. Blood. 2010 Jun 10;115(23):4824-33. Epub 2010 Mar 26.
PubMed PMID: 20348394.
Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO,
Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M,
Astrinidis A, Piekorz RP, Pujana MA. TACC3-TSC2 maintains nuclear envelope
structure and controls cell division. Cell Cycle. 2010 Mar 15;9(6):1143-55. Epub
2010 Mar 15. PubMed PMID: 20237422.
Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V,
Rottapel R, Neel BG, Ikura M. Real-time NMR study of three small GTPases reveals
that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter
hydrolysis and exchange kinetics. J Biol Chem. 2010 Feb 19;285(8):5132-6. Epub
2009 Dec 14. PubMed PMID: 20018863; PubMed Central PMCID: PMC2820739.
2009
Meiri D, Greeve MA, Brunet A, Finan D, Wells CD, LaRose J, Rottapel R.
Modulation of Rho guanine exchange factor Lfc activity by protein kinase
A-mediated phosphorylation. Mol Cell Biol. 2009 Nov;29(21):5963-73. Epub 2009 Aug
10. PubMed PMID: 19667072; PubMed Central PMCID: PMC2772734.
Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Lfc
and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Nat
Neurosci. 2009 Jun;12(6):735-44. Epub 2009 May 17. PubMed PMID: 19448628.
2008
Dimitriou ID, Clemenza L, Scotter AJ, Chen G, Guerra FM, Rottapel R. Putting
out the fire: coordinated suppression of the innate and adaptive immune systems
by SOCS1 and SOCS3 proteins. Immunol Rev. 2008 Aug;224:265-83. Review. PubMed
PMID: 18759933.
Garçon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K.
CD28 provides T-cell costimulation and enhances PI3K activity at the immune
synapse independently of its capacity to interact with the p85/p110 heterodimer.
Blood. 2008 Feb 1;111(3):1464-71. Epub 2007 Nov 15. PubMed PMID: 18006698.
Dehlin M, Bokarewa M, Rottapel R, Foster SJ, Magnusson M, Dahlberg LE,
Tarkowski A. Intra-articular fms-like tyrosine kinase 3 ligand expression is a
driving force in induction and progression of arthritis. PLoS One.
2008;3(11):e3633. Epub 2008 Nov 4. PubMed PMID: 18982072; PubMed Central PMCID:
PMC2575855.
2007
Chen G, Dimitriou ID, La Rose J, Ilangumaran S, Yeh WC, Doody G, Turner M,
Gommerman J, Rottapel R. The 3BP2 adapter protein is required for optimal B-cell
activation and thymus-independent type 2 humoral response. Mol Cell Biol. 2007
Apr;27(8):3109-22. Epub 2007 Feb 5. PubMed PMID: 17283041; PubMed Central PMCID:
PMC1899947.
Lam QL, Lo CK, Zheng BJ, Ko KH, Osmond DG, Wu GE, Rottapel R, Lu L. Impaired
V(D)J recombination and increased apoptosis among B cell precursors in the bone
marrow of c-Abl-deficient mice. Int Immunol. 2007 Mar;19(3):267-76. Epub 2007 Jan
17. PubMed PMID: 17229817.
2006
Ramanathan S, Gagnon J, Leblanc C, Rottapel R, Ilangumaran S. Suppressor of
cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15
in vivo during T lymphocyte development and homeostasis. J Immunol. 2006 Apr
1;176(7):4029-41. PubMed PMID: 16547238.
Deckert M, Rottapel R. The adapter 3BP2: how it plugs into leukocyte
signaling. Adv Exp Med Biol. 2006;584:107-14. Review. PubMed PMID: 16802602.
2005
Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg
K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S,
Mak TW. Ckap2 regulates aneuploidy, cell cycling, and cell death in a
p53-dependent manner. Cancer Res. 2005 Aug 1;65(15):6685-91. PubMed PMID:
16061649.
