Structural Proteomics in Toronto

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  1. Yakunin AF, Proudfoot M, Kuznetsova E, Savchenko A, Brown G, Arrowsmith CH, Edwards AM.
    The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities.
    J Biol Chem. 2004 Aug 27;279(35):36819-27. Epub 2004 Jun 20.
    PubMed ID: 15210699
  2. Blanco FJ, Yee A, Campos-Olivas R, Ortiz AR, Devos D, Valencia A, Arrowsmith CH, Rico M.
    Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold.
    Protein Sci. 2004 Jun;13(6):1458-65.
    PubMed ID: 15152082
  3. Saridakis V, Yakunin A, Xu X, Anandakumar P, Pennycooke M, Gu J, Cheung F, Lew JM, Sanishvili R, Joachimiak A, Arrowsmith CH, Christendat D, Edwards AM.
    The structural basis for methylmalonic aciduria. The crystal structure of archaeal ATP:cobalamin adenosyltransferase.
    J Biol Chem. 2004 May 28;279(22):23646-53. Epub 2004 Mar 25.
    PubMed ID: 15044458
  4. Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W.
    Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.
    Protein Sci. 2004 Apr;13(4):1148-54.
    PubMed ID: 15044740
  5. Gutierrez P, Osborne MJ, Siddiqui N, Trempe JF, Arrowsmith C, Gehring K.
    Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation.
    Protein Sci. 2004 Mar;13(3):659-67.
    PubMed ID: 14978306
  6. Yakunin AF, Yee AA, Savchenko A, Edwards AM, Arrowsmith CH.
    Structural proteomics: a tool for genome annotation.
    Curr Opin Chem Biol. 2004 Feb;8(1):42-8. Review.
    PubMed ID: 15036155
  7. Kim Y, Yakunin AF, Kuznetsova E, Xu X, Pennycooke M, Gu J, Cheung F, Proudfoot M, Arrowsmith CH, Joachimiak A, Edwards AM, Christendat D.
    Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum.
    J Biol Chem. 2004 Jan 2;279(1):517-26. Epub 2003 Oct 10.
    PubMed ID: 14555659
  8. Monleon D, Yee A, Liu CS, Arrowsmith C, Celda B.
    Solution structure of hypothetical protein TA1414 from Thermoplasma acidophilum.
    J Biomol NMR. 2004 Jan;28(1):81-4. No abstract available.
    PubMed ID: 14739641
  9. Savchenko A, Skarina T, Evdokimova E, Watson JD, Laskowski R, Arrowsmith CH, Edwards AM, Joachimiak A, Zhang RG.
    X-ray crystal structure of CutA from Thermotoga maritima at 1.4 A resolution.
    Proteins. 2004 Jan 1;54(1):162-5. No abstract available.
    PubMed ID: 14705033
  10. Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA.
    Solution structure of the yeast ubiquitin-like modifier protein Hub1.
    J Struct Funct Genomics. 2003;4(1):25-30. No abstract available.
    PubMed ID: 12943364
  11. Wu B, Yee A, Pineda-Lucena A, Semesi A, Ramelot TA, Cort JR, Jung JW, Edwards A, Lee W, Kennedy M, Arrowsmith CH.
    Solution structure of ribosomal protein S28E from Methanobacterium thermoautotrophicum.
    Protein Sci. 2003 Dec;12(12):2831-7.
    PubMed ID: 14627743
  12. Xia Y, Yee A, Arrowsmith CH, Gao X.
    1H(C) and 1H(N) total NOE correlations in a single 3D NMR experiment. 15N and 13C time-sharing in t1 and t2 dimensions for simultaneous data acquisition.
    J Biomol NMR. 2003 Nov;27(3):193-203.
    PubMed ID: 12975580
  13. Maxwell KL, Bona D, Liu C, Arrowsmith CH, Edwards AM.
    Refolding out of guanidine hydrochloride is an effective approach for high-throughput structural studies of small proteins.
    Protein Sci. 2003 Sep;12(9):2073-80.
    PubMed ID: 12931005
  14. Tao X, Khayat R, Christendat D, Savchenko A, Xu X, Goldsmith-Fischman S, Honig B, Edwards A, Arrowsmith CH, Tong L.
    Crystal structures of MTH1187 and its yeast ortholog YBL001c.
    Proteins. 2003 Aug 15;52(3):478-80. No abstract available.
    PubMed ID: 12866058
  15. Sanishvili R, Yakunin AF, Laskowski RA, Skarina T, Evdokimova E, Doherty-Kirby A, Lajoie GA, Thornton JM, Arrowsmith CH, Savchenko A, Joachimiak A, Edwards AM.
    Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli.
    J Biol Chem. 2003 Jul 11;278(28):26039-45. Epub 2003 May 05.
