Publications

Muhanna, N., Cui, L., Chan, H., Burgess, L., Jin, C.S., MacDonald, T.D., Huynh, E., Wang, F., Chen, J., Irish, J.C. & Zheng, G.
Multimodal Image-Guided Surgical and Photodynamic Interventions in Head-and-Neck Cancer: From Primary Tumor to Metastatic Drainage.
Clin. Cancer Res., 2015
Cui, L., Tokarz, D., Cisek, R., Ng, K.K., Wang, F., Chen, J., Barzda, V. & Zheng, G.
Organized Aggregation of Porphyrins in Lipid Bilayer for Third Harmonic Generation Microscopy
Angew. Chem. Int. Ed., 2015
Ng K.K., & Zheng G.
Molecular Interactons in Organic Nanoparticles for Phototheranostic Applications
Chem. Rev., 2015.
Cui, L., Lin, Q., Jin, C.S., Jiang, W., Huang, H., Ding, L., Muhanna, N., Irish, J.C., Wang, F., Chen, J. & Zheng G.
A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics.
ACS Nano, 2015.
Huynh E., Leung B.Y.C, Helfield B.L., Shakiba M., Gandier J., Jin C.S., Master E.R., Wilson B.C., Goertz D.E. & Zheng G.
In Situ Conversion of Porphyrin Microbubbles to Nanoparticles for Multimodality Imaging
Nat. Nano., 2015.
Charron D.M., Chen J. & Zheng G.
Theranostic lipid nanoparticles for cancer medicine
Nanotechnology-based precision tools for the detection and treatment of cancer, 2015.
Ng KK, Takada M, Jin CC & Zheng G.
Self-Sensing Porphysomes for Fluorescence-Guided Photothermal Therapy
Bioconj. Chem., 2015.
Liu TW, Chen J, Burgess L, Wilson BC, Zheng G, Zhan L, Liu WK, & Ha BY.
Activation kinetics of zipper molecular beacons
J. Phys. Chem. B, 2015.
Huynh E. & Zheng G.
Organic Biophotonic Nanoparticles: Porphysomes and Beyond
IEEE Journal of Selected Topics in Quantum Electronics, 2014.
Huynh E. & Zheng G.
Porphysome Nanotechnology: A Paradigm Shift in Lipid-based Supramolecular Structures
NanoToday, 2014.
Huynh E., Jin C.S., Wilson B.C. & Zheng G.
Aggregate Enhanced Trimodal Porphyrin Shell Microbubbles for Ultrasound, Photoacoustic and Fluorescence Imaging
Bioconjugate Chemistry, 2014.
Huang H., Cruz W., Chen J. & Zheng G.
Learning from Biology: Synthetic Lipoproteins for Drug Delivery
Wiley Interdiscip Rev. Nanomed. Nanobiotechnol., 2014.
Ng K.K., Shakiba M., Huynh E., Weersink R., Roxin A., Wilson B.C. & Zheng G.
Stimuli-Responsive Photoacoustic Nanoswitch for In Vivo Sensing Applications
ACS Nano, 2014.
Macdonald T.D., Liu T.W., & Zheng G.
An MRI-Sensitive, Non-Photobleachable Porphysome Photothermal Agent
Angewandte Chemie, Int. Ed., 2014.
Lin Q., Jin C.S., Huang H., Ding L., Chen J. & Zheng G.
Nanoparticle-Enabled, Image-Guided Treatment Planning of Target Specific RNAi Therapeutics in an Orthotopic Prostate Cancer Model
Small, 2014.
Huynh E., Lovell J.F., Fobel R. & Zheng G.
Optically Controlled Pore Formation in Self-sealing Giant Porphyrin Vesicles
Small, 2014.
Roxin A., Chen J., Paton A.S., Bender T.P. & Zheng G.
Reactive Oxygen Species Photogeneration of Bacteriopheophorbide a Derivatives by Exocyclic E-Ring Opening and Charge Modifications
Journal of Medicinal Chemistry, 2013.
