Recent Publications

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2023 Publications

Yammine SZ, Burns I, Gosio J, Peluso A, Merritt DM, Innes B, Coles BLK, Yan WR, Bader GD, Morshead CM, van der Kooy D. Fate specification of GFAP-negative primitive neural stem cells and their progeny at clonal resolution. Stem Cells and Development. 2023 Oct; 32(19-20):606-621. DOI: 10.1089/scd.2023.0038. (yammine...2023)

Merritt DM, Udachina A, Freidel N, Almeida SMT, Lau YMA, van der Kooy D. A novel memory type in C. elegans exhibits post-training consolidation. BioRxiv. 2023 Feb 22. DOI: 10.1101/2023.02.22.529281. (merritt...2023)

Vargas-Perez H, Grieder TE, van der Kooy D. Neural plasticity in the ventral tegmental area, aversive motivation during drug withdrawal and hallucinogenic therapy. Journal of Psychoactive Drugs. 2023 Jan-Mar; 55(1):62-72. DOI: 10.1080/02791072.2022.2033889. (vargas-perez...2023)

2022 Publications

Merritt DM, MacKay-Clackett I, Almeida SMT, Trans C, Ansar S, van der Kooy D. Arrestin-mediated desensitization enables intraneuronal olfactory discrimination in Caenorhabditis elegans. Proceedings of the National Academy of Science of United States of America. 2022 Aug 2; 119(31):e2116957119. DOI: 10.1073/pnas.2216957119. (merritt...2022)

Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependant D1R-mediated motivational state to a nicotine-dependant-like D2R-mediated motivational state. European Journal of Neuroscience. 2021 Dec 28. DOI: 10.1111/ejn.15579. (grieder...2022)

2021 Publications

Grise KN, Coles BLK, Bautista NX, van der Kooy D. Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2. Stem Cell Research & Therapy. 2021 Oct 30; 12(1):560. DOI:10.1186/s13287-021-02630-0.(grise...2021)

Coles BLK, Labib M, Poudineh M, Innes BT, Belair-Hickey J, Gomis S, Wang Z, Bader GD, Sargent EH, Kelley SO, van der Kooy D. A microfluidic platform enables comprehensive gene expression profiling of mouse retinal stem cells. Lab on a Chip. 2021 Nov 9;21:4464-4476. DOI:10.1039/d1lc00790d. (coles...2021)

Merritt D, MacKay-Clackett I, Almeida SMT, Tran C, Ansar S, van der Kooy D. Arrestin-mediated desensitization enables olfactory discrimination in C. elegans. bioRxiv. https://doi.org/10.1101/2021.05.02.439367. (merritt...2021)

Baakhdah TW, Coles BL, van der Kooy D. A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation. iScience. 2021 Jun 25;24:102574. (baakhdah...2021)

Baker AEG, Cui H, Ballios BG, Ing S, Yan P, Wolfer J, Wright T, Dang M, Gan NY, Cooke MJ, Ortin-Martinez A, Wallace VA, van der Kooy D, Devenyi R, Shoichet MS. Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute. Biomaterials. 2021 Apr;271:120750. (baker...2021)

Adams KV, Mahmud N, Green-Holland M, Vondervalde I, Umebayashi D, Sachewski N, Coles BL, van der Kooy D, Morshead CM. Constraint-induced movement therapy promotes motor recovery after neonatal stroke in the absence of neural precursor activation. European Journal of Neuroscience. 2021 Feb;53(4):1334:1249. (adams...2021)

Griese KN, Bautista NX, Jacques-Smith K, Coles BLK, van der Kooy D. Glucocorticoid agonists enhance retinal stem cell self-renewal and proliferation. Stem Cell Research & Therapy. 2021 Jan 25;12(1):83. (griese...2021)

2020 Publications

Maal-Bared G, Yee M, Harding EK, Ghebreselassie M, Bergamini M, Choy R, Kim E, Di Vito S, Patel M, Amirzadeh M, Grieder TE, Nagy JI, Bonin RP, van der Kooy D. Connexin-36-expressing Gap junctions in VTA GABA neurons sustain opiate dependence. bioRxiv. 2020 Dec 21. https://doi.org/10.1101/2020.12.18.423554. (maal-bared...2020)

DeVeale B, van der Kooy D. Parental Bias Has Benefits. Neuron. 2020 Sep 23;107(6):994-996. (DeVeale...2020)

Mitrousis N, Hacibekiroglu S, Ho MT, Sauvé Y, Nagy A, van der Kooy D, Shoichet MS. Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration. Biomaterials. 2020 Oct;257:120233. (mitrousis...2020)