    PubMed ID: 12732651
  16. Kimber MS, Vallee F, Houston S, Necakov A, Skarina T, Evdokimova E, Beasley S, Christendat D, Savchenko A, Arrowsmith CH, Vedadi M, Gerstein M, Edwards AM.
    Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens.
    Proteins. 2003 Jun 1;51(4):562-8.
    PubMed ID: 12784215
  17. Pineda-Lucena A, Liao JC, Cort JR, Yee A, Kennedy MA, Edwards AM, Arrowsmith CH.
    A novel member of the split betaalphabeta fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae.
    Protein Sci. 2003 May;12(5):1136-40.
    PubMed ID: 12717036
  18. Gerstein M, Edwards A, Arrowsmith CH, Montelione GT.
    Structural genomics: current progress.
    Science. 2003 Mar 14;299(5613):1663. No abstract available.
    PubMed ID: 12637721
  19. Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L.
    Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.
    J Biol Chem. 2003 Mar 7;278(10):8804-8. Epub 2002 Dec 21.
    PubMed ID: 12496312
  20. Yee A, Pardee K, Christendat D, Savchenko A, Edwards AM, Arrowsmith CH.
    Structural proteomics: toward high-throughput structural biology as a tool in functional genomics.
    Acc Chem Res. 2003 Mar;36(3):183-9.
    PubMed ID: 12641475
  21. Zarembinski TI, Kim Y, Peterson K, Christendat D, Dharamsi A, Arrowsmith CH, Edwards AM, Joachimiak A.
    Deep trefoil knot implicated in RNA binding found in an archaebacterial protein.
    Proteins. 2003 Feb 1;50(2):177-83. No abstract available.
    PubMed ID: 12486711
  22. Zhang R, Andersson CE, Savchenko A, Skarina T, Evdokimova E, Beasley S, Arrowsmith CH, Edwards AM, Joachimiak A, Mowbray SL.
    Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle.
    Structure (Camb). 2003 Jan;11(1):31-42.
    PubMed ID: 12517338
  23. Kennedy MA, Montelione GT, Arrowsmith CH, Markley JL.
    Role for NMR in structural genomics.
    J Struct Funct Genomics. 2002;2(3):155-69.
    PubMed ID: 12836706
  24. Ramelot TA, Cort JR, Yee AA, Semesi A, Edwards AM, Arrowsmith CH, Kennedy MA.
    NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins.
    Proteins. 2002 Nov 1;49(2):289-93. No abstract available.
    PubMed ID: 12211008
  25. Batra R, Christendat D, Edwards A, Arrowsmith C, Tong L.
    Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase.
    Proteins. 2002 Nov 1;49(2):285-8. No abstract available.
    PubMed ID: 12211007
  26. Ramelot TA, Cort JR, Yee AA, Liu F, Goshe MB, Edwards AM, Smith RD, Arrowsmith CH, Dever TE, Kennedy MA.
    Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha.
    J Mol Biol. 2002 Oct 4;322(5):943-54.
    PubMed ID: 12367520
  27. Xia Y, Arrowsmith CH, Szyperski T.
    Novel projected 4D triple resonance experiments for polypeptide backbone chemical shift assignment.
    J Biomol NMR. 2002 Sep;24(1):41-50.
    PubMed ID: 12449417
  28. Kim Y, Skarina T, Beasley S, Laskowski R, Arrowsmith C, Joachimiak A, Edwards A, Savchenko A.
    Crystal structure of Escherichia coli EC1530, a glyoxylate induced protein YgbM.
    Proteins. 2002 Aug 1;48(2):427-30. No abstract available.
    PubMed ID: 12112708
  29. Saridakis V, Christendat D, Thygesen A, Arrowsmith CH, Edwards AM, Pai EF.
    Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold.
    Proteins. 2002 Jul 1;48(1):141-3. No abstract available.
    PubMed ID: 12012346
  30. Christendat D, Saridakis V, Kim Y, Kumar PA, Xu X, Semesi A, Joachimiak A, Arrowsmith CH, Edwards AM.
    The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.
    Protein Sci. 2002 Jun;11(6):1409-14.
    PubMed ID: 12021439
  31. Pineda-Lucena A, Liao J, Wu B, Yee A, Cort JR, Kennedy MA, Edwards AM, Arrowsmith CH.
    NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli.
    Proteins. 2002 Jun 1;47(4):572-4. No abstract available.
    PubMed ID: 12001238
  32. Zhang RG, Kim Y, Skarina T, Beasley S, Laskowski R, Arrowsmith C, Edwards A, Joachimiak A, Savchenko A.
    Crystal structure of Thermotoga maritima 0065, a member of the IclR transcriptional factor family.
    J Biol Chem. 2002 May 24;277(21):19183-90. Epub 2002 Mar 04.
    PubMed ID: 11877432
  33. Maxwell KL, Yee AA, Arrowsmith CH, Gold M, Davidson AR.
    The solution structure of the bacteriophage lambda head-tail joining protein, gpFII.