Jin C.S., Lovell J.F. & Zheng G.
One Minute, Sub-one-watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles.
Journal of Visualized Experiments, 2013.
Lin Q., Chen J., Ng K.K., Cao W., Zhang Z. & Zheng G.
Imaging the Cytosolic Drug Delivery Mechanism of HDL-Like Nanoparticles
Pharmaceutical Research, 2013.
Liu T.W., Stewart J.M., Macdonald T.D., Chen J., Clarke B., Shi J., Wilson B.C., Neel B. & Zheng G.
Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer
Theranostics, 2013.
Liu T.W., Macdonald T.D., Jin C.S., Gold J.M., Bristow R.G., Wilson B.C. & Zheng G.
Inherently Multimodal Nanoparticle-Driven Tracking and Real-Time Delineation of Orthotopic Prostate Tumors and Micrometastases.
ACS Nano, 2013.
Ng K.K., Lovell J.F., Vedadi A., Hajian T. & Zheng G.
Self-Assembled Porphyrin Nanodiscs with Structure-Dependent Activation for Phototherapy and Photodiagnostic Applications
ACS Nano, 2013.
Huynh E. & Zheng G.
Engineering multifunctional nanoparticles: all-in-one versus one-for-all
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2013.
Jin C.S., Lovell J.F., Chen J. & Zheng G.
Ablation of hypoxic tumors with dose-equivalent photothermal, but not photodynamic, therapy using a nanostructured porphyrin assembly
ACS Nano, 2013.
Liu T.W, Macdonald T.D., Shi J., Wilson B.C. & Zheng G.
Intrinsically Copper-64-Labeled Organic Nanoparticles as Radiotracers
Angewandte Chemie, Int. Ed., 2012.
Tam, N., McVeigh, P., MacDonald, T.D, Farhadi, A., Wilson, B. & Zheng G
Porphyrin–Lipid Stabilized Gold Nanoparticles for Surface Enhanced Raman Scattering Based Imaging
Bioconjugate Chemistry, 2012.
Roxin A. & Zheng, G.
Flexible or fixed: a comparative review of linear and cyclic cancer-targeting peptides
Future Medicinal Chemistry, 2012.       pdf
Roxin, A., Chen, J., Scully, C.C., Rotstein, B.H., Yudin, A.K. & Zheng, G.
Conformational Modulation of in Vitro Activity of Cyclic RGD Peptides via Aziridine Aldehyde-Driven Macrocyclization Chemistry
Bioconjugate Chemistry, 2012.
Lin Q., Chen J., Jin H., Ng K.K., Yang M., Cao W., Ding L., Zhang Z. & Zheng G.
Efficient systemic delivery of siRNA by using high-density lipoprotein-mimicking peptide lipid nanoparticles
Nanomedicine, 2012.       pdf
Huynh, E.; Lovell, J.F.; Helfield, B.L.; Jeon, M.; Kim, C.; Goertz, D.E.; Wilson, B.C. & Zheng, G.
Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties
Journal of the American Chemical Society, 2012.
Lovell, J.F.; Jin, C.S.; Huynh, E.; MacDonald, T.D.; Cao, W. & Zheng G.
Enzymatic Regioselection for the Synthesis and Biodegradation of Porphysome Nanovesicles.
Angewandte Chemie, Int. Ed., 2012.
Jin, H.; Lovell, J.F.; Chen, J.; Lin, Q.; Ding, L.; Ng, K.; Pandey, R.; Manoharan, M.; Zhang, Z. & Zheng G.
Mechanistic insights into LDL nanoparticle-mediated siRNA delivery.
Bioconjugate Chemistry, 2011.
Mawn T.M.; Popov A.V.; Beardsley N.J.; Milkevitch M.; Stefflova K.; Zheng G. & Delikatny EJ.
In vivo Detection of Phospholipase C by Enzyme-Activated Near-infrared Probes.
Bioconjugate Chemistry, 2011.