Ahuja CS, Mothe A, Khazaei M, Badhiwala JH, Gilbert EA, van der Kooy D, Morshead CM, Tator C, Fehlings MG. The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury. Stem Cells Transl Med. 2020 Jul 21. (ahuja...2020 )

Yee M, Maal-Bared G, Ting-A-Kee R, Chwalek M, Mackay-Clackett I, Bergamini M, Griede TE, van der Kooy D. Segregation of caffeine reward and aversion in the rat nucleus accumbens shell versus core. Eur J Neurosci. 2020 Aug;52(3):3074-3086. (yee...2020)

2019 Publications

Ballios BG, Khalili S, van der Kooy D. Induction of Rod and Cone Photoreceptor-Specific Progenitors from Stem Cells. Adv Exp Med Biol. 2019;1185:551-555. (ballios...2019)

Grieder TE, Besson M, Maal-Bared G, Pons S, Maskos U, van der Kooy D. β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25968-25973. (grieder...2019)

Sachewsky N, Xu W, Fuehrmann T, van der Kooy D, Morshead CM. Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain.Sci Rep. 2019 Nov 27;9(1):17730. (sachewsky...2019)

Wolfe GS, Tong VW, Povse E, Merritt DM, Stegeman GW, Flibotte S, van der Kooy D. A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans. eNeuro. 2019 Aug 13;6(4). pii: ENEURO.0244-18.2019. (wolfe...2019)

Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW. Cell competition during reprogramming gives rise to dominant clones. Science. 2019 Apr 26;364(6438). pii: eaan0925 (shakiba...2019)

Baakhdah T, van der Kooy D. Expansion of retinal stem cells and their progeny using cell microcarriers in a bioreactor. Biotechnol Prog. 2019 Mar 6:e2800 (baakhdah...2019)

Merritt DM, Melkis JG, Kwok B, Tran C, van der Kooy D. Analysis of Mutants Suggests Kamin Blocking in C. elegans is Due to Interference with Memory Recall Rather than Storage. Sci Rep. 2019 Feb 20;9(1):2371 (merritt...2019)

Brokhman I, Xu J, Coles BLK, Razavi R, Engert S, Lickert H, Babona-Pilipos R, Morshead CM, Sibley E, Chen C, van der Kooy D. Dual embryonic origin of the mammalian enteric nervous system. Dev Biol. 2019 Jan 15;445(2):256-270 (brokhman...2019)

2018 Publications

Rumajogee P, Altamentova S, Li L, Li J, Wang J, Kuurstra A, Khazaei M, Beldick S, menon RS, van der Kooy D, fehlings MG. Exogenous Neural Precursor Cell Transplantation Results in Structural and Functional Recovery in a Hypoxic-Ischemic Hemiplegic Mouse Model. eNeuro. 2018 Dec 4;5(5). pii: ENEURO.0369-18.2018 (rumajogee...2018...)

Gomis S, Labib M, Coles BLK, van der Kooy D, Sargent EH, Kelley SO. Single-Cell Tumbling Enables High-Resolution Size Profiling of Retinal Stem Cells. ACS Appl Mater Interfaces. 10 (41) (2018) 34811–34816 (gomes...2018...)

Khalili S, Ballios BG, Belair-Hickey J, Donaldson L, Liu J, Coles BLK, Grisé KN, Baakdhah T, Bader GD, Wallace VA, Bernier G, Shoichet MS, van der Kooy D. Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells. Stem Cell Res. 33 (2018) 215-227 (khalili...2018...)

Li N, van der Kooy D. Mutations in the guanylate cyclase gcy-28 neuronally dissociate naïve attraction and memory retrieval. Eur J Neurosci. 48(11) (2018) 3367-3378 (li...2018...)

2017 Publications

Coles-Takabe B, van der Kooy D. P-Cadherin is necessary for retinal stem cell behavior in vitro, but not in vivo. Stem Cell Research 21 (2017) 141-147 (coles...2017...)

Grieder TE, George O, Yee M, Bergamini MA, Chwalek M, Maal-Bared G, Vargas-Perez H, van der Kooy D. Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism. European Journal of Neuroscience. 46(1) (2017) 1673-1681 (grieder...2017...)

Reeve R, Yammine S, Morshead C, van der Kooy D. Quiescent Oct4+ neural stem cells (NSCs) repopulate ablated GFAP+ NSCs in the adult mouse brain. Stem Cells. (2017) [epub ahead of print] (reeve...2017...)