Bakal CJ, Finan D, LaRose J, Wells CD, Gish G, Kulkarni S, DeSepulveda P,
Wilde A, Rottapel R. The Rho GTP exchange factor Lfc promotes spindle assembly in
early mitosis. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9529-34. Epub 2005
Jun 23. PubMed PMID: 15976019; PubMed Central PMCID: PMC1157106.
Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA,
Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ,
Golding GB, Gray MW, Harrington LA, Hieter PA, Johnston G, Kelvin DJ, McCarry BE,
Michnick SW, Ouellette F, Pearlman RE, Penn LJ, Pelletier J, Rachubinski RA,
Rennie PS, Rotin D, Rottapel R, Sadowski I, Sicheri F, Siminovitch L, Sonenberg
N, Siu KW, Tremblay ML, Winegarden N, Wozniak RW, Wright GD, Woodgett JR.
Problems with co-funding in Canada. Science. 2005 Jun 24;308(5730):1867. PubMed
PMID: 15976286.
Wu LX, La Rose J, Chen L, Neale C, Mak T, Okkenhaug K, Wange R, Rottapel R.
CD28 regulates the translation of Bcl-xL via the phosphatidylinositol
3-kinase/mammalian target of rapamycin pathway. J Immunol. 2005 Jan
1;174(1):180-94. PubMed PMID: 15611240.
2004
Ilangumaran S, Ramanathan S, Rottapel R. Regulation of the immune system by
SOCS family adaptor proteins. Semin Immunol. 2004 Dec;16(6):351-65. Review.
PubMed PMID: 15541651.
Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The
molecular adapter Carma1 controls entry of IkappaB kinase into the central immune
synapse. J Exp Med. 2004 Nov 1;200(9):1167-77. PubMed PMID: 15520247; PubMed
Central PMCID: PMC2211862.
Utting O, Sedgmen BJ, Watts TH, Shi X, Rottapel R, Iulianella A, Lohnes D,
Veillette A. Immune functions in mice lacking Clnk, an SLP-76-related adaptor
expressed in a subset of immune cells. Mol Cell Biol. 2004 Jul;24(13):6067-75.
PubMed PMID: 15199160; PubMed Central PMCID: PMC480883.
Minoo P, Zadeh MM, Rottapel R, Lebrun JJ, Ali S. A novel SHP-1/Grb2-dependent
mechanism of negative regulation of cytokine-receptor signaling: contribution of
SHP-1 C-terminal tyrosines in cytokine signaling. Blood. 2004 Feb
15;103(4):1398-407. Epub 2003 Oct 9. PubMed PMID: 14551136.
Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani
M, Rottapel R, Zúñiga-Pflücker JC, Mak TW. Survivin loss in thymocytes triggers
p53-mediated growth arrest and p53-independent cell death. J Exp Med. 2004 Feb
2;199(3):399-410. PubMed PMID: 14757745; PubMed Central PMCID: PMC2211792.
2003
Ilangumaran S, Ramanathan S, Ning T, La Rose J, Reinhart B, Poussier P,
Rottapel R. Suppressor of cytokine signaling 1 attenuates IL-15 receptor
signaling in CD8+ thymocytes. Blood. 2003 Dec 1;102(12):4115-22. Epub 2003 Aug 7.
PubMed PMID: 12907450.
Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S,
Lu KP. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization
and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003 Dec;12(6):1413-26.
PubMed PMID: 14690596.
Ilangumaran S, Finan D, Raine J, Rottapel R. Suppressor of cytokine signaling
1 regulates an endogenous inhibitor of a mast cell protease. J Biol Chem. 2003
Oct 24;278(43):41871-80. Epub 2003 Aug 12. PubMed PMID: 12917417.
Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ,
Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative
regulation of Vav. J Biol Chem. 2003 Oct 3;278(40):38495-504. Epub 2003 Jul 24.
PubMed PMID: 12881521.