Lovell, J.F.; Chan, M.W.; Qi, Q.; Chen, J. & Zheng, G.
Porphyrin FRET Acceptors for Apoptosis Induction and Monitoring.
Journal of the American Chemical Society, 2011.
Shi, J.; Liu, T.W.; Chen, J.; Green, D.; Jaffray, D.; Wilson, B.C.;Wang, F. & Zheng, G.
Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer.
Theranostics, 2011.
Jin, C.S. & Zheng, G.
Liposomal Nanostructures for Photosensitizer Delivery.
Lasers in Surgery and Medicine, 2011.
Liu, T.W.; Chen, J.; Burgess, L.; Cao, W.; Shi, J.; Wilson, B.C. & Zheng, G.
Multimodal Bacteriochlorophyll Theranostic Agent.
Theranostics, 2011.
Lovell, J.F.; Roxin, A.; Ng, K.K.; Qi, Q.; McMullen, J.D.; DaCosta, R.S. & Zheng, G.
Porphyrin-Crosslinked-Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection.
Biomacromolecules, 2011.
Liu, T.W.; Akens, M.K; Chen, J.; Wise-Milestone, L.; Wilson, B.C. & Zheng, G.
Imaging of Specific Activation of Photodynamic Molecular Beacons in Breast Cancer Vertebral Metastases.
Bioconjugate Chemistry, 2011.
Yang, M.; Chen, J.;, Cao, W.; Ding, L.; Ng, K.K.; Jin, H.; Zhang, Z. & Zheng, G.
Attenuation of Nontargeted Cell-Kill Using a High-Density Lipoprotein-Mimicking Peptide-Phospholipid Nanoscaffold.
Nanomedicine, 2011.       pdf
Ng, K.K.; Lovell, J.F. & Zheng, G.
Lipoprotein-Inspired Nanoparticles for Cancer Theranostics.
Accounts of Chemical Research, 2011.
Marotta, D.E.; Cao, W.;, Wileyto, E.P.; Li, H.; Corbin, I.; Rickter, E.; Glickson, J.D.; Chance, B.; Zheng, G. & Busch, T.M.
Evaluation of Bacteriochlorophyll-Reconstituted Low-Density Lipoprotein Nanoparticles for photodynamic Therapy Efficacy In Vivo.
Nanomedicine, 2011, 6, 475-487.
Lovell, J.F.; Jin, C.S.; Huynh, E.; Jin, H.; Kim, C.; Rubinstein, J.L.; Chan, W.C.W.; Cao, W.; Wang, L.V. & Zheng, G.
Porphysome Nanovesicles Generated by Porphyrin Bilayers for use as Multimodal Biophotonic Contrast Agents.
Nature Materials, 2011, 20, 324-332.
Jin, H.; Lovell, J.F.; Chen, J.; Ng, K.K.; Ding, L.; Zhang, Z. & Zheng, G.
Cytosolic Delivery of LDL Nanoparticle Cargo Using Photochemical Internalization.
Photochem. Photobiol. Sci., 2011, 10, 810-816.
Yang, M.; Jin, H.; Chen, J.; Ding, L.; Ng., K.K.; Lin, Q.; Lovell, J.F.; Zhang, Z. & Zheng, G.
Efficient Cytosolic Delivery of siRNA Using HDL-Mimicking Nanoparticles.
Small, 2011, 7, 568-573.
Tam, N.C.; Scott, B.M.T.; Voicu, D.; Wilson, B.C. & Zheng, G.
Facile Synthesis of Raman Active Phospholipid Gold Nanoparticles.
Bioconjugate Chemistry, 2010, 21, 2178-2182.
Jin, H.; Lovell, J.F.; Chen, J.; Ng, K.K.; Cao, W.; Ding, L.; Zhang, Z. & Zheng, G.
Investigating the Specific Uptake of EGF-Conjugated Nanoparticles in Lung Cancer Cells Using Fluorescence Imaging.
