Structural Proteomics in Toronto

Alexei Savchenko

My research has been directed towards understanding the structural determinants of protein function. I am particularly interested in proteins participating in bacterial adaptation to the changes in chemical environment. Currently we are focusing on bacterial one-component systems, which regulate the transcription in response to the presence of different small molecules – effectors. Hundreds of such proteins are identified by the presence of known DNA binding motif (usually Helix-Turn-Helix) in each bacterial genomes, while the effector molecules and molecular mechanisms behind their recognition by one-component systems remain unknown.

Alexei is the group leader of the IclR group and the Structural Proteomics group

Biography

e-mail: alexei.savchenko@utoronto.ca
phone: 416-946-0082

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