Ilangumaran S, Ramanathan S, La Rose J, Poussier P, Rottapel R. Suppressor of
cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T
lymphocytes. J Immunol. 2003 Sep 1;171(5):2435-45. PubMed PMID: 12928391.
Casteran N, De Sepulveda P, Beslu N, Aoubala M, Letard S, Lecocq E, Rottapel
R, Dubreuil P. Signal transduction by several KIT juxtamembrane domain mutations.
Oncogene. 2003 Jul 24;22(30):4710-22. PubMed PMID: 12879016.
Ilangumaran S, Finan D, Rottapel R. Flow cytometric analysis of cytokine
receptor signal transduction. J Immunol Methods. 2003 Jul;278(1-2):221-34. PubMed
PMID: 12957410.
Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M,
Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G,
Rottapel R, Penninger JM. The MAGUK family protein CARD11 is essential for
lymphocyte activation. Immunity. 2003 Jun;18(6):763-75. PubMed PMID: 12818158.
Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. Autoinhibition
of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol
Cell Biol. 2003 May;23(9):3067-78. PubMed PMID: 12697809; PubMed Central PMCID:
PMC153186.
Ilangumaran S, Rottapel R. Regulation of cytokine receptor signaling by
SOCS1. Immunol Rev. 2003 Apr;192:196-211. Review. PubMed PMID: 12670405.
2002
Ilangumaran S, Finan D, La Rose J, Raine J, Silverstein A, De Sepulveda P,
Rottapel R. A positive regulatory role for suppressor of cytokine signaling 1 in
IFN-gamma-induced MHC class II expression in fibroblasts. J Immunol. 2002 Nov
1;169(9):5010-20. PubMed PMID: 12391216.
Haq R, Brenton JD, Takahashi M, Finan D, Finkielsztein A, Damaraju S,
Rottapel R, Zanke B. Constitutive p38HOG mitogen-activated protein kinase
activation induces permanent cell cycle arrest and senescence. Cancer Res. 2002
Sep 1;62(17):5076-82. Erratum in: Cancer Res 2002 Dec 15;62(24):7380. PubMed
PMID: 12208764.
Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel
R, Woodgett JR, Ohashi PS. CD28-dependent activation of protein kinase B/Akt
blocks Fas-mediated apoptosis by preventing death-inducing signaling complex
assembly. J Exp Med. 2002 Aug 5;196(3):335-48. PubMed PMID: 12163562; PubMed
Central PMCID: PMC2193932.
Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, Nguyen MH, Barber D,
Dubreuil P, de Sepulveda P. The tumor suppressor activity of SOCS-1. Oncogene.
2002 Jun 27;21(28):4351-62. PubMed PMID: 12080466.
2001
Rottapel R. Putting the brakes on arthritis: can suppressors of cytokine
signaling (SOCS) suppress rheumatoid arthritis? J Clin Invest. 2001
Dec;108(12):1745-7. PubMed PMID: 11748257; PubMed Central PMCID: PMC209478.
Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G.
Suppressor of cytokine signaling 1 interacts with the macrophage
colony-stimulating factor receptor and negatively regulates its proliferation
signal. J Biol Chem. 2001 Jun 22;276(25):22133-9. Epub 2001 Apr 10. PubMed PMID:
11297560.
Trop S, De Sepulveda P, Zúñiga-Pflücker JC, Rottapel R. Overexpression of
suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced
proliferation but not differentiation of immature thymocytes. Blood. 2001 Apr
15;97(8):2269-77. PubMed PMID: 11290587.
Okkenhaug K, Wu L, Garza KM, La Rose J, Khoo W, Odermatt B, Mak TW, Ohashi
PS, Rottapel R. A point mutation in CD28 distinguishes proliferative signals from
survival signals. Nat Immunol. 2001 Apr;2(4):325-32. PubMed PMID: 11276203.