Cancer Nanotechnology, 2010, 1, 71-78.
Lovell, J.F.; Jin, H.; Ng, K.K. & Zheng, G.
Programmed Nanoparticle Aggregation Using Molecular Beacons.
Angewandte Chemie, Int. Ed., 2010, 49, 7917-7919.
Hill, M.L.; Corbin, I.R.; Levitin, R.B.; Cao, W.; Mainprize, J.G.; Yaffe, M.J. & Zheng, G.
In vitro Assessment of Poly-iodinated Triglyceride Reconstituted Low-Density Lipoprotein: Initial Steps Toward CT Molecular Imaging.
Academic Radiology, 2010, 17, 1359-1365.
Lovell, J.F.; Chen, J.; Huynh, E.; Jarvi, M.T.; Wilson, B.C. & Zheng, G.
Facile Synthesis of Advanced Photodynamic Molecular Beacon Architectures.
Bioconjugate Chem., 2010, 21, 1023-1025
Liu, T.W.B.; Chen, J. & Zheng, G.
Peptide-based Molecular Beacons for Cancer Imaging and Therapy.
Amino Acids, 2010
Lovell, J.F.; Liu, T.W.B.; Chen, J. & Zheng, G.
Activatable Photosensitizers for Imaging and Therapy.
Chemical Reviews, 2010, 110, 2839-2857
Zhang, Z.; Chen, J.; Ding, L.; Jin, H.; Lovell, J.F.; Corbin, I.R.; Cao, W.; Lo, P.; Yang, M.; Tsao, M.; Luo, Q. & Zheng, G.
HDL-Mimicking Peptide-Lipid Nanoparticles with Improved Tumor Targeting.
Small, 2010, 6, 430-437
Zhang, Z.; Cao, W.; Jin, H.; Lovell, J.F.; Yang, M.; Ding, L.; Chen, J.; Corbin, I.; Luo, Q. & Zheng, G.
Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery.
Angewandte Chemie, Int. Ed., 2009, 48, 9171-9175
Cao, W.; Ng, K.K.; Corbin, I.; Zhang, Z.; Ding, L.; Chen, J. & Zheng, G.
Synthesis and Evaluation of a Stable Bacteriochlorophyll-Analog and Its Incorporation into High-Density Lipoprotein Nanoparticles for Tumor Imaging.
Bioconjugate Chem., 2009, 20, 2023-2031
Chen, J.; Liu, T.W.B.; Wilson, B.C. & Zheng, G.
"Zipper" Molecular Beacons: A Generalized Strategy to Optimize the Performance of Activatable Protease Probes.
Bioconjugate Chem., 2009, 20, 1836-1842
Lovell, J.F.; Chen, J.; Jarvi, M.T.; Cao, W.; Allen, A.D.; Liu, Y.; Tidwell, T.T.; Wilson, B.C. & Zheng, G.
FRET Quenching of Photosensitizer Singlet Oxygen Generation
J. Phys. Chem. B, 2009, 113, 3203-3211
Lo, P.; Chen, J; Stefflova, K.; Warren, M.S.; Navab, R.; Bandarchi, B.; Mullins, S.; Tsao, M. Cheng, J.D. & Zheng, G.
Photodynamic Molecular Beacon Triggered by Fibroblast Activation Protein on Cancer-Associated Fibroblasts for Diagnosis and Treatment of Epithelial Cancers
J. Med. Chem., 2009, 52, 358-368
Lovell, J.F.& Zheng, G.
Activatable smart probes for molecular optical imaging and therapy
J. Innov. Opt. Health. Sci., 2008, 1, 45-61       pdf
Chen, J.; Lovell, J.F.; Lo, P.; Stefflova, K.; Niedre, M.; Wilson, B.C. & Zheng, G.
A tumor mRNA-triggered photodynamic molecular beacon based on oligonucleotide hairpin control of singlet oxygen production.