Vargas-Perez H, Grieder TE, Ting-A-Kee R, Maal-Bared G, Chwalek M, van der Kooy D. A single administration of the hallucinogen, 4-acetoxy-dimethyltryptamine, prevents the shift to a drug-dependent state and the expression of withdrawal aversions in rodents. European Journal of Neuroscience. European Journal of Neuroscience. 45(11) (2017)1410-1417 (vargas-perez...2017...)

2016 Publications

Führmann T, Tam RY, Ballarin B, Coles B, Elliott Donaghue I, van der Kooy D, Nagy A, Tator CH, Morshead CM, Shoichet MS. Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord injury model. Biomaterials. 83 (2016) 23-36 (fuhrmann...2016...)

Huroy S, Kanawaty A, Magomedova L, Cummins CL, George SR, van der Kooy D, Henderson JT. EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function. Behavioural Brain Research. 300 (2016) 85-96 (huroy...2016...)

Mitrousis N, Tam RY, Baker AEG, van der Kooy D, Shoichet MS. Hyaluronic acid-based hydrogels enable rod photoreceptor survival and maturation in vitro through activation of the mTOR pathway Advanced Functional Materials. 26 (2016) 1975-85 (mitrousis...2016...)

Reeve RL, Yammine SZ, De Veale B, van der Kooy D. Targeted activation of primitive neural stem cells in the mouse brain. European Jouranl of Neuroscience. 43(11) (2016) 1474-85 (reeve...2016...)

Umebayashi D, Coles B, van der Kooy D. Enrichment of oligodendrocyte progenitors from differentiated neural precursors by clonal sphere preparations. Stem Cells and Development. 25(9) (2016) 712-28 (umebayahi...2016...)

2015 Publications

Babak T, DeVeale B, Tsang EK, Zhou Y, Li X, Smith KS, Kukurba KR, Zhang R, Li JB, van der Kooy D, Montgomery SB, Fraser HB. Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse. Nature Genetics. 47(5) (2015) 544-549 (babak...2015...)

Ballios BG, Cooke MJ, Donaldson L, Coles BL, Morshead CM, van der Kooy D, Shoichet MS. A Hyaluronan-Based Injectable hydrogel improves the survival and integration of stem cell progeny following transplantation. Stem Cell Reports. 4(6) (2015) 1031–1045 (ballios...2015...)

Razavi, R., Abdullah, S., Arntfield, M., Shateri, H., Smukler, S., van der Kooy D. Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more B-cell production. Diabetes. 64 (4) (2015)1211-1323 (razavi...2015...)

Ting-A-Kee R, Heinmiller A, van der Kooy D. A proposed resolution to the paradox of drug reward: Dopamine's evolution from an aversive signal to a facilitator of drug reward via negative reinforcement. Neuroscience and Biobehavioural Reviews. 56 (2015) 50-61 (ting...2015...)

2014 Publications

Balenci, L., van der Kooy, D. Notch signaling induces retinal stem-like properties in perinatal neural retina progenitors and promotes symmetrical divisions in adult retinal stem cells. Stem Cells and Development Stem Cells and Devlopment. 23(3) (2014) 230-44 (balenci...2013...)

Bufalino, M.R, van der Kooy, D. The aggregation and inheritance of damaged proteins determines cell fate during mitosis. Cell Cycle. 13(7) (2014) 1201-7. (bufalino...2014...)

Deveale, B, Bausch-Fluck, D, Seaberg, R, Runciman, S, Akbarian, V, Karpowicz, P, Yoon, C, Song, H, Leeder, R, Zandstra, PW, Wollscheid, B, van der Kooy, D. Surfaceome profiling reveals regulators of neural stem cell function. Stem Cells. 32(1) (2014) 258-68 (deveale...2013...)

Greider, T., Vargas-Perez, H., Herman, M, Contet, C., Tan, L., Freiling, J., Clarke, L., Crawford, E., Koebel, P., Roberto, M., Kieffer, BL., Sawchenko, PE., Koob, GF, van der Kooy, D., George, O. Identification of CRF neurons in the ventral tegmentatal area that control the aversive effects of nicotine withdrawal. Nature Neuroscience. 17(12) (2014) 1751-8 (grieder...2014...)

Michael1, IP.,Westenskow, PD., Hacibekiroglu, S., Greenwald, AC., Ballios, BG., Kurihara, T., Li, Z., Warren, C., Zhang, P., Aguilar, E., Donaldson, L., Marchetti, V., Baba, T., Hussein, SM., Sung, H., Iruela-Arispe, ML., Rini, JM van der Kooy, D., Friedlander, M., Nagy, A. Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Molecular Medicine. 6(5) (2014) 604–623. (michael...2014...)