2000
De Sepulveda P, Ilangumaran S, Rottapel R. Suppressor of cytokine signaling-1
inhibits VAV function through protein degradation. J Biol Chem. 2000 May
12;275(19):14005-8. PubMed PMID: 10747851.
1999
Tyers M, Rottapel R. VHL: a very hip ligase. Proc Natl Acad Sci U S A. 1999
Oct 26;96(22):12230-2. PubMed PMID: 10535903; PubMed Central PMCID: PMC34256.
Leung BL, Haughn L, Veillette A, Hawley RG, Rottapel R, Julius M. TCR alpha
beta-independent CD28 signaling and costimulation require non-CD4-associated Lck.
J Immunol. 1999 Aug 1;163(3):1334-41. PubMed PMID: 10415032.
De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R.
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent
proliferation. EMBO J. 1999 Feb 15;18(4):904-15. PubMed PMID: 10022833; PubMed
Central PMCID: PMC1171183.
1998
Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A. Adaptor
function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.
Immunity. 1998 Nov;9(5):595-605. PubMed PMID: 9846481.
Okkenhaug K, Rottapel R. Grb2 forms an inducible protein complex with CD28
through a Src homology 3 domain-proline interaction. J Biol Chem. 1998 Aug
14;273(33):21194-202. PubMed PMID: 9694876.
Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA. SHP-1 binds
and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in
the c-Kit juxtamembrane domain. Mol Cell Biol. 1998 Apr;18(4):2089-99. PubMed
PMID: 9528781; PubMed Central PMCID: PMC121439.
1997
Gommerman JL, Rottapel R, Berger SA. Phosphatidylinositol 3-kinase and Ca2+
influx dependence for ligand-stimulated internalization of the c-Kit receptor. J
Biol Chem. 1997 Nov 28;272(48):30519-25. PubMed PMID: 9374546.
Marengère LE, Okkenhaug K, Clavreul A, Couez D, Gibson S, Mills GB, Mak TW,
Rottapel R. The SH3 domain of Itk/Emt binds to proline-rich sequences in the
cytoplasmic domain of the T cell costimulatory receptor CD28. J Immunol. 1997 Oct
1;159(7):3220-9. Erratum in: J Immunol 1999 Jul 15;163(2):1092. PubMed PMID:
9317120.
1996
Beslu N, LaRose J, Casteran N, Birnbaum D, Lecocq E, Dubreuil P, Rottapel R.
Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization
of the Flt3/Flk2 receptor tyrosine kinase. J Biol Chem. 1996 Aug
16;271(33):20075-81. PubMed PMID: 8702727.
Ray RJ, Paige CJ, Furlonger C, Lyman SD, Rottapel R. Flt3 ligand supports the
differentiation of early B cell progenitors in the presence of interleukin-11 and
interleukin-7. Eur J Immunol. 1996 Jul;26(7):1504-10. PubMed PMID: 8766553.
Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum
D, Borg JP. Interaction with the phosphotyrosine binding domain/phosphotyrosine
interacting domain of SHC is required for the transforming activity of the
FLT4/VEGFR3 receptor tyrosine kinase. J Biol Chem. 1996 May 31;271(22):12956-63.
PubMed PMID: 8662748.
Rosnet O, Bühring HJ, deLapeyrière O, Beslu N, Lavagna C, Marchetto S,
Rappold I, Drexler HG, Birg F, Rottapel R, Hannum C, Dubreuil P, Birnbaum D.
Expression and signal transduction of the FLT3 tyrosine kinase receptor. Acta
Haematol. 1996;95(3-4):218-23. PubMed PMID: 8677746.
1995
deLapeyrière O, Naquet P, Planche J, Marchetto S, Rottapel R, Gambarelli D,
Rosnet O, Birnbaum D. Expression of Flt3 tyrosine kinase receptor gene in mouse
hematopoietic and nervous tissues. Differentiation. 1995 Jun;58(5):351-9. PubMed
PMID: 7622010.