Photochem. Photobiol. Sci., 2008, 7, 775-781
Chen, J.; Jarvi, M.; Lo, P.; Stefflova, K.; Wilson, B.C. & Zheng, G.
Using the singlet oxygen scavenging property of carotenoid in photodynamic molecular beacons to minimize photodamage to non-targeted cells.
Photochem. Photobiol. Sci., 2007, 6, 1311-1317
Zheng, G.; Chen, J.; Stefflova, K.; Jarvi, M.; Li, H. & Wilson, B.C.
Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation
Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 8989-8994       pdf
Chen, J.; Corbin, I.R.; Li, H.; Cao, W.; Glickson, J.D. & Zheng, G.
Ligand conjugated low-density lipoprotein nanoparticles for enhanced optical cancer imaging in vivo
J. Am. Chem. Soc., 2007, 129, 5798-5799
Stefflova, K.; Chen, J. & Zheng, G.
Killer beacons for combined cancer imaging and therapy
Curr. Med. Chem., 2007, 14, 2110-2125
Stefflova, K.; Chen, J. & Zheng, G.
Using molecular beacons for cancer imaging and treatment
Front. Biosci., 2007, 12, 4709-4721
Stefflova, K.; Li, H.; Chen, J. & Zheng, G.
Peptide-based pharmacomodulation of a cancer-targeted optical imaging and photodynamic therapy agent
Bioconjug. Chem., 2007, 18, 379-388
Corbin, I.R. & Zheng, G.
Mimicking nature's nanocarrier: synthetic low-density lipoprotein-like nanoparticles for cancer-drug delivery
Nanomed., 2007, 2, 375-380
Corbin, I. R.; Li, H.; Chen, J.; Lund-Katz, S.; Zhou, R.; Glickson, J. D. & Zheng, G.
Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents
Neoplasia, 2006, 8, 488-498       pdf
Stefflova, K.; Chen, J.; Li, H. & Zheng, G.
Targeted photodynamic therapy agent with a built-in apoptosis sensor for in vivo near-infrared imaging of tumor apoptosis triggered by its photosensitization in situ
Mol. Imaging, 2006, 5, 520-532
Stefflova, K.; Chen, J.; Marotta, D.; Li, H. & Zheng, G.
Photodynamic therapy agent with a built-in apoptosis sensor for evaluating its own therapeutic outcome in situ
J. Med. Chem., 2006, 49, 3850-3856
Li, H.; Marotta, D.E.; Kim, S.; Busch, T. M.; Wileyto, E.P. & Zheng, G.
High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles
J. Biomed. Opt., 2005, 10, 41203
Zheng, G.; Chen, J.; Li, H. & Glickson, J. D.
Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents
Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 17757-17762
Wu, S.P.; Lee, I.; Ghoroghchian, P.P.; Frail, P.R.; Zheng, G.; Glickson, J.D. & Therien, M.J.
Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores
Bioconjug. Chem., 2005, 16, 542-550
Zhang, Z.; Li, H.; Liu, Q.; Zhou, L.; Zhang, M.; Luo, Q.; Glickson, J.; Chance, B. & Zheng, G.
Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers
Biosens. Bioelectron., 2004, 20, 643-650
Li, H.; Zhang, Z.; Blessington, D.; Nelson, D. S.; Zhou, R.; Lund-Katz, S.; Chance, B.; Glickson, J. D. & Zheng, G.
Carbocyanine labeled LDL for optical imaging of tumors
Acad. Radiol., 2004, 11, 669-677
Zhang, Z.; Blessington, D.; Li, H.; Busch, T.M.; Glickson, J.; Luo, Q.; Chance, B. & Zheng, G.
Redox ratio of mitochondria as an indicator for the response of photodynamic therapy
J. Biomed. Opt., 2004, 9, 772-778
Chen, J.; Stefflova, K.; Niedre, M. J.; Wilson, B.C.; Chance, B.; Glickson, J.D. & Zheng, G.
Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation
J. Am. Chem. Soc., 2004, 126, 11450-11451