    J Mol Biol. 2002 May 17;318(5):1395-404.
    PubMed ID: 12083526
  34. Gutierrez P, Coillet-Matillon S, Arrowsmith C, Gehring K.
    Zinc is required for structural stability of the C-terminus of archaeal translation initiation factor aIF2beta.
    FEBS Lett. 2002 Apr 24;517(1-3):155-8.
    PubMed ID: 12062427
  35. Bhattacharyya S, Habibi-Nazhad B, Amegbey G, Slupsky CM, Yee A, Arrowsmith C, Wishart DS.
    Identification of a novel archaebacterial thioredoxin: determination of function through structure.
    Biochemistry. 2002 Apr 16;41(15):4760-70.
    PubMed ID: 11939770
  36. Pineda-Lucena A, Yi GS, Chang X, Cort JR, Kennedy MA, Edwards AM, Arrowsmith CH.
    Solution structure of the hypothetical protein MTH0637 from Methanobacterium thermoautotrophicum.
    J Biomol NMR. 2002 Mar;22(3):291-4. No abstract available.
    PubMed ID: 11991357
  37. Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH.
    An NMR approach to structural proteomics.
    Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1825-30.
    PubMed ID: 11854485
  38. Korolev S, Ikeguchi Y, Skarina T, Beasley S, Arrowsmith C, Edwards A, Joachimiak A, Pegg AE, Savchenko A.
    The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
    Nat Struct Biol. 2002 Jan;9(1):27-31.
    PubMed ID: 11731804
  39. Das K, Xiao R, Wahlberg E, Hsu F, Arrowsmith CH, Montelione GT, Arnold E.
    X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold.
    Proteins. 2001 Dec 1;45(4):486-8. No abstract available.
    PubMed ID: 11746696
  40. Zhang RG, Skarina T, Katz JE, Beasley S, Khachatryan A, Vyas S, Arrowsmith CH, Clarke S, Edwards A, Joachimiak A, Savchenko A.
    Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.
    Structure (Camb). 2001 Nov;9(11):1095-106.
    PubMed ID: 11709173
  41. Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP.
    NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum.
    J Biomol NMR. 2001 Sep;21(1):63-6. No abstract available.
    PubMed ID: 11693569
  42. Bertone P, Kluger Y, Lan N, Zheng D, Christendat D, Yee A, Edwards AM, Arrowsmith CH, Montelione GT, Gerstein M.
    SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics.
    Nucleic Acids Res. 2001 Jul 1;29(13):2884-98.
    PubMed ID: 11433035
  43. Maxwell KL, Yee AA, Booth V, Arrowsmith CH, Gold M, Davidson AR.
    The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold.
    J Mol Biol. 2001 Apr 20;308(1):9-14.
    PubMed ID: 11302702
  44. Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA.
    NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum.
    J Struct Funct Genomics. 2000;1(1):15-25.
    PubMed ID: 12836677
  45. Christendat D, Yee A, Dharamsi A, Kluger Y, Gerstein M, Arrowsmith CH, Edwards AM.
    Structural proteomics: prospects for high throughput sample preparation.
    Prog Biophys Mol Biol. 2000;73(5):339-45. Review. No abstract available.
    PubMed ID: 11063779
  46. Edwards AM, Arrowsmith CH, Christendat D, Dharamsi A, Friesen JD, Greenblatt JF, Vedadi M.
    Protein production: feeding the crystallographers and NMR spectroscopists.
    Nat Struct Biol. 2000 Nov;7 Suppl:970-2. Review.
    PubMed ID: 11104003
  47. Christendat D, Yee A, Dharamsi A, Kluger Y, Savchenko A, Cort JR, Booth V, Mackereth CD, Saridakis V, Ekiel I, Kozlov G, Maxwell KL, Wu N, McIntosh LP, Gehring K, Kennedy MA, Davidson AR, Pai EF, Gerstein M, Edwards AM, Arrowsmith CH.
    Structural proteomics of an archaeon.
    Nat Struct Biol. 2000 Oct;7(10):903-9.
    PubMed ID: 11017201
  48. Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA.
    Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum.
    J Mol Biol. 2000 Sep 8;302(1):189-203.
    PubMed ID: 10964569
  49. Christendat D, Saridakis V, Dharamsi A, Bochkarev A, Pai EF, Arrowsmith CH, Edwards AM.
    Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
    J Biol Chem. 2000 Aug 11;275(32):24608-12.
    PubMed ID: 10827167
  50. Mackereth CD, Arrowsmith CH, Edwards AM, McIntosh LP.
    Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum.
    Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6316-21.
    PubMed ID: 10841539
  51. Yee A, Booth V, Dharamsi A, Engel A, Edwards AM, Arrowsmith CH.
    Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum.
    Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6311-5.
    PubMed ID: 10841538

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