Sachewsky, N., Leeder, R., Xu, W., Rose, K.L., Yu, F., van der Kooy, D., Morshead, C.M. Primitive neural stem cells in the adult mammalian brain give rise to the GFAP expressing neural stem cells. Stem Cell Reports. 2 (6) (2014) 810-24. (sachewsky...2014...)

Teichert, A.M., Pereira, S., Coles, B., Chaddah, R., Runciman, S., Brokhman, I., van der Kooy, D. The neural stem cell lineage reveals novel relationships among spermatogonial germ stem cells and other pluripotent stem cells. Stem Cells and Development. 23(7) (2014) 767-78. (teichert...2014...)

Vargas-Perez, H., Bahi, A., Bufalino, M.R., Ting-A-Kee, R., Fahmy, A., Maal-Bared, G., Clarke, L., Lam, J., Blanchard, J., Larsen, B., Steffensen, S., Dreyer, J.L., van der Kooy, D. BDNF signaling in the VTA links the drug dependent state to drug withdrawal aversions. Journal of Neuroscience. 34(23) (2014) 7899-909. (vargas...2014...)

2013 Publications

Arntfield, M., van der Kooy, D. The adult mammalian pancreas contains separate stem cells of pancreatic and neural crest developmental origins. Stem Cells and Development. 22(15) (2013) 2145-57 (arntfield...2013...)

Ballios BG, Marigo V, van der Kooy D. Directed differentiation of retinal stem cells into photoreceptors and retinal pigment epithelium. In Kaur N, Vemuri M (Eds.), Neural Stem Cell Assays. Wiley-Blackwell, New Jersey, 2013.

Balenci L, Wonders C, L Kcoles-Takabe B, Clarke L, van der Kooy D. Bmps and Sfrp2 maintain the quiescence of adult mammalian retinal stem cells. Stem Cells. 31(10) (2013) 2218-30 (balencil...2013...)

Bufalino, M. R. DeVeale, B., van der Kooy, D. Damaged protein segregation differs between asymmetrically dividing stem cell populations. Journal of Cell Biology 4(201) 201(4) (2013). 523-30 (bufalino...2013...)

Deveale B, Brokhman I, Mohseni P, Babak T, Yoon C, Lin A, Onishi K, Tomilin A, Pevny L, Zandstra PW, Nagy A, van der Kooy D. Oct4 is required ∼e7.5 for proliferation in the primitive streak. PLoS Genetics. 9(11) (2013) e1003957 (devealb...2013...)

Holowacz, T., Alexson, T., Coles, B., Doble, B.W., Kelly., K., Woodgett, J.R., van der Kooy, D. The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin. Biology Open. 2(8) (2013) 812-21 (holowacz...2013...)

Pereira, S., van der Kooy, D. Entwined Engrams: The evolution of associative and non-associative learning. Worm. 32(26) (2013) 9035-44 PMID: 22745502 (pereira...2013...)

Riad-Allen L, van der Kooy D. Social defeat stress switches the neural system mediating benzodiazepine conditioned motivation. Behavioural Neuroscience. 127(4) (2013) 515-23 (riad...2013)

Salewski, R.P., Buttigieg, J., Mitchell, R.A., van der Kooy, D., Nagy, A., Fehlings, M.G. The generation of definitive neural stem cells from piggybac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway. Stem Cells and Development. 22(3) (2013) 383-396. (salewski...2013...)

Sellings L, Pereira S, Qian C, Dixon-McDougall T, Nowak C, Zhao B, Tyndale RF, van der Kooy D. Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15. European Journal of Neuroscience. 37(5) (2013) 743-56 (sellings...2013...)

Ting-A-Kee R, Vargas-Perez H, Mabey JK, Shin SI, Steffensen SC, van der Kooy D. Ventral tegmental area GABA neurons and opiate motivation. Psychopharmacology (Berl). 227(4) (2013) 697-709 (ting...2013...)

Ting-A-Kee, R., Mercuriano, L.E., Vargas-Perez, H., George, S.R., van der Kooy, D. Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent Manner. Behavioural Brain Research. 26 (247C) (2013)174-177. (ting...mercuriano...2013...)

Ting-A-Kee R, Vargas-Perez H, Bufalino MR, Bahi A, Dreyer JL, Tyndale RF, van der Kooy D. Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation. Euoropean Journal of Neuroscience. 37(6) (2013) 996-1003.