Borg JP, deLapeyrière O, Noguchi T, Rottapel R, Dubreuil P, Birnbaum D.
Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related
tyrosine kinase. Oncogene. 1995 Mar 2;10(5):973-84. PubMed PMID: 7898938.
1994
Rottapel R, Turck CW, Casteran N, Liu X, Birnbaum D, Pawson T, Dubreuil P.
Substrate specificities and identification of a putative binding site for PI3K in
the carboxy tail of the murine Flt3 receptor tyrosine kinase. Oncogene. 1994
Jun;9(6):1755-65. PubMed PMID: 8183574.
Pagès F, Ragueneau M, Rottapel R, Truneh A, Nunes J, Imbert J, Olive D.
Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell
signalling. Nature. 1994 May 26;369(6478):327-9. Erratum in: Nature 1994 Jul
14;370(6485):157. PubMed PMID: 8183372.
Casteran N, Rottapel R, Beslu N, Lecocq E, Birnbaum D, Dubreuil P. Analysis
of the mitogenic pathway of the FLT3 receptor and characterization in its C
terminal region of a specific binding site for the PI3' kinase. Cell Mol Biol
(Noisy-le-grand). 1994 May;40(3):443-56. PubMed PMID: 7920189.
1993
Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P,
Rosnet O, Birnbaum D. The FLT4 gene encodes a transmembrane tyrosine kinase
related to the vascular endothelial growth factor receptor. Oncogene. 1993
May;8(5):1233-40. PubMed PMID: 8386825.
Maroc N, Rottapel R, Rosnet O, Marchetto S, Lavezzi C, Mannoni P, Birnbaum D,
Dubreuil P. Biochemical characterization and analysis of the transforming
potential of the FLT3/FLK2 receptor tyrosine kinase. Oncogene. 1993
Apr;8(4):909-18. PubMed PMID: 8384358.
1992
Rottapel R. The fascinating story of a longstanding puzzle revealed or what
we can learn from a mouse. J Rheumatol. 1992 Oct;19(10):1498-501. PubMed PMID:
1464858.
Meininger CJ, Yano H, Rottapel R, Bernstein A, Zsebo KM, Zetter BR. The c-kit
receptor ligand functions as a mast cell chemoattractant. Blood. 1992 Feb
15;79(4):958-63. PubMed PMID: 1371080.
1991
Rottapel R, Reedijk M, Williams DE, Lyman SD, Anderson DM, Pawson T,
Bernstein A. The Steel/W transduction pathway: kit autophosphorylation and its
association with a unique subset of cytoplasmic signaling proteins is induced by
the Steel factor. Mol Cell Biol. 1991 Jun;11(6):3043-51. PubMed PMID: 1710023;
PubMed Central PMCID: PMC360141.
Bernstein A, Forrester L, Reith AD, Dubreuil P, Rottapel R. The murine
W/c-kit and Steel loci and the control of hematopoiesis. Semin Hematol. 1991
Apr;28(2):138-42. Review. PubMed PMID: 1715096.
Dubreuil P, Forrester L, Rottapel R, Reedijk M, Fujita J, Bernstein A. The
c-fms gene complements the mitogenic defect in mast cells derived from mutant W
mice but not mi (microphthalmia) mice. Proc Natl Acad Sci U S A. 1991 Mar
15;88(6):2341-5. PubMed PMID: 1826051; PubMed Central PMCID: PMC51227.
1990
Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A. W mutant
mice with mild or severe developmental defects contain distinct point mutations
in the kinase domain of the c-kit receptor. Genes Dev. 1990 Mar;4(3):390-400.
PubMed PMID: 1692559.
Dubreuil P, Rottapel R, Reith AD, Forrester L, Bernstein A. The mouse W/c-kit
locus. A mammalian gene that controls the development of three distinct cell
lineages. Ann N Y Acad Sci. 1990;599:58-65. PubMed PMID: 1699461.